Sigara Dumanına Maruz Kalan Sıçanlarda Aortanın Histopatolojik Değişiklikleri ve Element Içerikleri
Küçük Resim Yok
Tarih
1998
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Sigara dumanının sıçan aortalarında oluşturduğu histopatolojik değişiklikleri ve element içeriğini araştırmak için deney grubu hayvanlara 90 gün boyunca, günde bir saat 1/9 oranında sigara dumanı/hava solutuldu. Bu sırada kontrol grubundaki sıçanlara da oda havası solutuldu. Solutma işleminin sonunda aortalar histopatolojik olarak incelendi. Element içeriği atomik absorbsiyon spektrofotometresi ile ölçüldü. Histopatolojik olarak kontrol .grubu aortalannda herhangi bir patoloji gözlenilmedi. Sigara solutulan sıçanların aortalannda ise grade I ve U düzeyinde aterosklerotik bulgular saptanıldı. Sigara solutulan hayvanların aortalannda, kontrol grubuna göre demir ve kalsiyum düzeyleri anlamlı derecede yüksek bulunurken (p0.05), magnezyum içe-riği ise düşük bulundu (p0.05). Arter duvan demir ve kalsiyum içeriğindeki artış ile birlikte magnezyum içeriğindeki azalmanın lipidperoksidasyonu artırarak aterogenezi hızlandırabileceği düşünüldü.
To investigate possible histopathological damage and changes in trace element concentrations in aorta following cigarette smoke exposure, we exposed experimental group of rats to 10% concentration of cigarette smo-ke 1 hour each day for 90 consecutive days. Shamexposed control rats were inhaled roomair under similar condition. At the end of the experiment, specimens prepared from aorta were examined histopathologically. The iron, calcium and magnesium contents of aorta were determined by using atomic absorption spectrophoto-metty technique. Although there was no pathological finding in sham exposed control group, grade I to II atherosclerotic degeneration was observed in all smoke-exposed animals. The iron and calcium contents of aorta were found to be significantly higher in smoke exposed rats than those of the sham exposed control (p<0:05). Magnesium contents of aorta were lower in experimental group compared to the control animals (p<0.05). It is suggested that, enhanced iron and calcium together with decreased magnesium content of artery wall following smoke exposure can promote atherogenesis by increasing lipid peroxidation.
To investigate possible histopathological damage and changes in trace element concentrations in aorta following cigarette smoke exposure, we exposed experimental group of rats to 10% concentration of cigarette smo-ke 1 hour each day for 90 consecutive days. Shamexposed control rats were inhaled roomair under similar condition. At the end of the experiment, specimens prepared from aorta were examined histopathologically. The iron, calcium and magnesium contents of aorta were determined by using atomic absorption spectrophoto-metty technique. Although there was no pathological finding in sham exposed control group, grade I to II atherosclerotic degeneration was observed in all smoke-exposed animals. The iron and calcium contents of aorta were found to be significantly higher in smoke exposed rats than those of the sham exposed control (p<0:05). Magnesium contents of aorta were lower in experimental group compared to the control animals (p<0.05). It is suggested that, enhanced iron and calcium together with decreased magnesium content of artery wall following smoke exposure can promote atherogenesis by increasing lipid peroxidation.
Açıklama
Anahtar Kelimeler
Genel ve Dahili Tıp
Kaynak
Türkiye Tıp Dergisi Dahili Tıp Bilimleri
WoS Q Değeri
Scopus Q Değeri
Cilt
5
Sayı
6
Künye
Avunduk, M. C., Yardımcı, S., Sungurluoğlu, K., Kurnaz, L., Koçkar, C., Delibaşı, T., (1998). Sigara Dumanına Maruz Kalan Sıçanlarda Aortanın Histopatolojik Değişiklikleri ve Element Içerikleri, Türkiye Tıp Dergisi Dahili Tıp Bilimleri, 5(6), 388-392.
