Prognostic Significance of Tumor Grade in Early-stage Endometrioid Endometrial Cancer
Yükleniyor...
Dosyalar
Tarih
2019
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Aim: Although tumor grade has no impact on endometrial cancer stage, it carries prognostic and therapeutic importance. Surgicalmanagement and adjuvant treatment following surgery in certain patients depends on a number of factors including tumor grade.Although grade 3 tumors are included in the high-intermediate risk group, there are data demonstrating that there is a slight differencein survival between patients with grade 1 and 2 tumors in early-stage disease. In this study, we aimed to investigate the associationof grade with clinicopathological characteristics, recurrence-free and disease-specific survival in patients treated at our clinic anddiagnosed with endometrioid endometrial cancer.Material and Methods: 279 patients with early FIGO Stage endometrioid endometrial cancer treated between 2009-2018 in aUniversity hospital were included in the study. The associations between tumor grade with stage, lymphovascular space invasion(LVSI), myometrial invasion, tumor size, and survival were analyzed.Results: LVSI, 50% myometrial invasion, advanced stage and 2 cm tumor size were significantly higher in grade 3 tumors comparedto patients with grade 1 tumors. Recurrence-free and disease-specific survival were significantly lower in patients with grade 2 and3 tumors compared to patients with grade 1 tumors. In multivariate analysis of RFS and DSS, tumor grade, LVSI and stage wereindependent prognostic factors.Conclusion: According to this study, grade 2 tumors may not differ significantly from grade 3 tumors in terms of survival. Therefore,due to the potential adverse prognosis associated with grade 2 and 3 tumors, vigilance for recurrence is warranted.
Açıklama
Anahtar Kelimeler
Acil Tıp, Adli Tıp, Alerji, Anatomi ve Morfoloji, Androloji, Anestezi, Biyofizik, Biyokimya ve Moleküler Biyoloji, Biyoloji, Biyoteknoloji ve Uygulamalı Mikrobiyoloji, Cerrahi, Dermatoloji, Diş Hekimliği, Endokrinoloji ve Metabolizma, Enfeksiyon Hastalıkları, Farmakoloji ve Eczacılık, Fizyoloji, Gastroenteroloji ve Hepatoloji, Genel ve Dahili Tıp, Geriatri ve Gerontoloji, Göz Hastalıkları, Halk ve Çevre Sağlığı, Hematoloji, Hücre Biyolojisi, İmmünoloji, Kadın Hastalıkları ve Doğum, Kalp ve Kalp Damar Sistemi, Klinik Nöroloji, Kulak, Burun, Boğaz, Mikrobiyoloji, Nörolojik Bilimler, Odyoloji ve Konuşma-Dil Patolojisi, Onkoloji, Ortopedi, Patoloji, Pediatri, Periferik Damar Hastalıkları, Psikiyatri, Radyoloji, Nükleer Tıp, Tıbbi Görüntüleme, Rehabilitasyon, Romatoloji, Sağlık Bilimleri ve Hizmetleri, Solunum Sistemi, Spor Bilimleri, Tamamlayıcı ve Entegre Tıp, Temel Sağlık Hizmetleri, Tıbbi Araştırmalar Deneysel, Tıbbi Etik, Tıbbi İnformatik, Tıbbi Laboratuar Teknolojisi, Toksikoloji, Transplantasyon, Tropik Tıp, Üroloji ve Nefroloji, Yoğun Bakım, Tıp
Kaynak
Annals of Medical Research
WoS Q Değeri
Scopus Q Değeri
Cilt
26
Sayı
9
Künye
Akar, S., Harmankaya, İ., Çelik, Ç. (2019). Prognostic Significance of Tumor Grade in Early-stage Endometrioid Endometrial Cancer. Annals of Medical Research, 26(9), 1777-1781.
