Myelomeningoceles and Meningoceles: A Clinicopathologic Study of 43 Cases

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dc.contributor.authorKarabagli, Pinar
dc.contributor.authorGurcan, Tugba
dc.contributor.authorCelik, Zeliha Esin
dc.contributor.authorKarabagli, Hakan
dc.date.accessioned2020-03-26T18:51:40Z
dc.date.available2020-03-26T18:51:40Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: The purpose of the study both meningocele and myelomeningocele reviewing the clinical and pathological findings as well as to discuss the pathological diagnosis. Material and methods: Meningocel and myelomeningocele were retrived from the pathology files. Forty three cases with detailed clinical and radiological data were selected. Masson's trichrome performed on original sections from paraffin blocks. All sections from each case were reviewed. Results: There were 34 cases of myelomeningocele, 9 cases of meningocele. F/M ratio was 1.2 to 1. The age range of patients were from newborn to 4 months. 90% of cases were in the lumbosacral region. 31 cases of myelomeningoceles, and 3 cases of meningoceles were hydrocephalus. Chiari II malformation was seen in 88% of myelomeningocels and in 22% of meningoceles. Three patients had a clubfoot deformity. Microscopically, epithelial changes included ulceration, loss of appendages. Mesodermal findings included fibrosis (90% of cases), adipose tissue (62%), hypertrophic smooth muscle (18%), skeletal muscle (4%) and increased numbers of blood vessels (79%). Subepidermal calcification was noted in 2 cases. Neuroectodermal features, neuropil-like matrix and ependymal lining were noted in 34 and 15 cases respectively. Nerve fibers were identified varied from easily identifiable large myelinated nerve trunks to slightly increased numbers of fibers in 83% of the cases. Conclusion: Both clinical and pathological differences were seen among myelomeningoceles. These malformations involve ectoderm, neuroectoderm, and mesoderm. Definition of the pathological aspects of dysraphism will potentiate the understanding of these anomalies.en_US
dc.identifier.endpage345en_US
dc.identifier.issn1302-1664en_US
dc.identifier.issue2en_US
dc.identifier.startpage335en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/31011
dc.identifier.volume31en_US
dc.identifier.wosWOS:000343369600015en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherJOURNAL NEUROLOGICAL SCIENCESen_US
dc.relation.ispartofJOURNAL OF NEUROLOGICAL SCIENCES-TURKISHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectMyelomeningoceleen_US
dc.subjectmeningoceleen_US
dc.subjectpathologyen_US
dc.subjectChiari II malformationen_US
dc.subjectClubfoot deformityen_US
dc.titleMyelomeningoceles and Meningoceles: A Clinicopathologic Study of 43 Casesen_US
dc.typeArticleen_US

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