Herediter anjioödemde kısa dönem danazol profilaksisi ile implant tedavisi: Vaka raporu
Yükleniyor...
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Selçuk Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Herediter anjioödem (HAÖ), C1 esteraz inhibitör proteininin konjenital eksikliğine bağlı olarak meydana gelen, nadir gözlenen, otozomal dominant bir hastalıktır. HAÖ atakları, spontan veya bir travmaya bağlı olarak, ekstremitelerde, yüzde, göğüste, hava yolunda veya karın bölgesinde şişlikler şeklinde meydana gelebilir. Dental işlemlerden önce, profilaksi amacıyla, androjenler, taze dondurulmuş plazma, C1 esteraz inhibitör protein konsantreleri ve antifibrinolitikler kullanılmaktadır. Bu vaka raporunda, danazol profilaksisi ile implant tedavisi uygulanan, herediter anjioödemli bir hasta sunulmaktadır. Preoperatif 3 gün 100 mg ve operasyon günü 200 mg danazol profilaksisi ile hastanın sol üst molar bölgesine bir adet dental implant yerleştirilmiş ve postoperatif 2 gün 100 mg danazol tedavisine devam edilmiştir. Hastada implant tedavisine bağlı olarak, akut veya post operatif herhangi bir atak görülmemiştir. Rekürrent anjio ödem hikayesi olan hastalar, dental implant cerrahisinden önce, C1 esteraz inhibitör protein eksikliği yönünden, dikkatle değerlendirilmelidir.dental tedavilerden önce danazol veya C1 inhibitörleri ile yapılan kısa dönem profilaksi uygulamaları, HAÖ hastalarında mortalite ve morbiditeyi azaltmakta oldukça faydalıdır.
Hereditary angioedema (HAE) is a rare autosomal dominant disorder resulting from the congenital deficiency of functional C1 esterase inhibitor protein. HAE is manifested by attacks of swelling of the extremities, face, trunk, airway, or abdominal viscera, occurring spontaneously or secondary to trauma. For dental procedures, preoperative prophylaxis has been performed with attenuated androgens, fresh frozen plasma (FFP), C1 esterase inhibitor protein concentrate and antifibrinolytics. . The aim of this case report was to present a dental implant treatment of patient with HAE and prevention the angioedema by administration of short-term danazol. Preoperative dose of danazol 100mg for 3 days was prescribed to patient. Dental implant to upper first right molar area was placed with an administration of danazol (200mg/ operation day) and 2 days postoperatively (100mg/d). There was no acute or post operative attack due to the implant therapy in the patient. Patients with a history of recurrent angioedema should be evaluated for functional C1 esterase inhibitor protein deficiency before undergoing oral surgeries. Short- term danazol or C1 inhibitor prophylaxis before dental treatments is useful to reduce mortalty and morbidity in HAÖ patients.
Hereditary angioedema (HAE) is a rare autosomal dominant disorder resulting from the congenital deficiency of functional C1 esterase inhibitor protein. HAE is manifested by attacks of swelling of the extremities, face, trunk, airway, or abdominal viscera, occurring spontaneously or secondary to trauma. For dental procedures, preoperative prophylaxis has been performed with attenuated androgens, fresh frozen plasma (FFP), C1 esterase inhibitor protein concentrate and antifibrinolytics. . The aim of this case report was to present a dental implant treatment of patient with HAE and prevention the angioedema by administration of short-term danazol. Preoperative dose of danazol 100mg for 3 days was prescribed to patient. Dental implant to upper first right molar area was placed with an administration of danazol (200mg/ operation day) and 2 days postoperatively (100mg/d). There was no acute or post operative attack due to the implant therapy in the patient. Patients with a history of recurrent angioedema should be evaluated for functional C1 esterase inhibitor protein deficiency before undergoing oral surgeries. Short- term danazol or C1 inhibitor prophylaxis before dental treatments is useful to reduce mortalty and morbidity in HAÖ patients.
Açıklama
Anahtar Kelimeler
C1 esteraz inhibitör protein eksikliği, danazol, herediter anjio ödem, C1 esterase inhibitor protein deficiency, danazol, hereditary angioedema
Kaynak
Selçuk Üniversitesi Diş Hekimliği Fakültesi Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
6
Sayı
2
Künye
Gönen, Z. B., Doğruel, F., Asan, C. Y., Kaynar, L., Çetin, M., (2019). Herediter anjioödemde kısa dönem danazol profilaksisi
ile implant tedavisi: Vaka raporu. Selçuk Üniversitesi Diş Hekimliği Fakültesi Dergisi, 6 (2), 190-195. Doi: 10.15311/selcukdentj.384245
