Malignite Kaynaklı Plevra Sıvılarında CEA, CA 15-3, CA 19-9, CA 125, CA 72-4 ve AFP Düzeyinin Tanısal Değeri
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Dosyalar
Tarih
2001
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Bu çalışma; 1998-1999 yılları arasında Selçuk Üniversitesi Tıp Fakültesi Göğüs Hastalıkları ve Tüberküloz Anabilim Dalı'nda yatırılarak tetkik edilen plevral efüzyonlu 81 olguda yapıldı. Olgularda plevral sıvı ve serum CEA, CA 15-3, CA 19-9, CA 125, CA 72-4, AFP düzeyleri araştırıldı. Hastalar malign ve benign hastalık grubu olmak üzere ikiye ayrıldı. Olgulardaki plevral efüzyonun 41'i çoğunluğu akciğer kanseri olmak üzere malignite kaynaklı, 40'ı ise benign nedenlere bağlı idi. Malign ve benign hastalık grubunda ortalama plevral sıvı CEA düzeyi sırasıyla 28.86 37.34 ng/mL, 1.42 0.93 ng/mL (p 0.001), CA 15-3 düzeyi 108.55 150.43 U/mL, 15.91 22.20 U/mL (p 0.001), CA 19-9 düzeyi 45.39 137.26 U/mL, 14.03 43.96 U/mL (p 0.05), CA 125 düzeyi 703.23 491.51 U/mL, 565.30 381.99 U/mL (p 0.05), AFP dü-. zeyi 1.58 1.39 ng/mL, 2.00 3.04 ng/mL (p 0.05), CA 72-4 düzeyi 11.14 23.83 U/mL, 0.67 1.51 U/mL (p 0.001) olarak bulundu. Sonuçta, malign ve benign plevral sıvıların ayırıcı tanısında, CEA (sensitivite %56.0, spesifite %95.0), CA 15-3 (sensitivite %53.6, spesifite %80.0), CA 72-4 (sensitivite %26, spesifite %95), CA 125 (sensitivite %65.8, spesifite %42.5).düzeyleri istatistiksel olarak anlamlı bulundu.
This study was performed between 1998-1999 in Selçuk University Medical Faculty Department of Chest Diseases, 81 patients with pleural effusions were hospitalized and their CEA, CA 15-3, CA 19-9, CA 125, CA 72-4, AFP levels of pleural fluid and serum are investigated. The patients were seperated in two groups according to their etiologies malignant pleural effusions and benign pleural effusions. The pleural effusions with 41 cases were due to malignancy and most of them have lung cancer. In the other 40 cases the cause was nonmalignant origin. In pleural fluids, CEA level was 28.86 ± 37.34 ng/mL in malignant group and 1.42 ± 0.93 ng/mL in benign group (p< 0.001). CA 15-3 was 108.55 ± 150.43 U/mL, 15.91 ± 22.20 U/mL (p<0.001). CA 19-9 was 45.39 ± 137.26 U/mL, 14.03 ± 43.96 U/mL (p>0.05). CA 125 was 703.23 ± 491.51 U/mL, 565.30 ± 381.99 U/mL (p<0.05). AFP was 1.58 ± 1.39 ng/mL, 2.00 ± 3.04 ng/mL (p>0.05). CA 72-4 was 11.14 ± 23.83 U/mL, 0.67 ± 1.51 U/mL (p<0.001). In conclusion, CEA (sensitivity 56.0%, specificity 95.0%), CA 15-3 (sensitivity 53.6%, specificity 80.0%), CA 72-4 (sen- sitivity 26%, specificity 95%), CA 125 (sensitivity 65.8%, specificity 42.5%) level were found to be significant in differantial diagnosis of malignant and benign pleural effusions.
This study was performed between 1998-1999 in Selçuk University Medical Faculty Department of Chest Diseases, 81 patients with pleural effusions were hospitalized and their CEA, CA 15-3, CA 19-9, CA 125, CA 72-4, AFP levels of pleural fluid and serum are investigated. The patients were seperated in two groups according to their etiologies malignant pleural effusions and benign pleural effusions. The pleural effusions with 41 cases were due to malignancy and most of them have lung cancer. In the other 40 cases the cause was nonmalignant origin. In pleural fluids, CEA level was 28.86 ± 37.34 ng/mL in malignant group and 1.42 ± 0.93 ng/mL in benign group (p< 0.001). CA 15-3 was 108.55 ± 150.43 U/mL, 15.91 ± 22.20 U/mL (p<0.001). CA 19-9 was 45.39 ± 137.26 U/mL, 14.03 ± 43.96 U/mL (p>0.05). CA 125 was 703.23 ± 491.51 U/mL, 565.30 ± 381.99 U/mL (p<0.05). AFP was 1.58 ± 1.39 ng/mL, 2.00 ± 3.04 ng/mL (p>0.05). CA 72-4 was 11.14 ± 23.83 U/mL, 0.67 ± 1.51 U/mL (p<0.001). In conclusion, CEA (sensitivity 56.0%, specificity 95.0%), CA 15-3 (sensitivity 53.6%, specificity 80.0%), CA 72-4 (sen- sitivity 26%, specificity 95%), CA 125 (sensitivity 65.8%, specificity 42.5%) level were found to be significant in differantial diagnosis of malignant and benign pleural effusions.
Açıklama
Anahtar Kelimeler
Plevral sıvı, tümör belirleyicileri, malignite, Pleural fluid, tumor markers, malignant
Kaynak
Solunum Hastalıkları
WoS Q Değeri
Scopus Q Değeri
Cilt
12
Sayı
Künye
Borazan, A., Bilgiçli, N., (2001). Malignite Kaynaklı Plevra Sıvılarında CEA, CA 15-3, CA 19-9, CA 125, CA 72-4 ve AFP Düzeyinin Tanısal Değeri. Solunum Hastalıkları, (12), 96-101.
