The Effects of Ticlopidine in Acute Myocardial Infarction as an Adjunctive Treatment to Aspirin in an Intermediate Term Setting

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dc.contributor.authorCin, Gökhan Veli
dc.contributor.authorTemizhan, Ahmet
dc.contributor.authorPekdemir, Hasan
dc.contributor.authorTokaç, Mehmet
dc.contributor.authorTartanoğlu, Okan
dc.date.accessioned2020-03-26T16:45:03Z
dc.date.available2020-03-26T16:45:03Z
dc.date.issued2002
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAntiplatelet therapy reduces the risk of subsequent ischemic events in patients suffering from acute myocardial infarction (AMI). In this respect, the multi-agent therapy to be used along with aspirin remains to be determined. In this study, ticlopidine was tried in AMI for its potential additive effects over aspirin. Ninety patients with similar clinical characteristics were involved and were followed up for 3 and 6 months. All patients were assigned to receive ticlopidine plus aspirin or aspirin alone. Major cardiac events such as death and reinfarction were primary end-points whereas the need for revascularization was the secondary end-point at 3 and 6 months. Although no variable was significantly different, it was noteworthy that the ticlopidine group showed less need for revascularization (mainly coronary bypass surgery at 3 and 6 months (15.9% vs. 30.4%, 20.5% vs. 30.4%) and reinfarction rates (4.5% vs. 10.9% and 6.8% vs. 13%). This study was one of the few to evaluate the effects of adjunctive ticlopidine treatment in AMI. Despite the lack of significant superiority over aspirin alone, the additional effects of ticlopidine could be a reduction in reinfarction rates and the need for bypass surgery at 3-and 6-months if more patients were involved. Nevertheless, comprehensive, large-scale studies are essential to disclose the net effect.en_US
dc.identifier.citationCin, G. V., Temizhan, A., Pekdemir, H., Tokaç, M., Tartanoğlu, O., (2002). The Effects of Ticlopidine in Acute Myocardial Infarction as an Adjunctive Treatment to Aspirin in an Intermediate Term Setting. Turkish Journal of Medical Sciences, 32(4), 329-334.
dc.identifier.endpage334en_US
dc.identifier.issn1300-0144en_US
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage329en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/18179
dc.identifier.volume32en_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorTemizhan, Ahmet
dc.institutionauthorTokaç, Mehmet
dc.institutionauthorTartanoğlu, Okan
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAcute myocardial infarctionen_US
dc.subjectAspirinen_US
dc.subjectTiclopidineen_US
dc.titleThe Effects of Ticlopidine in Acute Myocardial Infarction as an Adjunctive Treatment to Aspirin in an Intermediate Term Settingen_US
dc.typeArticleen_US

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