Hematological and Biochemical Effect of Subcutaneous Administration of Robenacoxib in Different Goat Breeds
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Tarih
2023 Aralık
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Selçuk Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Sunulan çalışmada sağlıklı Alpin ve Saanen ırkı keçilere robenacoxibin deri altı yolla uygulamasından 24 saat sonra hematolojik ve biyokimyasal parametreler üzerindeki etkisinin belirlenmesi amaçlandı. Gereç ve Yöntem: Çalışmada 12 Alpin (n=6) ve Saanen (n=6) ırkı, sağlıklı keçi kullanıldı. Alpin ve Saanen ırkı keçilere robenacoxib 4 mg/kg dozda, tek sefer deri altı yolla uygulandı. İlaç uygulamasından önce (0. saat) ve 24. saatte kan örnekleri toplandı. Hematolojik ve biyokimyasal parametreler hematoloji analizörü ve biyokimya otoanalizörü cihazları kullanılarak analiz edildi. Bulgular: Her iki keçi ırkının klinik muayene bulgularında değişiklik gözlenmedi. Hematolojik ve biyokimyasal parametrelerdeki istatistiksel farklılıklar her iki keçi ırkında fizyolojik sınırlar içerisinde belirlendi. Alpin ırkı keçilerde beyaz kan hücresi, kırmızı kan hücresi, lenfosit değeri düşük ve % monosit değeri yüksek belirlendi. Saanen ırkı keçilerde kırmızı kan hücresi, hemoglobin ve hematokrit değerlerinin düşük, ortalama korpüsküler hacim ve ortalama korpüsküler hemoglobin değerlerinin ise 24 saatte yüksek olduğu gözlemlendi. Robenacoxib her iki keçi ırkında da kan üre nitrojen değerini arttırırken, Saanen keçilerinde kreatinin değerini düşürdü. Öneri: Robenacoxibin Alpin ve Saanen ırkı keçilere uygulanmasından sonra hematolojik ve biyokimyasal parametrelerde önemli bir değişiklik belirlenmedi. Sonuç olarak, yüksek doz ve tekrarlanan uygulamalarda, karaciğer ve böbrek fonksiyon bozukluklarında, yaş, ırk, farklı fizyolojik durumlarda robenacoxibin etkilerinin araştırılacağı çalışmalara ihtiyaç vardır. Kan profilinde herhangi bir olumsuz etki görülmemesi nedeniyle robenacoxibin keçilerde ağrı ve inflamasyonun önlenmesinde alternatif bir NSAID olarak kullanılabileceği değerlendirildi.
Aim:This study aimedto investigate the effect of robenacoxibonhematological and biochemical parameters in healthy Alpine and Saanen goats 24 hours after subcutaneous administration. Materials and Methods: 12 healthy Alpine (n=6) and Saanen (n=6) breed goats were used. Robenacoxib was administered to Alpine and Saanen goats at a dose of 4 mg/kg once subcutaneously. Blood samples were collected before drug administration (0 hour) and then 24-hours. Hematological and biochemical parameters were analyzed using a hematology analyzer and biochemistry auto analyzer, respectively. Results: No change was observed in the clinical examination findings of both goat breeds. Statistical differences in hematological and biochemical parameters were determined within physiological limits in both goat breeds. The white blood cell, red blood cell and lymphocyte values were found to be low, and the monocyte% value was found to be high in Alpine goats. Decreases in red blood cell, hemoglobin and hematocrit levels and increases in the mean corpuscular volume and mean corpuscular hemoglobin values were observed at 24-hours in Saanen goats. Robenacoxib increases blood urea nitrogen value in both goat breeds, it decreases creatinine value in Saanen goats. Conclusion: There were no significant changes in hematological and biochemical parameters after robenacoxib administrations to Alpine and Saanen goats. Consequently, further studies are needed to investigate the effects of robenacoxib in high-dose and repeated administrations, liver and kidney dysfunctions, different age, breed, and physiological conditions. It was evaluated that robenacoxib could be used as an alternative NSAID to prevent pain and inflammation in goats, since no adverse effect was observed in the blood profile.
Aim:This study aimedto investigate the effect of robenacoxibonhematological and biochemical parameters in healthy Alpine and Saanen goats 24 hours after subcutaneous administration. Materials and Methods: 12 healthy Alpine (n=6) and Saanen (n=6) breed goats were used. Robenacoxib was administered to Alpine and Saanen goats at a dose of 4 mg/kg once subcutaneously. Blood samples were collected before drug administration (0 hour) and then 24-hours. Hematological and biochemical parameters were analyzed using a hematology analyzer and biochemistry auto analyzer, respectively. Results: No change was observed in the clinical examination findings of both goat breeds. Statistical differences in hematological and biochemical parameters were determined within physiological limits in both goat breeds. The white blood cell, red blood cell and lymphocyte values were found to be low, and the monocyte% value was found to be high in Alpine goats. Decreases in red blood cell, hemoglobin and hematocrit levels and increases in the mean corpuscular volume and mean corpuscular hemoglobin values were observed at 24-hours in Saanen goats. Robenacoxib increases blood urea nitrogen value in both goat breeds, it decreases creatinine value in Saanen goats. Conclusion: There were no significant changes in hematological and biochemical parameters after robenacoxib administrations to Alpine and Saanen goats. Consequently, further studies are needed to investigate the effects of robenacoxib in high-dose and repeated administrations, liver and kidney dysfunctions, different age, breed, and physiological conditions. It was evaluated that robenacoxib could be used as an alternative NSAID to prevent pain and inflammation in goats, since no adverse effect was observed in the blood profile.
Açıklama
Anahtar Kelimeler
Biyokimyasal, deri altı, hematolojik, keçi ırkı, robenacoxib, Biochemical, goat breed, hematological, subcutaneous
Kaynak
Eurasian Journal of Veterinary Sciences
WoS Q Değeri
Scopus Q Değeri
Cilt
39
Sayı
4
Künye
Özdemir Kütahya, Z., Piner Benli, P., (2023). Hematological and Biochemical Effect of Subcutaneous Administration of Robenacoxib in Different Goat Breeds. Eurasian Journal of Veterinary Sciences, 39(4), 150-155.
DOI: 10.15312/EurasianJVetSci.2023.411
