Phytotoxic, Cytotoxic and Insecticidal Activities of Chrysophthalmum dichotomum Boiss. and Heldr

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dc.contributor.authorAyaz, Fatma
dc.contributor.authorKucukboyaci, Nurgun
dc.contributor.authorBani, Baris
dc.contributor.authorSener, Bilge
dc.contributor.authorChoudhary, Muhammad Iqbal
dc.date.accessioned2020-03-26T19:55:08Z
dc.date.available2020-03-26T19:55:08Z
dc.date.issued2018
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: Chrysophthalmum dichotomum Boiss. and Heldr. (Asteraceae) is an endemic herbaceous plant to Southern part of Turkey. Aim: To investigate in vitro phytotoxic, cytotoxic and insecticidal activities of C. dichotomum. Methods: The MeOH extract of C. dichotomum was fractionated through subsequent solvent extractions in increasing polarity with n-hexane, chloroform and n-butanol. The MeOH extract and its fractions were evaluated for their biological acitivities using in vitro screening bioassays such as cytotoxicity on brine shrimps, phytotoxicity against Lemna minor and insecticidal activity against Rhyzopertha dominica and Tribolium castaneum. Results: The n-hexane and chloroform fractions showed significant phytotoxic activity (100 % growth inhibition) at 1000 mu g/ml against L. minor. The brine shrimp lethality test revealed that the chloroform and remaining water fractions of C. dichotomum have moderate and positive lethality with LD50 values of 169.48 and 46.26 mu g/mL, respectively. In addition, the chloroform and n-butanol fractions had low and moderate insecticidal activity with 20 and 40 % of mortality against Tribolium castaneum, respectively. Conclusion: This study demonstrates that C. dichotomum consists of bioactive constituents responsible for phytotoxicity, cytotoxicity on brine shrimps and insecticidal activity.en_US
dc.description.sponsorship[TUBITAK-2214/A]; [TUBITAK-2211/A]en_US
dc.description.sponsorshipThis study was supported by TUBITAK-2214/A and ICCBS-HEJ. TUBITAK-2214/A, TUBITAK-2211/A and ICCBS-HEJ.en_US
dc.identifier.doi10.5530/ijper.52.4s.105en_US
dc.identifier.endpageS256en_US
dc.identifier.issn0019-5464en_US
dc.identifier.issue4en_US
dc.identifier.startpageS252en_US
dc.identifier.urihttps://dx.doi.org/10.5530/ijper.52.4s.105
dc.identifier.urihttps://hdl.handle.net/20.500.12395/36859
dc.identifier.volume52en_US
dc.identifier.wosWOS:000454952200013en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherASSOC PHARMACEUTICAL TEACHERS INDIAen_US
dc.relation.ispartofINDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectChrysophthalmum dichotomumen_US
dc.subjectAsteraceaeen_US
dc.subjectPhytotoxicity against Lemna minoren_US
dc.subjectCytotoxicity on brine shrimpsen_US
dc.subjectInsecticidal activityen_US
dc.titlePhytotoxic, Cytotoxic and Insecticidal Activities of Chrysophthalmum dichotomum Boiss. and Heldren_US
dc.typeArticleen_US

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