The effects of exogenous estradiol and progesterone with melatonin on homocvsteine levels in ovariectomized rats

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dc.contributor.authorOztekin E.
dc.contributor.authorMogulkoc R.
dc.contributor.authorBaltaci A.K.
dc.contributor.authorOzturk B.
dc.contributor.authorTiftik A.M.
dc.date.accessioned2020-03-26T17:19:29Z
dc.date.available2020-03-26T17:19:29Z
dc.date.issued2007
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe study was carried out an 24 adult, Spraque-Dawfey strain of female rats. Group 1: Control group; Group 2: Ovariectomy group; Group 3 : supplemented with esradiol and progesterone after ovariectomy. Estradiol propionate 450?g/kg and medroxyprogesterone acetate 15mg/kg were supplemented a one time every week and melatonin injection (3mg/kg/rat) was made for four weeks. Serum homocysteine levels in groups 2 and 3 were significantly higher than those in groups 1 and 4. Homocysteine levels in groups 1 and 4 were not different from each other. The findings demonstrate that ovariectomy leads to a significant increase in homocysteine levels, but hormone (estradiol and progesterone) replacement could not prevent this increase. However, this increase was suppressed by exogenous melatonin supplementation.en_US
dc.identifier.endpage583en_US
dc.identifier.issn0019-6479en_US
dc.identifier.issue6en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage581en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/21883
dc.identifier.volume84en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofIndian Veterinary Journalen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleThe effects of exogenous estradiol and progesterone with melatonin on homocvsteine levels in ovariectomized ratsen_US
dc.typeReviewen_US

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