Effect of ceftriaxone on blood pressure, respiration and its analgesic and antipyretic activities
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Dosyalar
Tarih
2012
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Selçuk Ünivesitesi Veterinerlik Fakültesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Araştırmanın amacı seftriaksonun köpeklerde kan basıncı ve solunuma etkisini aratırmaktır. Ayrıca seftriaksonun fare ve ratlarda anajezik ve antipretik etkiliği de araştırıldı. Gereç ve Yöntem: Faklı dozlarda seftriaksonun (26.66, 53.33, 106.66 mg/kg, IV) anestezi altındaki köpeklerde kan basıncı ve solunuma etkisi belirlendi. İki farklı dozda seftriaksonun ise fare ve ratlarda anajezik ve antipretik etkinliği belirlendi. Bulgular: Seftriaksonun anestezi altındaki köpeklerin kan basıncı ve solunuma etkisinin olmadığı belirlendi. Ancak seftriaksonun (260 ve 520 mg/kg) dört saat süresince analjezik ve 180 ile 360 mg/kg dozlarda sırasıyla 2.5 ve 1.5 saat süresince antipretik etkinlik gösterdiği belirlendi. Öneri: Seftriakson bakterial ve ateşli enfeksiyonlarda antibakteriyel, analjezik ve antipretik etkinliğinden dolayı tercih edilebilir.
Aim: The aim of this study was to determine the effect of ceftriaxone on blood pressure and respiration in dog. In addition, analgesic and antipyretic activities of ceftriaxone were investigated in mice and rats. Materials and Methods: Effect of different doses of ceftriaxone (26.66, 53.33, 106.66 mg/kg, IV) on blood pressure and respiration rate were determined in anesthetized dogs. Analgesic and antipyretic activities of two different doses of ceftriaxone were investigated in mice and rats, respectively. Results: Ceftriaxone had no effect on blood pressure and rate of respiration in anesthetized dogs. However, ceftriaxone (260 and 520 mg/kg) had a significant analgesic effect for four hours and had a significant antipyretic effect at 2.5 and 1.5 hours at doses of 180 and 360 mg/kg, respectively. Conclusion: Ceftriaxone is preferable in bacterial infections or feverish conditions owing to its antibacterial, antipyretic and analgesic activities.
Aim: The aim of this study was to determine the effect of ceftriaxone on blood pressure and respiration in dog. In addition, analgesic and antipyretic activities of ceftriaxone were investigated in mice and rats. Materials and Methods: Effect of different doses of ceftriaxone (26.66, 53.33, 106.66 mg/kg, IV) on blood pressure and respiration rate were determined in anesthetized dogs. Analgesic and antipyretic activities of two different doses of ceftriaxone were investigated in mice and rats, respectively. Results: Ceftriaxone had no effect on blood pressure and rate of respiration in anesthetized dogs. However, ceftriaxone (260 and 520 mg/kg) had a significant analgesic effect for four hours and had a significant antipyretic effect at 2.5 and 1.5 hours at doses of 180 and 360 mg/kg, respectively. Conclusion: Ceftriaxone is preferable in bacterial infections or feverish conditions owing to its antibacterial, antipyretic and analgesic activities.
Açıklama
Anahtar Kelimeler
Seftriakson, kan basıncı, solunum, analjezik, antipretik, Ceftriaxone, blood pressure, respiration, analgesic, antipyretic
Kaynak
Eurasian Journal of Veterinary Sciences
WoS Q Değeri
Scopus Q Değeri
Cilt
28
Sayı
1
Künye
Aboubakr, M., Elsayed, M., Elkomy, A., (2012). Effect of ceftriaxone on blood pressure, respiration and its analgesic and antipyretic
activities. Eurasian Journal of Veterinary Sciences, 28 (1), 41-46.
