Evaluation of Antihyperlipidemic Effect of Rosemary Oil in Streptozotocin-induced Diabetic Rats
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Dosyalar
Tarih
2024 Mart
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Selçuk Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Öz Amaç: Bu çalışmada streptozotosin ile diyabet oluşturulan ratlarda lipit profil üzerine rosemary yağının potansiyel etkileri incelenmiştir. Gereç ve Yöntem: Çalışmada otuz iki adet yetişkin erkek Wistar Albino rat kullanıldı. Çalışma grupları; kontrol grubu (C, n=6), rosemary grubu (R, n=6), diyabet grubu (STZ, n=10) ve diyabet+rosemary grubu (STZ+R, n=10) olarak oluşturuldu. Rosemary yağı alan gruplara üç hafta süreyle günlük 200 mg/ kg oral dozunda rosemary yağı uygulandı. Diyabet iki gün üst üste günlük tek doz olarak 0.1 M sitrat bufferda (pH 4.5) 40 mg/kg dozunda subkutan streptozotosin enjeksiyonu ile oluşturuldu. Üç haftanın sonunda, tüm hayvanlardan alınan kan örneklerinde lipit parametreleri değerlendirildi. Bulgular: Bu çalışmada, diyabet grubunda kontrol grubuyla karşılaştırıldığında plazma trigliserit, total kolesterol ve LDL-kolesterol seviyeleri önemli ölçüde yükselirken, plazma HDL-kolesterol seviyeleri de önemli ölçüde azaldı. Bununla birlikte, rosemary yağının streptozotosin ile indüklenen diyabetik ratlara uygulanması ile plazma trigliserit, total kolesterol ve LDL-kolesterol seviyelerinde önemli bir azalma gözlenirken, plazma HDL-kolesterolünde belirgin bir artış gözlendi. Öneri: Mevcut bulgular sonucunda rosemary yağının antihiperlipidemik özelliklere sahip olabileceği ve diyabet tedavisinde bitkisel ilaç olarak kullanılabileceği sonucuna varılmıştır.
Abstract Aim: In this study, the potential effects of rosemary oil on the lipid profile in streptozotocin-induced diabetic rats were examined. Materials and Methods:In this study,thirty-two adult maleWistarAlbino rats were used. Working groups were consisted as follows: control group (C, n=6), rosemary group (R, n=6), diabetes group (STZ, n=10) and diabetes+rosemary group (STZ+R, n=10). The rosemary oil was administered at oral dosage of 200 mg/kg daily for duration of three weeks in the groups receiving rosemary oil. Diabetes was performed by subcutaneous injections of streptozotocin at dosage of 40 mg/kg in 0.1 M citrate buffer (pH 4.5) for two consecutive days as a single daily dose. At the end of three weeks, blood samples collected from the all animals were assessed lipid parameters. Results: In this study, plasma levels of triglyceride, total cholesterol, and LDLcholesterol significantly elevated, alongside plasma HDL-cholesterol levels in diabetes group significantly reduced compared to the control group. However, upon the application of rosemary oil to streptozotocin-induced diabetic rats, a substantial decrease in plasma triglyceride, total cholesterol, and LDLcholesterol levels was observed, while plasma HDL-cholesterol notably increased. Conclusion:As a result ofthe currentfindings, itis concluded that rosemary oil may have antihiperlipidemic properties and could be used as a phytomedicine for the treatment of diabetes.
Abstract Aim: In this study, the potential effects of rosemary oil on the lipid profile in streptozotocin-induced diabetic rats were examined. Materials and Methods:In this study,thirty-two adult maleWistarAlbino rats were used. Working groups were consisted as follows: control group (C, n=6), rosemary group (R, n=6), diabetes group (STZ, n=10) and diabetes+rosemary group (STZ+R, n=10). The rosemary oil was administered at oral dosage of 200 mg/kg daily for duration of three weeks in the groups receiving rosemary oil. Diabetes was performed by subcutaneous injections of streptozotocin at dosage of 40 mg/kg in 0.1 M citrate buffer (pH 4.5) for two consecutive days as a single daily dose. At the end of three weeks, blood samples collected from the all animals were assessed lipid parameters. Results: In this study, plasma levels of triglyceride, total cholesterol, and LDLcholesterol significantly elevated, alongside plasma HDL-cholesterol levels in diabetes group significantly reduced compared to the control group. However, upon the application of rosemary oil to streptozotocin-induced diabetic rats, a substantial decrease in plasma triglyceride, total cholesterol, and LDLcholesterol levels was observed, while plasma HDL-cholesterol notably increased. Conclusion:As a result ofthe currentfindings, itis concluded that rosemary oil may have antihiperlipidemic properties and could be used as a phytomedicine for the treatment of diabetes.
Açıklama
Anahtar Kelimeler
Diyabet, lipit profil, rat, rosemary, Diabetes, lipid profile, rats
Kaynak
Eurasian Journal of Veterinary Sciences
WoS Q Değeri
Scopus Q Değeri
Cilt
40
Sayı
1
Künye
Uluışık, D., Keskin, E., (2024). Evaluation of Antihyperlipidemic Effect of Rosemary Oil in Streptozotocin-induced Diabetic Rats. Eurasian Journal of Veterinary Sciences, 40(1), 10-15. DOI: 10.15312/EurasianJVetSci.2024.420
