Does hypericin boost the efficacy of high-power laser? A preliminary experimental study on rats [A hipericina aumenta a eficácia do laser de alta potência? um estudo preliminar e experimental em ratos]
Küçük Resim Yok
Tarih
2014
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Associacao Paulista de Medicina
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
DESIGN AND SETTING: Experimental animal study conducted in the Department of Urology, Gülhane Military Medical Academy, Ankara, Turkey, in 2012.METHODS: Sixteen rats were randomized into four groups: 120 W KTP laser + hypericin; 120 W KTP laser alone; 80 W KTP laser + hypericin; and 80 W KTP laser alone. Hypericin was given intraperitoneally two hours prior to laser applications. The laser incisions were made through the quadriceps muscle of the rats. The depth and the width of the laser incisions were evaluated histologically and recorded.RESULTS: To standardize the effects of the laser, we used the ratio of depth to width. These new values showed us the depth of the laser application per unit width. The new values acquired were evaluated statistically. Mean depth/width values were 231.6, 173.6, 214.1 and 178.9 in groups 1, 2, 3 and 4, respectively. The most notable result was that higher degrees of tissue penetration were achieved in the groups with hypericin (P < 0.05).CONCLUSIONS: The encouraging results from our preliminary study demonstrated that hypericin may improve the effects of KTP laser applications.CONTEXT AND OBJECTIVE: Lasers are widely used in treating symptomatic benign prostatic hyperplasia. In current practice, potassium titanyl phosphate (KTP) lasers are the most common type of laser systems used. The aim here was to evaluate the rapid effect of high-power laser systems after application of hypericin. © 2014 Associacao Paulista de Medicina. All right reserved.
Açıklama
Anahtar Kelimeler
Endoscopy, Hypericum, Lasers, solid-state, Photochemotherapy, Prostatic hyperplasia
Kaynak
Sao Paulo Medical Journal
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
132
Sayı
6
