Cellular Cardiomyoplasty: Arterial Cells-Stem Cells Transplantation

Cardiovascular disease is the leading cause of mortality and morbidity all over the world. Current treatments in cardiovascular disease do not prevent the cell loss and have no contribution to regeneration, although these therapies provided an improvement in the survival. Cardiac repair by stem cells promises regenerating damaged myocardium by reconstructing the injured heart from its component parts. Up to date, variety of stem cells including BM mononuclear, adipocyte progenitor cells, fibroblasts, smooth and strait muscle cells, circulating progenitor cells, embryonic stem cells, cord blood cells etc., have been used for cardiac repair experimentally and some at clinically. There is no consensus which cell should be use for cardiac repair. We strongly suggest that vascular wall cells seem to be a good candidate for cardiomyoplasty. © Springer Science+Business Media B.V. 2012.