Oksim ve klorürlerin bakteriler üzerine etkilerinin belirlenmesi
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Dosyalar
Tarih
1996-11-25
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Selçuk Üniversitesi Fen Bilimleri Enstitüsü
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Bu çalışmada aldehit ve ketonlardan çıkılarak oksimler elde edildi. Bunların değişik şartlarda NOCİ ya da klor gazı kullanılarak hidroksamik asit klorürleri sentezlendi. Ayrıca bazı oksim eterleri sentezlendi. Elde edilen bütün maddelerin antibakteriyel etkileri incelendi. Basit oksimlerden o - ve p-klor benzaldoksim, 2,4-diklor benzaldoksim, p- tolulaldoksim, oc-naftilaldoksim ve tereftalaldoksim; dioksimlerden fenil glioksim, p- klorofenil glioksim ve (3-naftil glioksim literatüre göre sentezlendi. Bifenil glioksim ise benzer şekilde elde edildi. Bu oksimler klorlanarak oksim klorürleri elde edildi. Ayrıca ;;-klorbenzaldoksimo etanol, 2,4-diklorobenzaldoksimo etanol, Tereflal aldoksimo dietanol ve fenilglioksimo dietanol sentezlendi. Sentezlenen maddelerin antibakteriyel etkilerine Gram + ve Gram - bakteriler üzerinde bakıldı. Çalışmada Sarcina lutea, Escherichia coli, Salmonella typhimurium, Pseudomanas aeruginosa ve Staphylococcus aureus bakterileri kullanıldı. Bazı oksim klorürlerinde, oksimlerine göre daha yüksek inhibisyon alanı tesbit edildi. Maddelerin bir çoğunda yüksek etki görülürken bazılarında ise hiç etki görülmedi. Yine O- eterlerin inhibisyon alanlarının birçok oksime göre çok düşük olduğu görüldü. Ayrıca araştırmada kullanılan maddelerin, Gram (+) bakterilere Gram (-)'den daha fazla etki oluşturdukları belirlendi.
In this study, a number of both aldhyde- and ketone- based oximes were synthesized. Hydroxamic acid chloride derivates of oximes were obtained by using either NOC1 or chlor gases under the different conditions. In addition, some ether derivates of oximes were also synthesized. Antibacterial effectiveness all of the synthesized material were evaluated microbiologically. Simple oximes such as 0- and p-chloro benzaldoxime, p-tolulaldoxime, ot- naphthylaldoxime and dioximes such as phenylglyoxime, p- chloro phenyl glyoxime and p-naphthyl glyoxime were synthesized according to the methods given in the literatüre. Biphenyl glyoxime was also obtained similarly. Chlorure derivates of the synthesized oximes were obtained via chlorization of the derivates. Furthermore p- chlorbenzaldoximodiethanol and phenylglyoximodiethanol were synthsized. Antibacterial effectiveness of the substances synthesized were also evaluated on Sarcina lutea, Eschericha coli. Salmonella typhimuriwn, Pseudomonas aeruginosa and Staphylococcus aureus bacteria of either Gram (-) or Gram (+) species. Some oxime chlorides showed larger inhibition zones when compared with their oximes. Most of the substances obtained in this study had high level antibacterial effectiveness. Neverthless, a few substances had no reflect on the bacteria tested. Besides, 0- ethers formed smaller inhibition zones than most of the oximes. Furthermore, substances which are used in this research are effected more Gram (+) than Gram (-).
In this study, a number of both aldhyde- and ketone- based oximes were synthesized. Hydroxamic acid chloride derivates of oximes were obtained by using either NOC1 or chlor gases under the different conditions. In addition, some ether derivates of oximes were also synthesized. Antibacterial effectiveness all of the synthesized material were evaluated microbiologically. Simple oximes such as 0- and p-chloro benzaldoxime, p-tolulaldoxime, ot- naphthylaldoxime and dioximes such as phenylglyoxime, p- chloro phenyl glyoxime and p-naphthyl glyoxime were synthesized according to the methods given in the literatüre. Biphenyl glyoxime was also obtained similarly. Chlorure derivates of the synthesized oximes were obtained via chlorization of the derivates. Furthermore p- chlorbenzaldoximodiethanol and phenylglyoximodiethanol were synthsized. Antibacterial effectiveness of the substances synthesized were also evaluated on Sarcina lutea, Eschericha coli. Salmonella typhimuriwn, Pseudomonas aeruginosa and Staphylococcus aureus bacteria of either Gram (-) or Gram (+) species. Some oxime chlorides showed larger inhibition zones when compared with their oximes. Most of the substances obtained in this study had high level antibacterial effectiveness. Neverthless, a few substances had no reflect on the bacteria tested. Besides, 0- ethers formed smaller inhibition zones than most of the oximes. Furthermore, substances which are used in this research are effected more Gram (+) than Gram (-).
Açıklama
Anahtar Kelimeler
Antimikrobiyal etki, Antimicrobial action, Oksimler, Oximes, Kimya, Chemistry
Kaynak
WoS Q Değeri
Scopus Q Değeri
Cilt
Sayı
Künye
Şeker, R. (1996). Oksim ve klorürlerin bakteriler üzerine etkilerinin belirlenmesi. Selçuk Üniversitesi, Yayımlanmış doktora tezi, Konya.
