Novel natural agents from Lamiaceae family: An evaluation on toxicity and enzyme inhibitory potential linked to diabetes mellitus

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dc.contributor.authorEskandani, M.
dc.contributor.authorBahadori, M.B.
dc.contributor.authorZengin, Gökhan
dc.contributor.authorDinparast, L.
dc.contributor.authorBahadori, S.
dc.date.accessioned2020-03-26T19:32:02Z
dc.date.available2020-03-26T19:32:02Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractMedicinal plants are rich sources for drug discovery. Occurrence of Diabetes mellitus is increasing because of changes in human lifestyle. So, design or discovery of new and more effective and safer drugs is needed. At the present study, the enzyme inhibitory effects of methanol extracts of selected Lamiaceae species (Salvia syriaca L., Teucrium polium L., Phlomis olivieri Benth., Nepeta ispahanica Boiss., Scutellaria tomentosa Benth., Salvia limbata C.A. Mey., Teucrium orientale L., Salvia atropatana Bunge., Salvia nemorosa, Salvia multicaulis Vahl., Ajuga chamaecistus Ging. ex Benth., Mentha longifolia L. and Satureja khuzestanica) were evaluated. The enzyme inhibitory activities were tested against ?-amylase and ?-glucosidase, which are linked to diabetes. Also, brine shrimp lethality assay was used to determine the cytotoxicity of the extracts. All methanol extracts showed moderate to high inhibitory effects on the tested enzymes. Scutellaria tomentosa and Mentha longifolia exhibited the strongest ?-amylase and ?-glucosidase inhibitory effects, respectively. These activities were ranged from 0.135 to 0.291 mmol in ?-amylase assay and 1.256 to 6.640 mmol acarbose equivalents/g extract in ?-glucosidase assay. The highest cytotoxic effect was observed for the extract of S. syriaca roots (LC50 = 12.3 ?g/ml). The results suggest that these Lamiaceae species could be considered as a source of natural agents for the preparing of new pharmaceuticals and functional foods especially for the management of Diabetes mellitus. © 2016 Bentham Science Publishers.en_US
dc.identifier.doi10.2174/1573407212666151231183118en_US
dc.identifier.endpage38en_US
dc.identifier.issn1573-4072en_US
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage34en_US
dc.identifier.urihttps://dx.doi.org/10.2174/1573407212666151231183118
dc.identifier.urihttps://hdl.handle.net/20.500.12395/34293
dc.identifier.volume12en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherBentham Science Publishers B.V.en_US
dc.relation.ispartofCurrent Bioactive Compoundsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectDiabetes mellitusen_US
dc.subjectDrug discoveryen_US
dc.subjectLamiaceaeen_US
dc.subjectMenthaen_US
dc.subjectSalviaen_US
dc.titleNovel natural agents from Lamiaceae family: An evaluation on toxicity and enzyme inhibitory potential linked to diabetes mellitusen_US
dc.typeArticleen_US

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