Evaluation of Relationship Between Serum Neopterin, Cystatin C and Coronary Heart Disease

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dc.contributor.authorAbuşoğlu, Sedat
dc.contributor.authorToklu, Oğuzhan
dc.contributor.authorÇelik, Hüseyin Tuğrul
dc.contributor.authorAkgöl, Evren
dc.contributor.authorEllidağ, Hamit Yaşar
dc.contributor.authorArslan, Banu
dc.contributor.authorYeşil, Murat
dc.date.accessioned2020-03-26T19:24:07Z
dc.date.available2020-03-26T19:24:07Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAim: It has been reported that neopterin, a key molecule for immun response organization, is released from active macrophages of atheromatous plaque and useful for cardiovascular risk stratification. The aim of this study was to investigate serum cystatin C and neopterin levels in patients with coronary artery disease and examine the relationship between these markers and cardiovascular risk factors. Material and Method: Coronary artery disease group and control group consisted of 75 subjects (61 males, 14 females, mean age 60.5-1 and 50 subjects (25 males, 25 females, mean age 56.9-10), respectively. Results: Serum neopterin concentrations were higher in coronary artery disease group compared to control group, A negative correlation was established between neopterin and high density lipoprotein cholesterol. Also, there was a positive correlation between Gensini score and cystatin C and neopterin. Discussion: Serum cystatin C and neopterin concentrations might be useful markers for determining the coronary artery disease's severity, According to this study, neopterin seems to be a stronger indicator of cardiovascular diseases compared to cystatin C. The positive correlation between Gensini score and the biochemical markers offers us a potential use of these markers in evaluating the disease's severity.en_US
dc.identifier.doi10.4328/JCAM.2493en_US
dc.identifier.endpage31en_US
dc.identifier.issn1309-0720en_US
dc.identifier.issn1309-2014en_US
dc.identifier.issue1en_US
dc.identifier.pmid#YOKen_US
dc.identifier.startpage27en_US
dc.identifier.urihttps://dx.doi.org/10.4328/JCAM.2493
dc.identifier.urihttps://hdl.handle.net/20.500.12395/33581
dc.identifier.volume7en_US
dc.identifier.wosWOS:000376566300007en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherDERMAN MEDICAL PUBLen_US
dc.relation.ispartofJOURNAL OF CLINICAL AND ANALYTICAL MEDICINEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectNeopterinen_US
dc.subjectCystatin Cen_US
dc.subjectAtherosclerosisen_US
dc.subjectCoronary Artery Diseaseen_US
dc.subjectGensini Scoreen_US
dc.titleEvaluation of Relationship Between Serum Neopterin, Cystatin C and Coronary Heart Diseaseen_US
dc.typeArticleen_US

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