Bridelia speciosa müll.Arg. stem bark extracts as a potential biomedicine: From tropical western africa to the pharmacy shelf

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dc.contributor.authorMahomoodally, Mohamad Fawzi
dc.contributor.authorSinan, K. I.
dc.contributor.authorBene, K.
dc.contributor.authorZengin, Gökhan
dc.contributor.authorOrlando, G.
dc.contributor.authorMenghini, L.
dc.contributor.authorVeschi, S.
dc.date.accessioned2020-03-26T20:20:43Z
dc.date.available2020-03-26T20:20:43Z
dc.date.issued2020
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBridelia species have been used in traditional African medicine for the management of diverse human ailments. In the current work, the detailed phytochemical profiles of the extracts of the stem bark of B. speciosa were evaluated and the antioxidant and enzyme inhibitory properties of the extracts were assessed. The anti-bacterial and anti-mycotic effects of the extracts were evaluated against selected pathogen strains. Additionally, the anti-proliferative effects were studied on the liver cancer HepG2 cell line. Finally, the putative protective effects were assessed on isolated rat liver that was challenged with lipopolysaccharide (LPS). The results revealed the presence of 36 compounds in the ethyl acetate extract, 44 in the methanol extract, and 38 in the water extract. Overall, the methanol extract showed the highest antioxidant activity, particularly in LPS-stimulated rat liver. Additionally, this extract exerted the highest antimycotic effect on C. albicans, whereas the water extract showed a promising anti-proliferative effect on liver cancer HepG2 cells. The methanol extract was also the most active as enzyme inhibitor, against acetylcholinesterase and butyrylcholinesterase. The current study appraises the antioxidant and enzyme inhibition properties of B. speciosa methanol extract and showed that this specie could be a promising source of biologically active phytochemicals, with potential health uses. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.en_US
dc.description.sponsorshipFAR 2019 Ministerstvo Zdravotnictví Ceské Republiky: AZV 17–31269Aen_US
dc.description.sponsorshipFunding: The study was supported by Italian Ministry of University funds (FAR 2019) granted to Prof. Claudio Ferrante. The contribution of V.H. was supported by the grant of the Czech Ministry of Health (AZV 17–31269A).en_US
dc.identifier.doi10.3390/antiox9020128en_US
dc.identifier.issn2076-3921en_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://dx.doi.org/10.3390/antiox9020128
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38652
dc.identifier.volume9en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMDPI AGen_US
dc.relation.ispartofAntioxidantsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAnti-proliferativeen_US
dc.subjectAntimicrobialen_US
dc.subjectAntioxidanten_US
dc.subjectBridelia speciosaen_US
dc.subjectPhenolic compoundsen_US
dc.titleBridelia speciosa müll.Arg. stem bark extracts as a potential biomedicine: From tropical western africa to the pharmacy shelfen_US
dc.typeArticleen_US

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