Measuring Temperature Change at the Nanometer Scale on Gold Nanoparticles by Using Thermoresponsive PEGMA Polymers

Basit Öğe Kaydı
dc.contributor.authorYavuz, Mustafa S.
dc.contributor.authorCitir, Murat
dc.contributor.authorCavusoglu, Halit
dc.contributor.authorDemirel, Gokhan
dc.date.accessioned2020-03-26T19:42:03Z
dc.date.available2020-03-26T19:42:03Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractPlasmonic heating of gold nanoparticles (AuNPs) under laser illumination is a highly desirable technique, especially for cancer therapy. However, significant drawbacks still remain including uncontrolled heat release from AuNPs, random exposure duration, and selection of the proper laser power without damaging normal healthy cells. Herein, we demonstrate a simple and versatile method to measure temperature variation on the surface of Au nanoparticles under laser irradiation based on a thermoresponsive polymer, poly(ethylene glycol) methylether methacrylate (PEGMA). In this context, a series of PEGMA polymers were synthesized to have different lower critical solution temperature (LCST) values (28-90 degrees C) and conjugated to the surface of spherical AuNPs by a gold-thiolate linkage. According to our strategy, the AuNPs first photothermally absorb light energy and convert it to heat owing to their tailored photothermal characteristics. The generated heat from the AuNPs subsequently dissipates into the surrounding thermoresponsive PEGMA polymer. When the temperature generated on the Au surface upon laser irradiation for a certain exposure time reaches the LCST value of the surrounding PEGMA polymer, the polymer chain collapses. Therefore, the hydrodynamic diameter of the PEGMA-coated AuNPs changes, which can be easily monitored by using dynamic light scattering (DLS). We systematically measured the temperature (28-90 degrees C) generated on the AuNP surfaces by using different laser power densities with varying durations. We believe that the resulting strategy will be very valuable for oncologists to easily predict the minimum laser power and duration needed to destroy the cancer cells through the photothermal effect of Au nanostructures.en_US
dc.description.sponsorshipResearch Foundation of the Selcuk UniversitySelcuk University; Abdullah Gul University [FOA-2015-9]; TUBITAKTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [112M096, COST TD1004, COST MP1302]; Turkish Academy of Sciences Distinguished Young Scientist Award (TUBA-GEBIP)Turkish Academy of Sciencesen_US
dc.description.sponsorshipThis work was supported by the Research Foundation of the Selcuk University (BAP), Abdullah Gul University (BAP) (Project No: FOA-2015-9), and TUBITAK (Project No. 112M096, COST TD1004, COST MP1302). Gokhan Demirel acknowledges support from the Turkish Academy of Sciences Distinguished Young Scientist Award (TUBA-GEBIP).en_US
dc.identifier.doi10.1002/cnma.201700081en_US
dc.identifier.endpage502en_US
dc.identifier.issn2199-692Xen_US
dc.identifier.issue7en_US
dc.identifier.startpage496en_US
dc.identifier.urihttps://dx.doi.org/10.1002/cnma.201700081
dc.identifier.urihttps://hdl.handle.net/20.500.12395/35281
dc.identifier.volume3en_US
dc.identifier.wosWOS:000405241900008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherWILEY-V C H VERLAG GMBHen_US
dc.relation.ispartofCHEMNANOMATen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectgold nanoparticlesen_US
dc.subjectlower critical solution temperatureen_US
dc.subjectpoly(ethylene glycol) methylether methacrylateen_US
dc.subjectphotothermalen_US
dc.subjectthermometersen_US
dc.subjectthermoresponsive polymersen_US
dc.titleMeasuring Temperature Change at the Nanometer Scale on Gold Nanoparticles by Using Thermoresponsive PEGMA Polymersen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu