Comparison of alfentanil and remifentanil at total intravenous anesthesia in short-term elective surgery [Kisa süreli cerrahi girişimlerde alfentanil ve re?ifentanilin tiva'da karşilaştirilmasi]
Yükleniyor...
Dosyalar
Tarih
2002
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
In our study, adding alfentanil as an opioid analgesic to propofol for total intravenous anesthesia in short-term elective surgery was compared to remifentanil. We aimed to study the anesthesia induction, maintenance and recovery characteristics of the two drugs. This study was carried out on 50 patients in ASA I-II group. They were between the ages of 18-60 and they were planned to be discharged from the hospital in 1-2 days. They were randomised into two groups, 20 ?g kg-1 alfentanil was given to group I and 1 ?g kg-1 remifentanil iv to group II patients as bolus injection, 2 ?g kg-1 min-1 alfentanil and 0.5 ?g kg-1 min-1 remifentanil iv infusion was also started respectively. Following this, these two group of patients were intubated by applying 2 mg kg-1 propofol+0.15 mg kg-1 vecuronium iv bolus and 90 ?g kg-1 min-1 iv propofol infusion. Alfentanil and remifentanil infusions were halfened 5 min after tracheal intubation and propofol infusion was decreased to 60 ?g kg-1 min-1 30 min after beginning. All patients were vetilated with 100 % O2 during the operation. Systolic arterial pressure, diastolic arterial pressure, mean arterial pressure and heart rate measurements were recorded before anesthesia, 1, 3, 5 min after remifentanil or alfentanil application, after the intubation and skin incision, and during surgery every 10. min. The haemodynamic and somatic responses to intubation-skin incision and surgical stimulation were identified. After operation, recovery time and adverse events were recorded. The response to tracheal intubation and skin incision was less in remifentanil group than in alfentanil group, statistically considerable difference was not identified. No differences were compared in the evaluation of times, seeing reponse to surgical. A smaller proportion of remifentanil patients than alfentanil patients had required addition opioid doses during maintenance (p < 0.05). When comparing the recovery period of each group, it was significantly shorter in the remifentanil group than in the alfentanil group (p < 0.05). These two groups were similar in the aspect of observing postoperative adverse events. As a result, we think that remifentanil can be prefered to alfentanil as an addition opioid agent in TIVA which is applied for short-term surgical procedures because a smaller remifentanil patients require a study opioid adjustments needed to treat light anesthesia responses and remifentanil provides rapid recovery.
Açıklama
Anahtar Kelimeler
Alfentanil, Propofol, Remifentanil, Total intravenous anesthesia
Kaynak
Anestezi Dergisi
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
10
Sayı
3
