Sübstitüe taç eter ihtiva eden kitosanların sentezi
Yükleniyor...
Dosyalar
Tarih
2006
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Selçuk Üniversitesi Fen Bilimleri Enstitüsü
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Kitin, kabuklu deniz ürünlerinin kabuklarında bol bulunan doğal bir polisakkarittir. Selülozdan sonra doğada en bol bulunan biyopolimerdir. Kimyasal olarak kitin poli[β-(1â 4)-N-asetil-D-glukozamin]'dir. Kitosan ise kitinin alkali deasetilasyonu ile hazırlanır ve yapısı poli[β-(1â 4)-D-glukozamin]'dir. Kitosanın tarımda tohum kaplaması ve dondan koruma, su arıtımında koku giderici, gıdada anti-kolestrol katkı maddesi gibi birçok kullanımı bulunmaktadır. Dolayısıyla bu çalışmanın amacı yeni kitosan türevleri hazırlamaktır. Öncelikle, farklı halka büyüklüğü olan aza-taç eterler Williamson tipi eter sentezi ile elde edildi. Bu ligandların fenil grupları Vilsmeier-Haack formilasyonu ile fonksiyonlandırıldı. Yapıları IR ve 1H NMR spektroskopileri ve elementel analiz ile karakterize edildi. Kitosan ile aza-taç eterlerin Schiff baz reaksiyonundan N-Schiff baz tipi kitosan aza-taç eterleri hazırlandı. Elde edilen kitosan türevleri NaBH4 ile indirgenerek N-sekonder amino tipi kitosan aza-taç eterleri hazırlandı. Yeni kitosan türevlerinin yapıları IR spektroskopisi ve elementel analiz ile aydınlatıldı.
Chitin is a natural polysaccharide found in abundance in the shell of crustaceans. After cellulose, chitin is the most abundant natural biopolymer found in nature. Chemically, chitin is poly[β-(1â 4)-N-acetyl-D-glucosamine]. Chitosan is prepared from chitin by alkaline deactylation and its structure is poly[β-(1â 4)-D- glucosamine]. Chitosan have found many uses such as seed-coating and frost protection in agriculture, odor remover for water treatment, anti-cholesterol additives in food. Therefore, the aim of this study is to prepare novel chitosan derivates. Firstly, aza-crown ethers of different ring size were synthesized using Williamson type ether synthesis. Phenyl groups of these ligands were formylated by Vilsmeier-Haack formylation. Structures of them were characterized by IR and 1H NMR spectroscopies, and elemental analysis. N-Schiff base type chitosan aza-crown ethers were prepared from the reaction chitosan with aza-crown ethers. The obtained- chitosan derivatives were reduced to N-secondary amino type chitosan aza-crown ethers with NaBH4. Structures of novel chitosan derivatives were confirmed by IR spectroscopy and elemental analysis.
Chitin is a natural polysaccharide found in abundance in the shell of crustaceans. After cellulose, chitin is the most abundant natural biopolymer found in nature. Chemically, chitin is poly[β-(1â 4)-N-acetyl-D-glucosamine]. Chitosan is prepared from chitin by alkaline deactylation and its structure is poly[β-(1â 4)-D- glucosamine]. Chitosan have found many uses such as seed-coating and frost protection in agriculture, odor remover for water treatment, anti-cholesterol additives in food. Therefore, the aim of this study is to prepare novel chitosan derivates. Firstly, aza-crown ethers of different ring size were synthesized using Williamson type ether synthesis. Phenyl groups of these ligands were formylated by Vilsmeier-Haack formylation. Structures of them were characterized by IR and 1H NMR spectroscopies, and elemental analysis. N-Schiff base type chitosan aza-crown ethers were prepared from the reaction chitosan with aza-crown ethers. The obtained- chitosan derivatives were reduced to N-secondary amino type chitosan aza-crown ethers with NaBH4. Structures of novel chitosan derivatives were confirmed by IR spectroscopy and elemental analysis.
Açıklama
Anahtar Kelimeler
Kitin, Chitin, Kitosan, Chitosan, Aza-taç eter, Aza-crown ether, Schiff bazı, Schiff base
Kaynak
WoS Q Değeri
Scopus Q Değeri
Cilt
Sayı
Künye
Malkondu, S. (2006). Sübstitüe taç eter ihtiva eden kitosanların sentezi. Selçuk Üniversitesi, Yayımlanmış yüksek lisans tezi, Konya.
