Koyunlarda karprofenin çoklu doz uygulamalarının hematolojik ve biyokimyasal parametreler üzerine etkisi
Yükleniyor...
Dosyalar
Tarih
2020
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Selçuk Üniversitesi Veteriner Fakültesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Bu araştırmanın amacı koyunlarda karprofenin farklı dozlarda tekrarlayan damar içi uygulamasını takiben hematolojik ve biyokimyasal parametrelere etkisini belirlemektir. Gereç ve Yöntem: Araştırmada, Akkaraman ırkı, 20 adet sağlıklı koyun kullanıldı. Çalışmada hayvanlar rastgele iki eşit gruba ayrıldı. Karprofen birinci grupta bulunan koyunlara 4 mg/kg dozda, ikinci grupta bulunan koyunlara ise 16 mg/kg dozda damar içi yolla günde bir defa 5 gün boyunca uygulandı. Kan örnekleri 0., 12., 24., 48., ve 120. saatlerde alınarak hemogram ve biyokimyasal panel değerlendirildi. Bulgular: Karprofenin doz grupları arasında hematolojik ve biyokimyasal parametrelerde herhangi farklılık belirlenmedi. 4 mg/kg grubunda en yüksek potasyum, kan üre nitrojen, aspartat aminotransferaz ve total protein seviyesi 12. saatte tespit edildi. 16 mg/kg grubunun en yüksek troponin-I seviyesi 12. saatte görüldü. Ayrıca 16 mg/kg dozda alyuvar, hemoglobin ve eritrosit düzeylerindeki düşüşün daha belirgin olduğu ve bu değişimin normal referans değerler içinde olduğu görüldü. Öneri: Sonuç olarak koyunlarda karprofenin 4 mg/kg ve 16 mg/kg dozlarda beş gün süre ile güvenle kullanılabileceği görüldü. Ancak güvenilirliğin histopatolojik ve moleküler düzeyde ortaya konulmasına ihtiyaç vardır.
Aim: The aim of this study was to determine the effects of carprofen on hematological and biochemical parameters following repeated intravenous administration of different doses. Materials and Methods: Twenty healthy Akkaraman sheep were enrolled. The animals were randomly divided into two equal groups. Carprofen was administered intravenously to the sheep in the first group at a dose of 4 mg/kg, and to the sheep in the second group at a dose of 16 mg/kg once a day for 5 days. To evaluation of hemogram and biochemical panel blood samples were taken before carprofen administration (0 hours) and 12, 24, 48, and 120 hours after administration. Results: There was no difference between hematological and biochemical parameters of different dose administration groups. The highest potassium, blood urea nitrogen, aspartate amino transferase and total protein levels were determined at the 12th hour after administration of 4 mg/kg carprofen. The highest troponin-I level was seen at the 12th hour after administration of 16 mg/kg carprofen. However, the decrease in the levels of red blood cells, hemoglobin and hematocrit at a dose of 16 mg/kg was more marked, this change was within the normal reference values. Conclusion: It has been observed that carprofen can be used safely at 4 mg/kg and 16 mg/kg doses for 5 days in the sheep. However, safety needs to confirm by histopathological and molecular studies.
Aim: The aim of this study was to determine the effects of carprofen on hematological and biochemical parameters following repeated intravenous administration of different doses. Materials and Methods: Twenty healthy Akkaraman sheep were enrolled. The animals were randomly divided into two equal groups. Carprofen was administered intravenously to the sheep in the first group at a dose of 4 mg/kg, and to the sheep in the second group at a dose of 16 mg/kg once a day for 5 days. To evaluation of hemogram and biochemical panel blood samples were taken before carprofen administration (0 hours) and 12, 24, 48, and 120 hours after administration. Results: There was no difference between hematological and biochemical parameters of different dose administration groups. The highest potassium, blood urea nitrogen, aspartate amino transferase and total protein levels were determined at the 12th hour after administration of 4 mg/kg carprofen. The highest troponin-I level was seen at the 12th hour after administration of 16 mg/kg carprofen. However, the decrease in the levels of red blood cells, hemoglobin and hematocrit at a dose of 16 mg/kg was more marked, this change was within the normal reference values. Conclusion: It has been observed that carprofen can be used safely at 4 mg/kg and 16 mg/kg doses for 5 days in the sheep. However, safety needs to confirm by histopathological and molecular studies.
Açıklama
Anahtar Kelimeler
Biyokimyasal, Hematolojik, Karprofen, Koyun, Yan etki, Biochemical, Carprofen, Hematological, Sheep, Side effect
Kaynak
Eurasian Journal of Veterinary Sciences
WoS Q Değeri
Scopus Q Değeri
Cilt
36
Sayı
3
Künye
Durna Çorum, D., Yıldız, R., (2020).Koyunlarda karprofenin çoklu doz uygulamalarının hematolojik ve biyokimyasal parametreler üzerine etkisi. Eurasian Journal of Veterinary Sciences, 36 (3), 166-171. DOI: 10.15312/EurasianJVetSci.2020.274
