18F-FDG (18-flor-florodeoksiglukoz) Pozitron Emisyon Tomografi/Bilgisayarlı Tomografi'nin Etkin Radyasyon Dozunun Değerlendirilmesi
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Date
2023
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Selçuk Üniversitesi, Fen Bilimleri Enstitüsü
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info:eu-repo/semantics/openAccess
Abstract
Bu çalışmanın amacı, yetişkin hastalarda [flor-18]-floro-2-deoksi-D-glukoz (18F-FDG)
kullanarak pozitron emisyon tomografisi/bilgisayarlı tomografi (PET/BT) taramasından organ dozlarını
ve tüm vücut etkin dozlarını tahmin etmek ve BT bileşeninin organ ve tüm vücut dozlarına katkısını
değerlendirmektir. Bu araştırmada ayrıca yetişkin hastalar için tüm vücut [18F-FDG] PET/BT taramasına
bağlı yaşam boyu atfedilebilir kanser riski (lifetime attributable risk-LAR) hesaplandı. Tüm vücudun [18FFDG] PET/BT taraması 204 yetişkin hastada (90 kadın ve 114 erkek) yapıldı. BT taramalarından harici
etkin dozlar, CT-Expo v2.5-Demo yazılımı kullanılarak hesaplandı. PET taramalarından elde edilen dâhili
etkin dozlar, Uluslararası Radyolojik Koruma Komitesi (ICRP) yayın 103'ten organ ağırlık faktörleri ve
ICRP yayın 106'dan 18F-FDG alım katsayıları kullanılarak tahmin edildi. Kanserin LAR'ları, İyonize
Radyasyonun Biyolojik Etkileri (BEIR VII) raporunda önerilen yaklaşım benimsenerek hesaplanmıştır.
BT, tüm vücut 18F-FDG PET/BT tarama protokolünde etkin doza birincil katkıda bulunandır. PET/BT
taramaları yüksek doz ve kanser geliştirme riski ile ilişkili olduğundan, herhangi bir tarama yapmadan
önce avantaj ve riskleri dengelemek önemliydi. Bu özellikle genç hastalar ve fazla kilolu olanlar için
önemlidir.
The objective of this study was to estimate organ doses and whole-body effective doses from positron emission tomography/computed tomography (PET/CT) scan using [fluorine-18]-fluoro-2-deoxyD-glucose (18F-FDG) in adult patients and to assess the CT component contribution to organ and wholebody doses. The lifetime attributable risk (LAR) of cancer associated with whole-body 18F-FDG PET/CT scan for adult patients was also estimated in this study. The [18F-FDG] PET/CT scan was conducted on 204 adult patients (90 females and 114 males). The CT-Expo v2.5-Demo software was used to estimate the external effective doses from the CT scans. The internal effective doses from the PET scans were estimated using the organ weighting factors provided by International Commision on Radiological Protection (ICRP) publication 103 and the uptake coefficients of 18F-FDG provided by ICRP publication 106. The LARs of cancer were computed by adopting the approximation suggested in the BEIR VII (Biological Effects of Ionizing Radiation) report. CT is the primary contributor to the effective dose in the whole-body 18F-FDG PET/BT scan protocol. Since PET/CT scans are related to a high dose and a risk of developing cancer, it was important to balance the advantages and risks before conducting any scans. This is especially important for younger patients and those who are overweight.
The objective of this study was to estimate organ doses and whole-body effective doses from positron emission tomography/computed tomography (PET/CT) scan using [fluorine-18]-fluoro-2-deoxyD-glucose (18F-FDG) in adult patients and to assess the CT component contribution to organ and wholebody doses. The lifetime attributable risk (LAR) of cancer associated with whole-body 18F-FDG PET/CT scan for adult patients was also estimated in this study. The [18F-FDG] PET/CT scan was conducted on 204 adult patients (90 females and 114 males). The CT-Expo v2.5-Demo software was used to estimate the external effective doses from the CT scans. The internal effective doses from the PET scans were estimated using the organ weighting factors provided by International Commision on Radiological Protection (ICRP) publication 103 and the uptake coefficients of 18F-FDG provided by ICRP publication 106. The LARs of cancer were computed by adopting the approximation suggested in the BEIR VII (Biological Effects of Ionizing Radiation) report. CT is the primary contributor to the effective dose in the whole-body 18F-FDG PET/BT scan protocol. Since PET/CT scans are related to a high dose and a risk of developing cancer, it was important to balance the advantages and risks before conducting any scans. This is especially important for younger patients and those who are overweight.
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Keywords
18F-FDG PET/BT taraması, CT-Expo yazılımı, organ dozu, ömür boyu atfedilebilir risk (LAR), tüm vücut etkin doz., : 18F-FDG PET/CT scan, CT-Expo software, organ dose, lifetime attributable risk (LAR), whole body effective dose
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Citation
Kessara A., (2023). 18F-FDG (18-flor-florodeoksiglukoz) Pozitron Emisyon Tomografi/Bilgisayarlı Tomografi'nin Etkin Radyasyon Dozunun Değerlendirilmesi (Doktora Tezi).
