Üriner Sistem Kalsiyum Taş Hastalığına Bağlı Kemik Kütlesi Değişiklikleri
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Dosyalar
Tarih
2008
Dergi Başlığı
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Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Üriner sistem taş hastalığı ülkemizde sık görülen bir patolojidir. Kalsiyum taşları bu hastalık grubunun en büyük kısmını oluşturur. Hiperkalsiüri, taş hastalarında en sık görülen metabolik bozukluktur ve bu hastalarda kalsiyum metabolizması bozularak kemik kütlesini etkileyebilmektedir. Bu çalışmada kalsiyum taş hastalığı bulunan hastalardaki kemikler kütlesindeki değişikliklerin araştırılması amaçlandı. Yöntem: Çalışmaya kalsiyum taş hastalığı tanısı ile takip edilen yaşları 20-50 arasında değişen (ortalama yaş 39.8) 41 erkek olgu alındı. Taş hastalığı hikayesi bulunmayan 20-50 yaşları arasında değişen (ortalama yaş 39.9) 40 erkek olgu ise kontrol grubu olarak alındı. Her iki grubun kemik kütle ölçümleri femur boynu ve lumbal vertebra düzeyinde dual-enerji-x-ray absorpsiyometri yöntemi ile yapıldı. Olgulara diyet kısıtlanması yapılmadan 24 saatlik idrar metabolik değerlendirmesi, kan biyokimyası testleri yapıldı. Bulgular: Çalışma grubu ile kontrol grubunun yaş dağılımları ve vücut kütle indeksleri arasında anlamlı fark saptanmadı (P0.097). Taş hastalığı bulunan olgulardan 20’si (% 48) hiperkalsiürik idi. Kemik mineral dansiteleri çalışma grubundaki 17 olguda (% 41), kontrol grubunda ise yalnızca bir olguda (% 2.5) düşük idi, gruplar arasında anlamlı fark vardı (P0.05). Osteoporoz ve osteopeni oranları çalışma grubunda kontrol grubuna göre fazla bulundu (P0.001, P0.001). Osteoporoz ile rekürrens arasında anlamlı ilişki bulundu (r0717, P0.01). Sonuç: Taş hastalığı osteoporoz için bir risk faktörüdür. Özellikle rekürren olgularda kemik kütlesi değerlendirilmeli, koruyucu önlemler alınmalı ve hastalar bilgilendirilmelidir.
Objective: Urinary stone disease is a common pathology in our country. Calcium nephrolithiasis is the most frequently observed type among these patients. Hypercalciuria is the most common metabolic disorder and the bone mass might be altered with the disturbed calcium metabolism in these patients. In this study the bone mass alterations in patients with calcium stone disease was aimed. Methods: 41 male patient with calcium stone disease, aged between 20-50 (mean age 39.76) were studied, and 40 males without stone disease aged between 20-50 (mean age 39.85) formed the control group. The bone mass evaluation was performed with the Dual-Energy-X ray Absorptiometry on the level of femur neck and the lumbar region. Blood biochemistry and 24 hour urinary samples were evaluated without and diet restriction. Results: There were no difference in comparison of the age and the body mass index between the study group and the control group (P=0967). In the study group 20 patients (48%) were hypercalciuric. The bone mineral density was below the normal ranges in 17 patients (41%) in study group, but only one (2.5 %) in the control group, it was statistically significant (P<0.05). Osteoporosis and osteopenia was significantly higher in the study group (P<0.001, P<0.001). There was correlation between osteoporosis and recurrence (r=0.717, P<0.01). Conclusion: Stone disease is a risk for osteoporosis. The bone mass should be evaluated in especially in recurrent cases, and the patients, precautions regarding protection of the bone mass should be taken and the patient should be informed.
Objective: Urinary stone disease is a common pathology in our country. Calcium nephrolithiasis is the most frequently observed type among these patients. Hypercalciuria is the most common metabolic disorder and the bone mass might be altered with the disturbed calcium metabolism in these patients. In this study the bone mass alterations in patients with calcium stone disease was aimed. Methods: 41 male patient with calcium stone disease, aged between 20-50 (mean age 39.76) were studied, and 40 males without stone disease aged between 20-50 (mean age 39.85) formed the control group. The bone mass evaluation was performed with the Dual-Energy-X ray Absorptiometry on the level of femur neck and the lumbar region. Blood biochemistry and 24 hour urinary samples were evaluated without and diet restriction. Results: There were no difference in comparison of the age and the body mass index between the study group and the control group (P=0967). In the study group 20 patients (48%) were hypercalciuric. The bone mineral density was below the normal ranges in 17 patients (41%) in study group, but only one (2.5 %) in the control group, it was statistically significant (P<0.05). Osteoporosis and osteopenia was significantly higher in the study group (P<0.001, P<0.001). There was correlation between osteoporosis and recurrence (r=0.717, P<0.01). Conclusion: Stone disease is a risk for osteoporosis. The bone mass should be evaluated in especially in recurrent cases, and the patients, precautions regarding protection of the bone mass should be taken and the patient should be informed.
Açıklama
Anahtar Kelimeler
Genel ve Dahili Tıp, Kalsiyum taş hastalığı, osteoporoz, kemik mineral dansitesi, Calcium stone disease, osteoporosis, bone mineral density
Kaynak
Genel Tıp Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
18
Sayı
1
Künye
Pişkin, M. M., Karalezli, G., Kılınç, M., (2008). Üriner Sistem Kalsiyum Taş Hastalığına Bağlı Kemik Kütlesi Değişiklikleri. Genel Tıp Dergisi, 18(1), 27-31.
