Psödoeksfoliasyon Sendromlu ve SenilKataraktlı Gözlerin Ön Segment Biyometri veKornea Endotel Özellikleri
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Tarih
2015
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Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Psödoeksfoliasyon (PE) sendromu ve senil kataraktı olan gözlerin ön segment biyometrik özelliklerinin ve kornea endotel değişikliklerinin değerlendirilmesi.Gereç ve Yöntem: PE sendromlu 52 hastanın optikal düşük-koherens reflektometre (ODKR, Lenstar LS 900; Haag Streit AG, İsviçre) ile alınan merkezi kornea kalınlığı, ön kamara derinliği (ÖKD), pupil çapı, lens kalınlığı ile in-vivo konfokal mikroskop (ConfoScan4, Nidek Co. Ltd., Osaka, Japonya) ile ölçülen endotel hücre dansitesi (EHD), polimegatizm (%) ve pleomorfizm (%) parametreleri yaş ve cinsiyet uyumlu PE sendromu olmayan 51 kataraktlı bireyle karşılaştırıldı. PE sendromu olan hastaların 19'unda glokom mevcuttu ve topikal anti-glokom tedavisi alıyorlardı. Çalışmaya katılan bireylerin sadece tek gözü istatistik analiz için kullanıldı ve p0.05 istatistiksel olarak anlamlı kabul edildi. Bulgular: ODKR parametrelerinin hiçbiri gruplar arasında istatistiksel olarak anlamlı farklılık göstermemekteydi (ANOVA p0,05). Kontrol grubunun %13,7'sinde, glokomu olmayan PE grubunun %24,2'sinde ve glokomu olan PE'li olguların %21,1'inde ÖKD 2,5 mm altındaydı (p0,45). Ortalama EHD 3 grup arasında istatistiksel olarak anlamlı farklılık göstermekteyken (ANOVA p0,02), polimegatizm ve pleomorfizm açısından farklılık izlenmedi (p0,05). Ortalama EHD, PE glokomlu gözlerde (2199,5176,8 hücre/mm2) kontrol grubuna göre daha düşüktü (2363229,3 hücre/mm2) (p0,02), fakat glokomu olmayan PE'li gözlerin EHD değerleri ile kontrol grubu arasında farklılık yoktu (p0,42). PE glokomlu gözlerin %15,8'inde, kontrol grubunun %9,8'inde, glokomu olmayan PE'li gözlerin %6,1'inde EHD 2000 hücre/mm2 altında bulundu (p0,52). Sonuç: PE glokomu ve kataraktı olan gözlerde endotel hücre sayısı daha düşük olabileceği için intraoküler cerrahi planlanan hastaların speküler veya konfokal mikroskopi ile değerlendirilmesi gerekmektedir.
Objectives: To evaluate the anterior segment biometric features and corneal endothelial changes in eyes with Pseudoexfoliation (PEX) syndrome and senile cataract.Materials and Methods: The central corneal thickness, anterior chamber depth (ACD), pupil diameter, lens thickness, endothelial cell density (ECD), and percentages of polymegathism and pleomorphism of 52 subjects with PEX and cataract were compared with 51 age- and gender-matched control subjects with cataract using optical low-coherence reflectometry (OLCR, Lenstar LS 900; Haag Streit AG, Switzerland) and in-vivo confocal microscopy (Confo Scan 4, Nidek Co. Ltd, Osaka, Japan). Nineteen subjects with PEX syndrome had glaucoma and were using anti-glaucoma medications. Only one eye of the subjects was used in statistical analysis and a p value less than 0.05 was considered statistically significant. Results: None of the OLCR parameters reached statistically significant differences among the 3 groups (ANOVA p>0.05). The percentage of eyes with ACD <2.5 mm was 13.7% in the control group, 24.2% in PEX eyes without glaucoma and 21.1% in PEX eyes with glaucoma, with no statistically significant differences (p0.45). There was a significant difference in mean ECD among the 3 groups (ANOVA p0.02), whereas no differences could be found in respect to polymegathism and pleomorphism (p>0.05). Mean ECD was significantly lower in the PEX glaucoma group (2,199.5±176.8 cells/mm2) than the control group (2,363±229,3 cells/mm2) (p0.02), whereas no difference was found in mean ECD of PEX eyes without glaucoma and the control group (p0.42). ECD was less than 2,000 cells/mm2 in 15.8% of PEX subjects with glaucoma, 9.8% of control subjects and 6.1% of PEX eyes without glaucoma, with no statistically significant difference (p0.52). Conclusion: As eyes with both PEX glaucoma and cataract seem to be associated with decreased endothelial cell number, specular or confocal microscopy screening should be done for the patients scheduled for intraocular surgery.
Objectives: To evaluate the anterior segment biometric features and corneal endothelial changes in eyes with Pseudoexfoliation (PEX) syndrome and senile cataract.Materials and Methods: The central corneal thickness, anterior chamber depth (ACD), pupil diameter, lens thickness, endothelial cell density (ECD), and percentages of polymegathism and pleomorphism of 52 subjects with PEX and cataract were compared with 51 age- and gender-matched control subjects with cataract using optical low-coherence reflectometry (OLCR, Lenstar LS 900; Haag Streit AG, Switzerland) and in-vivo confocal microscopy (Confo Scan 4, Nidek Co. Ltd, Osaka, Japan). Nineteen subjects with PEX syndrome had glaucoma and were using anti-glaucoma medications. Only one eye of the subjects was used in statistical analysis and a p value less than 0.05 was considered statistically significant. Results: None of the OLCR parameters reached statistically significant differences among the 3 groups (ANOVA p>0.05). The percentage of eyes with ACD <2.5 mm was 13.7% in the control group, 24.2% in PEX eyes without glaucoma and 21.1% in PEX eyes with glaucoma, with no statistically significant differences (p0.45). There was a significant difference in mean ECD among the 3 groups (ANOVA p0.02), whereas no differences could be found in respect to polymegathism and pleomorphism (p>0.05). Mean ECD was significantly lower in the PEX glaucoma group (2,199.5±176.8 cells/mm2) than the control group (2,363±229,3 cells/mm2) (p0.02), whereas no difference was found in mean ECD of PEX eyes without glaucoma and the control group (p0.42). ECD was less than 2,000 cells/mm2 in 15.8% of PEX subjects with glaucoma, 9.8% of control subjects and 6.1% of PEX eyes without glaucoma, with no statistically significant difference (p0.52). Conclusion: As eyes with both PEX glaucoma and cataract seem to be associated with decreased endothelial cell number, specular or confocal microscopy screening should be done for the patients scheduled for intraocular surgery.
Açıklama
Anahtar Kelimeler
Göz Hastalıkları
Kaynak
Türk Oftalmoloji Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
45
Sayı
5
