Can flow-cytometry be used at diagnosis and follow-up in neuroblastoma with bone marrow involvement?
Küçük Resim Yok
Tarih
2006
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
A 4.5-year-old boy was admitted to our clinic with fever, which had persisted for one month, weakness, and hand, arm and knee pain. Physical examination was remarkable for pallor, the movement of the right knee was painful and restricted, yet both knees were same in diameter. The peripheral blood smear revealed moderate immature lymphocytosis. Bone marrow aspiration revealed uniform cells with narrow cytoplasm and hyperchromatic nuclei which formed a "rosette" scene. On bone marrow flow-cytometry examination, CD45(-)/CD44(+)/CD56(+) cells were 70% positive. The urinary VMA level was 41.6 mg/24 h. There was an anterior paramediastinal mass and vertebral destructions in thoracal computed tomography (CT). Cranial CT and magnetic resonance imaging (MRI) revealed duramater involvement and numerous subdural tumors. A paravertebral mass that extended into the spinal canal was determined with spinal MRI. Stage IV neuroblastoma (NB) was diagnosed and ENSG-3C chemotherapy protocols including cisplatin, etoposide, ifosfamide, mesna, vincristine and adriamycine was given. After two cycle of the chemotherapy, bone marrow aspiration was normal and CD45(-)/CD44(+)/CD56(+) cells were 5% positive. Following treatment, he has been in remission for 18 months. Flow-cytometry may be useful for the diagnosis and follow-up of NB with bone marrow involvement.
Açıklama
Anahtar Kelimeler
Anterior mediastinum, Children, Duramater, Flow-cytometry, Neuroblastoma
Kaynak
Turkish Journal of Cancer
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
36
Sayı
1
