The production and development of vaccines for Ornithobacterium rhinotracheale infection in commercial broilers
Yükleniyor...
Tarih
2011
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Selçuk Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Çalışmanın amacı bivalan inaktif Ornithobacte- rium rhinotracheale (0. rhinotracheale) aşıları hazırlamak, kan serumlarında antijenlere karşı antikorların titrelerini ölçmek ve etçi piliçlerde 0. rhinotracheale aşılarının etkin- liklerini belirlemektir. Gereç ve Yöntem: Bivalan inaktif O. rhinotracheale aşıları; alüminyum hidroksit (Al [OH] 3 ) mineral yağlı (MO), alüminyum hidroksit + ginseng (Al [OH] 3 +G) mineral yağ + ginseng (MO+ G) adjuvantları kullanılarak 0. rhinotra cheale serotip A ve B'den hazırlandı. Sterilite ve zararsızlık testlerinden sonra, etçi piliçlerde (ilk gün 0.1 mL doz ile bir kez aşılama ile) aşıların laboratuvar etkinlikleri ( varphi*elin*varphi / k * o ruma ve serolojik potens) kontrol edildi. Bulgular: Celinç sonuçlarına gore; etçi piliçlerde bütün aşıların 0 etkili olduğu bulundu. Adjuvant olarak min- eral yağ ve ginseng (MO + G) içeren aşı diğerlerine göre be- lirgin olarak daha yüksek humoral immune cevap oluşturdu. Öneri: Bu çalışmada, birinci günde etçi piliçlerin aşılanması 0. rhinotracheale enfeksiyonlarına karşı etkili şekilde koruyabildiği gösterilmiştir.
Aim: The purpose of this study was to prepare bivalent in- active Ornithobacterium rhinotracheale (0. rhinotarcheale) bacterin vaccines, to measure the levels of antibodies against antigens in blood sera and to determine the effica- cies of different 0. rhinotracheale vaccines in broilers. Materials and Methods: The bivalent inactivated 0. rhi- notracheale bacterin vaccines were prepared from 0. rhi- notracheale serotype A and B strains using aluminium hy- droxide ( Lambda l [OH] 3 ), mineral oil (MO), aluminium hydroxide + ginseng (Al [OH] 3 +G) and mineral oil + ginseng (MO+G). After the sterility and the safety tests, laboratory efficien- cies of vaccines (challange/protection and serological po- tency) were controlled on the broilers (vaccinated at first day with a dose of 0.1 mL). Results: According to the challenge results, all the vaccines were found to be effective as 100% for broilers. The vaccine containing mineral oil and ginseng (MO + G) as adjuvant induced significantly greater humoral immune response to the antigens than others. Conclusion: The study showed that vaccination of broilers chicken at the first day age may effectively protect against 0. rhinotracheale infections.
Aim: The purpose of this study was to prepare bivalent in- active Ornithobacterium rhinotracheale (0. rhinotarcheale) bacterin vaccines, to measure the levels of antibodies against antigens in blood sera and to determine the effica- cies of different 0. rhinotracheale vaccines in broilers. Materials and Methods: The bivalent inactivated 0. rhi- notracheale bacterin vaccines were prepared from 0. rhi- notracheale serotype A and B strains using aluminium hy- droxide ( Lambda l [OH] 3 ), mineral oil (MO), aluminium hydroxide + ginseng (Al [OH] 3 +G) and mineral oil + ginseng (MO+G). After the sterility and the safety tests, laboratory efficien- cies of vaccines (challange/protection and serological po- tency) were controlled on the broilers (vaccinated at first day with a dose of 0.1 mL). Results: According to the challenge results, all the vaccines were found to be effective as 100% for broilers. The vaccine containing mineral oil and ginseng (MO + G) as adjuvant induced significantly greater humoral immune response to the antigens than others. Conclusion: The study showed that vaccination of broilers chicken at the first day age may effectively protect against 0. rhinotracheale infections.
Açıklama
Anahtar Kelimeler
Ornithobacterium rhinotracheale, etçi piliç, aşı, ginseng, broiler chicken, vaccine
Kaynak
Eurasian Journal of Veterinary Sciences
WoS Q Değeri
Scopus Q Değeri
Cilt
27
Sayı
2
Künye
Erganiş, O., Hadimli, H. H., Kav, K., Sayın, Z., (2011). The production and development of vaccines for Ornithobacterium rhinotracheale infection in commercial broilers. Eurasian Journal of Veterinary Sciences, 27, (2), 99-105.
