Effects of different doses of tilmicosin on malondialdehyde and glutathione concentrations in mice

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dc.contributor.authorYazar, E
dc.contributor.authorOztekin, E
dc.contributor.authorSivrikaya, A
dc.contributor.authorCol, R
dc.contributor.authorElmas, M
dc.contributor.authorBas, AL
dc.date.accessioned2020-03-26T16:48:24Z
dc.date.available2020-03-26T16:48:24Z
dc.date.issued2004
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim of this study was to follow the effects of different doses of tilmicosin on malondialdehyde and reduced glutathione levels of heart and liver, and on selected haematological indices. Forty male Balb/C mice were used throughout the experiment. They were divided into four groups (n = 10), and injected subcutaneously as follows: Group I (control), with isotonic saline solution, Group 2 with 25 mg/kg body weight of tilmicosin, Group 3 with 50 mg/kg, and Group 4 with 75 mg/kg of tilmicosin in single injections. After three days, plasma, cardiac and hepatic malondialdehyde and reduced glutathione levels were measured with spectrophotometer. Red blood cell, white blood cell, platelet, haemoglobin, packed cell volume and percentage of leukocytes were also determined. At the end of the experiment, tilmicosin did not cause any statistically significant (P > 0.05) changes in haematological parameters such as red blood cells, white blood cells, platelet, haemoglobin, packed cell volume and percentage of leukocytes. Hepatic malondialdehyde and reduced glutathione levels increased (P < 0.05) only at the highest dose of tilmicosin. The results indicate that tilmicosin did not cause lipid peroxidation in the heart.en_US
dc.identifier.doi10.2754/avb200473010069en_US
dc.identifier.endpage72en_US
dc.identifier.issn0001-7213en_US
dc.identifier.issue1en_US
dc.identifier.startpage69en_US
dc.identifier.urihttps://dx.doi.org/10.2754/avb200473010069
dc.identifier.urihttps://hdl.handle.net/20.500.12395/19029
dc.identifier.volume73en_US
dc.identifier.wosWOS:000221313100011en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherVETERINARNI A FARMACEUTICKA UNIVERZITA BRNOen_US
dc.relation.ispartofACTA VETERINARIA BRNOen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjecttilmicosinen_US
dc.subjecthearten_US
dc.subjectliveren_US
dc.subjectlipid peroxidationen_US
dc.subjectmouseen_US
dc.titleEffects of different doses of tilmicosin on malondialdehyde and glutathione concentrations in miceen_US
dc.typeArticleen_US

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