Squamous Cell Carcinomalı Hastalarda Normal ve Tümöral Dokudaki Zn ve Fe Seviyelerinin Karşılaştırılması
Küçük Resim Yok
Tarih
2000
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Eser elementlerin enzimatik reaksiyonları inhi-be veya aktive ederek bir dizi biyolojik olayda rol oynadığı çok iyi bilinmektedir. Ancak malign hastalıklar veya teşhis ve prognozdaki klinik önemleri hala tartışmalıdır ve baş-boyun tümörleri üzerindeki etkileri tam olarak bilinmemektedir. Bu çalışma, %53'ü üçüncü evrede % 40 ise ikinci evrede olan 15 Squamous cell carcinomalı (SCC) hastada planlandı. Çinko ve demir seviyesinin belirlenmesi için hem tümör hem-de sağlıklı doku örnekleri SCC hastalardan elde edildi. Bu elementlerin seviyesi atomik ab-sorpsiyon spektrofotometre kullanarak belirlendi. Tumoral dokudaki çinko ve demir seviyeleri kontrol grubundaki çinko ve demir seviyeleri ile karşılaştırıldığında, her iki elementin seviyesinin tümör dokusunda kontrol grubundan yaklaşık 2 kat kadar fazla olduğu görüldü. Tümör dokusunda ortalama çinko ve demir seviyesi 141,8866,93 ug/g ve 868,76 461,92 ug/g olarak bulundu. Sağlıklı dokuda çinko 65,0324,24ug/g ve 430,84211,37 ug/g idi. Bu fark istatistiksel olarak anlamlı bulundu (p0.05). Tümör dokusundaki çinko ve demir seviyesi ile tümör evresi arasında anlamlı bir ilişki bulundu (p0.05). Bu çalışmadan elde edilen veriler, aşın çinko ve demir elementlerin seviyesinin baş-boyun SCC'lı hastaların karsinogenezisi üzerinde etkili olabileceğini göstermektedir.
It is well known that trace elements play a ro¬le in a number of biologic processes through their action as activators or inhibitors of enzy¬matic reactions. However, it is still discussed about their clinical significance in diagnosis and prognosis of malignant diseases and their effects on head and neck tumors has not been exactly understood, yet. This study was planned on 15 patients with squamous cell carsinoma (SCC) and 53% of the patients was in disease stage III and 40% in stage II. Both tumoral and healthy tissue specimens were obtained from SCC patients to determine zinc and iron levels. These ele¬ments were determined by using atomic ab¬sorption spectrophotometry. The zinc and iron levels in tumoral tissues were approxima¬tely two times greater than healthy specimens. The mean zinc and iron levels were found as 141.88±66.93 ug/g and 868.76±461 ug/g in tumoral tissues, 65.03±24.24ug/g and 430.84±211.37 ug/g in healthy tissues, res¬pectively. The differences were statistically sig¬nificant (p<0.05). Additionally, there was a significant correlation between tissue levels of these elements and tumor stage (p<0.05). Data obtained from this study suggest that ex¬cessive zinc and iron levels may be effective on carsinogenesis of the head and neck SCC.
It is well known that trace elements play a ro¬le in a number of biologic processes through their action as activators or inhibitors of enzy¬matic reactions. However, it is still discussed about their clinical significance in diagnosis and prognosis of malignant diseases and their effects on head and neck tumors has not been exactly understood, yet. This study was planned on 15 patients with squamous cell carsinoma (SCC) and 53% of the patients was in disease stage III and 40% in stage II. Both tumoral and healthy tissue specimens were obtained from SCC patients to determine zinc and iron levels. These ele¬ments were determined by using atomic ab¬sorption spectrophotometry. The zinc and iron levels in tumoral tissues were approxima¬tely two times greater than healthy specimens. The mean zinc and iron levels were found as 141.88±66.93 ug/g and 868.76±461 ug/g in tumoral tissues, 65.03±24.24ug/g and 430.84±211.37 ug/g in healthy tissues, res¬pectively. The differences were statistically sig¬nificant (p<0.05). Additionally, there was a significant correlation between tissue levels of these elements and tumor stage (p<0.05). Data obtained from this study suggest that ex¬cessive zinc and iron levels may be effective on carsinogenesis of the head and neck SCC.
Açıklama
Anahtar Kelimeler
Diş Hekimliği
Kaynak
Hacettepe Dişhekimliği Fakültesi Derg.(. Clinical Dentistry and Research)
WoS Q Değeri
Scopus Q Değeri
Cilt
24
Sayı
03.Apr
Künye
Uçkan, S., Öztürk, K., Güler, N., Ataoğlu, H., (2000). Squamous Cell Carcinomalı Hastalarda Normal ve Tümöral Dokudaki Zn ve Fe Seviyelerinin Karşılaştırılması. Hacettepe Dişhekimliği Fakültesi Derg.(. Clinical Dentistry and Research), 24(03.Apr), 39-43.
