Dosetaksel tedavisi ile ilişkili El Ayak Sendromu gelişen metastatik prostat kanserli bir hasta
Küçük Resim Yok
Tarih
2017
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Prostat kanseri erkeklerde en yaygın görülen tümörlerden biridir. Dosetaksel ve prednison tedavisi prostat kanserli hastalarda standart kemoterapi tedavisi olarak kabul edilmektedir. Dosetaksel tübülin depolimerizasyonunu engelleyerek, mikrotübüllerin stabilizasyonu yoluyla antitümöral etki gösteren taksan grubu kemoterapötik ilaçtır. Dosetaksel tedavisinin sistemik yan etkilerinin yanında kutanöz yan etkilere yol açtığı da bildirilmiştir. Dosetaksel kullanımı ile en sık görülen kutanöz yan etkiler alopesi, el ayak sendromu, fiks plak eritrodizestezisi, tırnak değişiklikleridir. El ayak sendromu el ve ayaklarda bilateral, simetrik yerleşim gösteren eritemden, deskuamasyon gösteren ödemli plaklara kadar değişen klinik tablolarla karşımıza çıkabilir. El ayak sendromu kemoterapi tedavisinin ilerleyen hafta veya aylarında ortaya çıktığı bildirilmiştir. Biz metastatik prostat kanserli hastalarda sık kullanılan dosetaksel kemoterapi tedavisi ile ilişkili el ayak sendromu gelişen olgumuzu sunduk.
Prostate cancer is one of the most common tumors in men. Docetaxel and prednisone treatment are accepted as standard chemotherapy in prostate cancer patients. Docetaxel is a chemotherapeutic drug of the taxane group that inhibits the depolymerization of tubulin and has an antitumoral effect through the stabilization of microtubules. It has also been reported that docetaxel therapy lead to cutaneous side effects besides systemic side effects. The most common cutaneous side effects of docetaxel are alopecia, hand foot syndrome, fixed plaque erythrodysesthesia, nail changes. Hand foot syndrome can be confronted with clinical tables ranging from bilateral, symmetrical erythema to desquamated plaques on hands and feet. It has been reported that hand foot syndrome occurred in the following weeks or months of chemotherapy treatment. We would like to present our case of hand foot syndrome associated with docetaxel chemotherapy treatment which is commonly used in patients with metastatic prostate cancer.
Prostate cancer is one of the most common tumors in men. Docetaxel and prednisone treatment are accepted as standard chemotherapy in prostate cancer patients. Docetaxel is a chemotherapeutic drug of the taxane group that inhibits the depolymerization of tubulin and has an antitumoral effect through the stabilization of microtubules. It has also been reported that docetaxel therapy lead to cutaneous side effects besides systemic side effects. The most common cutaneous side effects of docetaxel are alopecia, hand foot syndrome, fixed plaque erythrodysesthesia, nail changes. Hand foot syndrome can be confronted with clinical tables ranging from bilateral, symmetrical erythema to desquamated plaques on hands and feet. It has been reported that hand foot syndrome occurred in the following weeks or months of chemotherapy treatment. We would like to present our case of hand foot syndrome associated with docetaxel chemotherapy treatment which is commonly used in patients with metastatic prostate cancer.
Açıklama
Anahtar Kelimeler
Onkoloji
Kaynak
Acta Oncologica Turcica
WoS Q Değeri
Scopus Q Değeri
Cilt
50
Sayı
3
