Frequency of Cytochrome 450 (CYP2C9 and CYP2C19) Genetic Polimorphisms in Patients with Colorectal Carsinoma

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dc.contributor.authorBuyukdogan, Murat
dc.contributor.authorBoruban, M. Cem
dc.contributor.authorArtac, Mehmet
dc.contributor.authorDemirel, Sennur
dc.date.accessioned2020-03-26T17:38:44Z
dc.date.available2020-03-26T17:38:44Z
dc.date.issued2009
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractColorectal cancers are important health problems particularly in developed countries, are multifactorial diseases developing by the effects of both genetic and environmental factors. In this case-control study, we evaluated the relationship between colorectal carcinoma and gene polymorphizms of CYP2C9 and CYP2C19 which are the members of CYP2C subfamily playing important roles in the metabolism of endogenous and exogenous compounds, and also assessed other possible relations with carcinogens and drugs as well as many other risk factors such as smoking, alcohol, family history of cancer and asbestos exposure. Eighty-five patients histopathologically diagnosed with colorectal carcinoma admitted to Departments of Medical Oncology and Surgery at Meram Medical Faculty and eighty-five healhty volunteers, who have no family history of cancer, were included in this study. Heterozygote and mutant genotypes of CYP2C9 and CYP2C19 genes were determined by CYP2C9*2,CYP2C9*3 and CYP2C19*2,CYP2C19*3 Mutation Detection Kits by Light Cycler Real Time Polymerase Chain Reaction. Results were statistically compared in these case-control subjects and odds ratios were used. There were no significant differences between patients with colorectal carcinoma and control groups. However, asbestos exposure ratio in patients with colorectal carcinoma was significantly higher (p < 0.05) than control subjects. Therefore, asbestos exposure may be considered as a risk factor for colorectal carcinoma.en_US
dc.identifier.endpage+en_US
dc.identifier.issn1306-133Xen_US
dc.identifier.issue3en_US
dc.identifier.startpage134en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/23560
dc.identifier.volume19en_US
dc.identifier.wosWOS:000271596100002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isotren_US
dc.publisherAKAD DOKTORLAR YAYINEVIen_US
dc.relation.ispartofUHOD-ULUSLARARASI HEMATOLOJI-ONKOLOJI DERGISIen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectColorectal carcinomaen_US
dc.subjectCytochrome P450en_US
dc.subjectCYP2C9 and CYP2C 19 Polymorphizmen_US
dc.subjectAsbestosen_US
dc.titleFrequency of Cytochrome 450 (CYP2C9 and CYP2C19) Genetic Polimorphisms in Patients with Colorectal Carsinomaen_US
dc.typeArticleen_US

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