Reduced CD19 Expression and Decreased Memory B Cell Numbers in Transient Hypogammaglobulinemia of Infancy

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dc.contributor.authorArtaç, Hasibe
dc.contributor.authorGöktürk, Bahar
dc.contributor.authorKara, Reyhan
dc.contributor.authorReisli, İsmail
dc.date.accessioned2020-03-26T17:47:22Z
dc.date.available2020-03-26T17:47:22Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description29th Congress of the European-Academy-of-Allergy-and-Clinical-Immunology (EAACI) -- JUN 05-09, 2010 -- London, ENGLANDen_US
dc.description.abstractWe aimed to evaluate the role of the CD19 complex in the pathogenesis of transient hypogammaglobulinemia of infancy (THI) and to better characterize the subsets of memory B cells. The study population consisted of 22 male and 14 female patients with a mean age at presentation of 20 ± 9.9 months. The CD19 complex and B cell subsets were evaluated by flow cytometry. While the CD19 median fluorescence index (MFI) in patients with THI was significantly lower than controls (122.9 ± 66.7 in patients; 184.2 ± 39 in controls, p\0.01), expression of CD21 and CD81 was increased (94.4 ± 3, 96.8 ± 2.5 % in patients; 91 ± 3.9; 94.7 ± 3.5 % in controls, p\0.01 vs. p\0.05, respectively). The expressions of switched memory B cells and IgM memory B cells were found to be reduced in THI. Considering that the CD19 complex regulates the events following antigen stimulation, the change in CD19 complex detected in THI may be related to insufficiency of antibody production.en_US
dc.description.sponsorshipEuropean Acad Allergy and Clin Immunolen_US
dc.identifier.citationArtaç, H., Göktürk, B., Kara, R., Reisli, İ., (2012). Reduced CD19 Expression and Decreased Memory B Cell Numbers in Transient Hypogammaglobulinemia of Infancy. Allergy, (65), 642-648. Doi: 10.1007/s10238-012-0200-y
dc.identifier.endpage648en_US
dc.identifier.issn0105-4538en_US
dc.identifier.issn1398-9995en_US
dc.identifier.startpage642en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/24682
dc.identifier.volume65en_US
dc.identifier.wosWOS:000329462103314en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.institutionauthorArtaç, Hasibe
dc.institutionauthorKara, Reyhan
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofAllergyen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectTransient hypogammaglobulinemia
dc.subjectCd19 complex
dc.subjectMemory b cells
dc.titleReduced CD19 Expression and Decreased Memory B Cell Numbers in Transient Hypogammaglobulinemia of Infancyen_US
dc.typeConference Objecten_US

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