Role of Tenascin-C in the differential diagnosis of small round blue cell tumors
Küçük Resim Yok
Tarih
2015
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Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Giriş: Bu çalışma; küçük yuvarlak mavi hücreli tümörlerde, serum tenascin-C düzeylerinin teşhis, tedavi ve takiplerdeki yerinin değerlendirilmesi amacıyla planlanmıştır. Gereç ve yöntem: Bu prospektif çalışmaya; 40 hasta ve kontrol grubu olarak 30 sağlıklı çocuk alındı. Hastalardan; tanı anında, tedavinin 3. ve 6. aylarında ve tedavi bittikten sonraki 3. ayda toplam dört defa, kontrol grubundan ise; bir defa serum örneği alınarak tenascin-C düzeyleri ölçüldü. Bulgular: Tüm hasta grubunun her dört ölçüm değeri de kontrol grubuna göre anlamlı derecede yüksekti (sırasıyla; p0,013, p0,009, p0,011 ve p0,015). Tüm hasta grubu alt gruplarına ayrılarak karşılaştırıldığında ise; sadece Wilms tümörü grubunun, ilk ölçüm değeri, kontrol grubuna göre anlamlı derecede yüksekti (p0,026). Sonuç: Daha geniş hasta gruplarının katılımıyla yapılacak çalışmalara ihtiyaç olmakla beraber tenascin-C, Wilms tümörü grubunda olduğu gibi, bazı spesifik tümörlerin ayırıcı tanısında yol gösterici olabilir
Objective: The aim of this study was to evaluate the significance of serum tenascin-C levels in the diagnosis, treatment, and monitoring of small round blue cell tumors. Materials and methods: Forty patients and 30 healthy children (control group) were included in this prospective study. Serum tenascin-C levels were measured from blood drawn at the time of diagnosis, at the 3rd and 6th months of treatment, and at 3 months following the completion of treatment. While serum tenascin-C levels were measured a total of 4 times in the patient group, they were measured just once in the control group. Results: Each of the four measured serum tenascin-C levels in the patient group was significantly higher than that of the control group (p0,013, p0,009, p0,011 and p0,015, respectively). However, when the patient group was categorized into subgroups, only those with Wilms tumor had a significantly higher serum tenascin-C level at the time of diagnosis than did the control group (p0,026). Conclusion: While larger, more thorough studies are needed, our data suggest that tenascin-C may be useful in the differential diagnosis of certain specific tumors, such as the Wilms tumor
Objective: The aim of this study was to evaluate the significance of serum tenascin-C levels in the diagnosis, treatment, and monitoring of small round blue cell tumors. Materials and methods: Forty patients and 30 healthy children (control group) were included in this prospective study. Serum tenascin-C levels were measured from blood drawn at the time of diagnosis, at the 3rd and 6th months of treatment, and at 3 months following the completion of treatment. While serum tenascin-C levels were measured a total of 4 times in the patient group, they were measured just once in the control group. Results: Each of the four measured serum tenascin-C levels in the patient group was significantly higher than that of the control group (p0,013, p0,009, p0,011 and p0,015, respectively). However, when the patient group was categorized into subgroups, only those with Wilms tumor had a significantly higher serum tenascin-C level at the time of diagnosis than did the control group (p0,026). Conclusion: While larger, more thorough studies are needed, our data suggest that tenascin-C may be useful in the differential diagnosis of certain specific tumors, such as the Wilms tumor
Açıklama
Anahtar Kelimeler
Cerrahi
Kaynak
Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
22
Sayı
3
