Improved Solubility of Morin Using p-sulphonatocalix[4]arene as Encapsulating Agent: HPLC Analysis and their Molecular Modelling
Küçük Resim Yok
Tarih
2018
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor and Francis Inc.
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
This study reports the use of water-soluble p-sulphonatocalix[4]arene (pSC-3) as solubilizing agent to improve the water solubility of morin, an exceptional antioxidant. Stoichiometry, stability constant, and mechanism of complex were investigated by UV-Vis and HPLC analysis and characterized by FTIR spectroscopy. Results indicate that 25% morin was encapsulated on pSC-3 at pH 7.3 and phase solubility study suggested 10 fold increase in water solubility of morin while 1:1 stoichiometric ratio was confirmed by Job's plot. Binding constant for inclusion complex was found to be 6.67 × 104 M?1 calculated by using the Benesi–Hildebrand equation. In order to study the detailed structural properties of the complex, molecular mechanism approach was applied to calculate different energies associated with complex. © 2018 Taylor & Francis Group, LLC
Açıklama
Anahtar Kelimeler
Inclusion complex, molecular mechanism, Morin, p-sulphonatocalix[4]arene, solubility, stoichiometry
Kaynak
Polycyclic Aromatic Compounds
WoS Q Değeri
Scopus Q Değeri
Q3
