Changes in Serum Levels of ADMA, SDMA and L-NMMA with Helicobacter Pylori Eradication

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dc.contributor.authorBaldane, Süleyman
dc.contributor.authorKorkmaz, Hüseyin
dc.contributor.authorİpekci, Süleyman Hilmi
dc.contributor.authorSözen, Mehmet
dc.contributor.authorAbuşoğlu, Sedat
dc.contributor.authorAkar, Tarık
dc.contributor.authorÜnlü, Ali
dc.date.accessioned2020-03-26T19:34:15Z
dc.date.available2020-03-26T19:34:15Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: Increased asymmetric dimethylarginine (ADMA) levels are associated with reduced nitric oxide (NO) levels in many systems, particularly the cardiovascular system, and cause adverse effects. The objective of this study is to evaluate the effect of eradication therapy in patients infected with Helicobacter pylori (H. pylori) on the serum level of ADMA and other metabolic products of methylarginine. Methods: Patients who were found positive both in urea breath tests and stool antigen tests were considered to have H. pylori infection. These patients received eradication therapy for 14 days (twice daily pantoprazole 40 mg, twice daily amoxicillin 1000 mg, and twice daily clarithromycin 500 mg). Blood samples were taken to measure serum ADMA, symmetric dimethylarginine (SDMA), and N-monomethyl-Larginine (L-NMMA) levels before eradication therapy and 3 months after the therapy for patients for whom eradication was achieved. Results: A total of 23 of the 45 patients included in the study were female, whereas 22 were male. The mean age of the patients was 32.4 +/- 8 years. Significant reductions in the serum ADMA, SDMA, and L-NMMA levels of the patients were observed post-eradication therapy versus pre-eradication therapy. Conclusion: This study demonstrated significant reductions in serum ADMA, SDMA, and L-NMMA levels with H. pylori eradication. Further extensive long-term studies are needed to evaluate the positive effects that reduced serum ADMA, SDMA, and L-NMMA levels after H. pylori eradication can have on all systems, particularly the cardiovascular system.en_US
dc.identifier.citationBaldane, S., Korkmaz, H., İpekci, S. H., Sözen, M., Abuşoğlu, S., Akar, T., Ünlü, A., (2017). Changes in Serum Levels of ADMA, SDMA and L-NMMA with Helicobacter Pylori Eradication. Journal of Academic Research In Medicine-Jarem, 7(3), 132-134. DOI: 10.5152/jarem.2017.1331
dc.identifier.doi10.5152/jarem.2017.1331en_US
dc.identifier.endpage134en_US
dc.identifier.issn2146-6505en_US
dc.identifier.issn2147-1894en_US
dc.identifier.issue3en_US
dc.identifier.pmid#YOKen_US
dc.identifier.startpage132en_US
dc.identifier.urihttps://dx.doi.org/10.5152/jarem.2017.1331
dc.identifier.urihttps://hdl.handle.net/20.500.12395/34865
dc.identifier.volume7en_US
dc.identifier.wosWOS:000419258100007en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isotren_US
dc.publisherAVESen_US
dc.relation.ispartofJournal of Academic Research In Medicine-Jaremen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectHelicobacter pylorien_US
dc.subjectasymmetric dimethylarginineen_US
dc.subjectsymmetric dimethylarginineen_US
dc.subjectN-monomethyl-L-arginineen_US
dc.titleChanges in Serum Levels of ADMA, SDMA and L-NMMA with Helicobacter Pylori Eradicationen_US
dc.typeArticleen_US

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