Effects of ?-endorphin on plasma glucose levels
| dc.contributor.author | Akalın, Pınar Peker | |
| dc.contributor.author | Başpınar, Nuri | |
| dc.date.accessioned | 2020-03-26T18:06:05Z | |
| dc.date.available | 2020-03-26T18:06:05Z | |
| dc.date.issued | 2010 | |
| dc.department | Selçuk Üniversitesi | en_US |
| dc.description.abstract | Healthy, and insulin-deficient (streptozotocin-induced diabetic, STZ) Sprague-Dawley rats were used to investigate the effects of different doses of ?-endorphin (25 and 50 ?g/kg) on plasma ?-endorphin, insulin, glucagon, and glucose levels at 15- and 30-min time points. In experimental groups, plasma ?-endorphin levels were higher at the 15-min than at the 30-min time point in healthy rats; however, in STZ-diabetic rats, ?-endorphin levels were lower at 15 min than at 30 min, indicating that intraperitoneal absorption of ?-endorphin differed between healthy and insulin-deficient rats. ?-endorphin did not affect plasma glucose, insulin, or glucagon at either dose in the healthy group. In the insulin-deficient rats, ?-endorphin at 50 ?g/kg reduced plasma glucose levels at the 30-min time point compared to the 25 ?g/kg dose, without affecting plasma insulin. Moreover, ?-endorphin at 50 ?g/kg decreased plasma glucagon levels at the 15-min time point in comparison to the 25 ?g/kg dose in insulin-deficient rats. Plasma glucose levels may be reduced in insulin-deficient rats at high ?-endorphin levels regardless of insulin status. | en_US |
| dc.identifier.endpage | 282 | en_US |
| dc.identifier.issn | 0042-4870 | en_US |
| dc.identifier.issue | 2 | en_US |
| dc.identifier.scopusquality | N/A | en_US |
| dc.identifier.startpage | 277 | en_US |
| dc.identifier.uri | https://hdl.handle.net/20.500.12395/25617 | |
| dc.identifier.volume | 54 | en_US |
| dc.indekslendigikaynak | Scopus | en_US |
| dc.language.iso | en | en_US |
| dc.relation.ispartof | Bulletin of the Veterinary Institute in Pulawy | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.selcuk | 20240510_oaig | en_US |
| dc.subject | ?-Endorphin | en_US |
| dc.subject | Diabetes mellitus | en_US |
| dc.subject | Glucagon | en_US |
| dc.subject | Glucose | en_US |
| dc.subject | Insulin | en_US |
| dc.subject | Rats | en_US |
| dc.title | Effects of ?-endorphin on plasma glucose levels | en_US |
| dc.type | Article | en_US |
