The evaluation of safety and analgesic efficacy of paracetamol and ibuprofen followed by impacted third molar surgery [Gömülü üçüncü molar diş ameliyatı öncesinde uygulanan parasetamol ve i?buprofenin a?rı kesici etkinli?i ve güvenli?i açısından de?erlendirilmesi]

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dc.contributor.authorÖzkan, Birkan Taha
dc.contributor.authorDurmuş, Ercan
dc.contributor.authorKalaycı, Abdullah
dc.contributor.authorKurban, Sevil
dc.contributor.authorAkça, Cennet Neslihan
dc.date.accessioned2020-03-26T18:05:50Z
dc.date.available2020-03-26T18:05:50Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAim: The aim of this prospective, randomised, single-blind, single center, parallel group study was to compare the analgesic effects and safety of a single starting dose of soluble ibuprofen and 2 g of intravenous paracetamol for postoperative pain management in patients undergoing surgical removal of lower impacted third molar. Method: 30 patients who referred for surgical removal of bilateral impacted lower third molar teeth were included in the study. The patients were divided in to two groups. In the early preoperative period, the patients received a single starting dose of either soluble ibuprofen 400 mg dissolved in 100 ml of water or 15-min intravenous infusion of paracetamol 2 gram. Surgery in each patient was performed twice, 1 impacted tooth was being removed at a time and another one was being removed 2 weeks later. Trismus, safety variables and hepatotoxicity and analgesic efficacy were evaluated. Result: The analgesic efficacy over a 24-hour period was of statistically no significant difference between 2 groups but clinical data shows that the analgesic efficacy of paracetamol group was greater than ibuprofen group. As for the mean trismus values, there was no statistically significant difference between groups. The administered dosages of the analgesics did not lead to hepatocellular injury and biochemical abnormality. Conclusion: Consequently, both administered dosages of drugs can safely be used as a single starting doses. In order to obtain more better results with analgesic efficacy and safety in use, more trials are needed for administering higher doses of paracetamol and ibuprofen.en_US
dc.identifier.endpage316en_US
dc.identifier.issn1304-3889en_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage310en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/25550
dc.identifier.volume7en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherTIP ARASTIRMALARI DERNEGIen_US
dc.relation.ispartofEuropean Journal of General Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAnalgesic efficacyen_US
dc.subjectHepatotoxicityen_US
dc.subjectImpacted third molar surgeryen_US
dc.subjectPreemptive analgesiaen_US
dc.titleThe evaluation of safety and analgesic efficacy of paracetamol and ibuprofen followed by impacted third molar surgery [Gömülü üçüncü molar diş ameliyatı öncesinde uygulanan parasetamol ve i?buprofenin a?rı kesici etkinli?i ve güvenli?i açısından de?erlendirilmesi]en_US
dc.typeArticleen_US

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