Kafa Travma Modelinde Mannitol veya Hipertonik Salin Solüsyonlarının Etkilerinin Karşılaştırılması
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Date
2011
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Journal ISSN
Volume Title
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SPRINGER
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info:eu-repo/semantics/openAccess
Abstract
Deneysel kafa travmasında, % 20 mannitol, % 3 veya % 7
hipertonik salin solüsyonlarının, hemodinamik parametrelere,
intrakraniyal basınca ve elektroensefalografi üzerine olan etkilerini
karşılaştırılması amaçlandı. Bütün tavşanlara pariyetal bölgeden
bilateral kraniotomi yapılarak standart kafa travması uygulandı.
Rastgele 4 gruba ayrılan deneklerden; I. gruba tedavi uygulanmazken,
II. gruba % 20’lik mannitol, III. gruba % 3’lük hipertonik salin ve IV.
gruba % 7’lik hipertonik salin eşdeğer osmolar yükte intravenöz
uygulandı. Travmadan önce, travmadan 5 ve 60 dakika sonra;
elektroensefalografi, ortalama arter basıncı, kalp atım hızı ve
intrakraniyal basınç kayıtları alındı. Mannitol, % 3 ve % 7’lik hipertonik
salin solüsyonları intrakraniyal basınçdaki yükselmeyi çalışmanın
sonunda düşürdü (p<0.05). Fakat intrakraniyal basınç değerleri,
mannitol ve % 7’lik hipertonik salin gruplarında, diğer gruplardan
daha düşüktü (p<0.05). Elektroensefalografi skorları tüm gruplarda
travmadan sonra düştü (p<0.05). Çalışma sonunda % 3 ve % 7’lik
hipertonik salin grupları, travma öncesine benzer elektroensefalografi
skorlarına sahipti (p>0.05). Ortalama arter basınç ve kalp atım hızı,
bütün gruplarda travmadan sonra yükseldi (p<0.05). Çalışmanın
sonunda, ortalama arter basıncı sadece mannitol grubunda düşük
bulundu (p<0.05). Çalışmamız intrakraniyal hipertansiyonun
tedavisinde % 7 hipertonik salin solüsyonunun; mannitol kadar
etkili olduğunu, mannitole göre hemodinamik parametreleri daha
iyi koruduğunu, travmaya bağlı gelişen elektroensefalografi
anormalliklerini de daha iyi düzelttiğini gösterdi.
We aimed to compare the effects of 20 % mannitol, 3 % or 7 % hypertonic saline on hemodynamic parameters, intracranial pressure and electroencephalography in experimental head trauma. Bilateral craniotomy were carried out in the parietal region and standart head trauma was applied for all rabbits. The rabbits were randomly divided into four groups. In group I rabbits were only observed. In group II: 20 % mannitol, in group III: 3 % hypertonic saline and in group IV: 7 % hypertonic saline was administered intravenously to achieve similar osmolar load. Electroencephalography, mean arterial pressure, heart rate, intracranial pressure were recorded before trauma and 5 and 60 minutes after trauma. Increased intracranial pressure was significantly decreased by mannitol, 3 % and 7 % hypertonic saline solutions at the end of study (p<0.05). But intracranial pressure values of mannitol and 7 % hypertonic saline groups were lower than the other groups (p<0.05). The electroencephalography scores decreased after trauma in all groups (p<0.05). At end of the study, 3 % and 7 % hypertonic saline groups had similar electroencephalography scores with pretrauma scores (p>0.05). The mean arterial pressure and heart rates increased after trauma in all groups (p<0.05). Mean arterial pressure values were found lower only in mannitol group at end of the study (p<0.05). Our study showed that when used in intracranial hypertension treatment, 7 % hypertonic saline solution is as effective as mannitol, and preserves hemodynamic parameters, and normalizes traumatic electroencephalography abnormalities better than mannitol.
We aimed to compare the effects of 20 % mannitol, 3 % or 7 % hypertonic saline on hemodynamic parameters, intracranial pressure and electroencephalography in experimental head trauma. Bilateral craniotomy were carried out in the parietal region and standart head trauma was applied for all rabbits. The rabbits were randomly divided into four groups. In group I rabbits were only observed. In group II: 20 % mannitol, in group III: 3 % hypertonic saline and in group IV: 7 % hypertonic saline was administered intravenously to achieve similar osmolar load. Electroencephalography, mean arterial pressure, heart rate, intracranial pressure were recorded before trauma and 5 and 60 minutes after trauma. Increased intracranial pressure was significantly decreased by mannitol, 3 % and 7 % hypertonic saline solutions at the end of study (p<0.05). But intracranial pressure values of mannitol and 7 % hypertonic saline groups were lower than the other groups (p<0.05). The electroencephalography scores decreased after trauma in all groups (p<0.05). At end of the study, 3 % and 7 % hypertonic saline groups had similar electroencephalography scores with pretrauma scores (p>0.05). The mean arterial pressure and heart rates increased after trauma in all groups (p<0.05). Mean arterial pressure values were found lower only in mannitol group at end of the study (p<0.05). Our study showed that when used in intracranial hypertension treatment, 7 % hypertonic saline solution is as effective as mannitol, and preserves hemodynamic parameters, and normalizes traumatic electroencephalography abnormalities better than mannitol.
Description
23rd Annual Meeting of the European-Society-of-Intensive-Care-Medicine -- OCT 09-13, 2010 -- Barcelona, SPAIN
Keywords
Kafa travması, mannitol, hipertonik salin, intrakranial basınç, elektroensefelografi, Head injury, mannitol, hypertonic saline, intracranial pressure, electroencephalography
Journal or Series
Intensive Care Medicine
WoS Q Value
Q1
Scopus Q Value
Volume
27
Issue
1
Citation
Aygın, F., Yosunkaya, A., Tavlan, A., (2011). Kafa Travma Modelinde Mannitol veya Hipertonik Salin Solüsyonlarının Etkilerinin Karşılaştırılması. Intensive Care Medicine, 27(1), 1-5.
