Interleukin-1 receptor antagonist levels in gingival crevicular fluid and serum in nonsmoking women with preterm low birth weight and intrauterine growth retardation

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dc.contributor.authorKayar, Nezahat Arzu
dc.contributor.authorAlptekin, Nilgün Özlem
dc.contributor.authorHaliloğlu, Seyfullah
dc.date.accessioned2020-03-26T19:08:23Z
dc.date.available2020-03-26T19:08:23Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: The aim of this study was to evaluate interleukin (IL)-1 ? and IL-1 receptor antagonist (IL-1ra) levels in gingival crevicular fluid (GCF) and serum (S) in nonsmoking women with normal birth (NB), preterm low birth weight (PLBW), and intra-uterine growth retardation (IUGR). Materials and Methods: In this unmatched case-control study design, 64 women with NB, 45 women with PLBW, and 47 women with IUGR were recruited within 24 h delivery. Clinical periodontal parameters were recorded. IL-1 ? and IL-1ra levels in GCF (pg/30 s) and serum (pg/ml) of were evaluated using commercial enzyme immunoassay and ELISA kits. Results: Greater pocket depth and clinical attachment loss were observed in PLBW and IUGR women than in NB women (P < 0.05). The total amounts of IL-1ra and IL-? of GCF were higher levels in NB women than PLBW and IUGR women (P < 0.05). The lowest total amount of IL-1ra of GCF was found in IUGR women (P < 0.05). The concentrations of IL-1ra in serum samples were not statistically significant for any of the study groups (P > 0.05). Conclusion: It can be suggested that worse periodontal conditions and the low levels of IL-1ra in GCF may be an important factor in adverse pregnancy outcomes. © 2015 Dental Investigations Society.en_US
dc.identifier.doi10.4103/1305-7456.149655en_US
dc.identifier.endpage116en_US
dc.identifier.issn1305-7456en_US
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage109en_US
dc.identifier.urihttps://dx.doi.org/10.4103/1305-7456.149655
dc.identifier.urihttps://hdl.handle.net/20.500.12395/32832
dc.identifier.volume9en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherDental Investigations Societyen_US
dc.relation.ispartofEuropean Journal of Dentistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCytokine(s)en_US
dc.subjectGingival crevicular fluiden_US
dc.subjectPeriodontal-systemic disease interactionsen_US
dc.subjectSerumen_US
dc.titleInterleukin-1 receptor antagonist levels in gingival crevicular fluid and serum in nonsmoking women with preterm low birth weight and intrauterine growth retardationen_US
dc.typeArticleen_US

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