Association of Polymorphisms in TCF7L2 Gene with Gastric Cancer Risk: A Preliminary Study in Turkish

Basit Öğe Kaydı
dc.contributor.authorKaya, Dudu Erkoc
dc.contributor.authorArikoglu, Hilal
dc.contributor.authorSumen, Incilay Celik
dc.contributor.authorAvci, Ebru
dc.contributor.authorAta, Ozlen
dc.contributor.authorArslan, Emine
dc.date.accessioned2020-03-26T19:01:01Z
dc.date.available2020-03-26T19:01:01Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAim: The Transcription factor 7-like 2 (TCF7L2) gene, located on chromosome 10q25.3, encodes a transcription factor, which contains a high mobility group box, demonstrated in association with many cancer types. This factor is a critical part of Wnt/beta-catenin signaling pathway that plays key roles in regulation of embryonic development and homeostasis in mature tissues. It is known that the constant activation of Wnt/beta-catenin signaling pathway can cause cancer development. In this study, it is aimed to reveal the association between rs7903146C>T and rs12255372G/T single nucleotide polymorphisms in TCF7L2 gene, the key effector of Wnt/beta-catenin signaling pathway, and gastric cancer and to determine associated risk alleles. Material and Method: In our study, polymorphisms in TCF7L2 gene were genotyped using PCR-PFLP technique in 38 patients with gastric cancer and 48 healthy individuals. The obtained data were statistically analyzed and p<0.06 was accepted significant in all assessments. Results: No significant association was determined between rs7903146C>T and disease (p> 0.05) while 122553720>T polymorphism was associated with the disease under additive model (OR: 0.366 195% Cl: 0.135-0.989] p=0.047). Discussion: This is the first study to examine the association between TCF7L2 gene and gastric cancer risk in Turkish population and suggests that rs12255372C>T could be a potential indicator for gastric cancer. On the other hand, further studies are required which will be carry out in more increased number of samples in a wider population.en_US
dc.identifier.doi10.4328/JCAM.3648en_US
dc.identifier.endpage800en_US
dc.identifier.issn1309-0720en_US
dc.identifier.issn1309-2014en_US
dc.identifier.pmid#YOKen_US
dc.identifier.startpage797en_US
dc.identifier.urihttps://dx.doi.org/10.4328/JCAM.3648
dc.identifier.urihttps://hdl.handle.net/20.500.12395/31876
dc.identifier.volume6en_US
dc.identifier.wosWOS:000215600200017en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherDERMAN MEDICAL PUBLen_US
dc.relation.ispartofJOURNAL OF CLINICAL AND ANALYTICAL MEDICINEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectTCF7L2 Geneen_US
dc.subjectSNPen_US
dc.subjectGastric Canceren_US
dc.subjectTurkishen_US
dc.titleAssociation of Polymorphisms in TCF7L2 Gene with Gastric Cancer Risk: A Preliminary Study in Turkishen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu