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Öğe 3 ',4 '-Dihydroxyflavonol attenuates spatial learning and memory impairments in global cerebral ischemia(TAYLOR & FRANCIS LTD, 2017) Öz, Mehmet; Demir, Enver Ahmet; Çalışkan, Merve; Moğulkoç, Rasim; Baltacı, Abdulkerim Kasım; Atalık, Kısmet Esra NurullahoğluObjectives: In the present study, effects of 3', 4'-dihydroxyflavonol (DiOHF) on anxiety-like behavior, and learning and memory were investigated in a model of transient global cerebral ischemia and reperfusion. Methods: The animals were assigned to sham-operated, ischemia, and two DiOHF-treated (10 mg/kg i. p.) groups. DiOHF was administered at 1 hour before and immediately after the ischemia. Male rats were subjected to bilateral common carotid artery occlusion to induce acute cerebral ischemia for 20 minutes, followed by reperfusion for 7 days. The openfield, elevated plus maze (EPM), and Morris water maze tests were used to evaluate the effects of DiOHF treatment on ischemia-induced locomotor activity, anxiety-like behavior, and spatial and recognition memory impairments, respectively. Results: In the open field test, locomotor activity in the ischemic rats was not altered 6 days after the ischemia, nor was anxiety-like behavior, which was evaluated with the EPM (P > 0.05). In the water-maze test, cerebral ischemia significantly decreased the exploration time in the target quadrant, and the platform crossing counts were lower (P < 0.05) in the probe trial test; this memory impairment was significantly improved by DiOHF applied 1 hour before and immediately after ischemia (P < 0.05). Discussion: All together, these findings suggest that DiOHF reverses spatial learning and memory deficits resulting from transient global ischemia but has no significant effect on anxiety-like behavior.Öğe Co-administration of cisplatin and curcumin does not alter mood-associated behaviors(COMENIUS UNIV, 2016) Demir, Enver Ahmet; Öz, Mehmet; Alp, Muhammed İkbal; Gergerlioğlu, Hasan Serdar; Atalık, Kısmet Esra Nurullahoğlu; Yerlikaya, Fatma HümeyraOBJECTIVES: Cisplatin (cis-diamminedichloroplatinum (II)) is a widely-used platinum-based chemotherapeutic agent which has dose-limiting side-effects. Also, the drug resistance is another instance that decreases treatment success in cisplatin chemotherapy. The growing body of evidence suggests that curcumin, a polyphenolic compound extracted from the spice turmeric, may exert synergistic effects and sensitize malign cells to cisplatin, while alleviating cytotoxicity-related side-effects. The present study was aimed to investigate mood-associated interactions between cisplatin and curcumin. MATERIALS AND METHODS: Thirty-four adult male Wistar albino rats were randomly assigned to four groups as control, curcumin (300 mg/kg/day, p.o. for 5 weeks), cisplatin (5 mg/kg/week, i.p. for 5 weeks), and curcumin plus cisplatin (same doses as above). The open field, elevated plus maze, and forced swim tests were engaged to evaluate mood-associated behaviors. RESULTS: We demonstrated that depression- and anxiety-like behaviors were not altered by the administration of curcumin along with the chronic cisplatin treatment. CONCLUSION: According to the results of the present study, we concluded that curcumin might be regarded as a safe adjuvant in cisplatin chemotherapy in terms of the mood-associated behaviors (Fig. 4, Ref 41).Öğe The comparison of preemptive analgesic effects of curcumin and diclofenac(COMENIUS UNIV, 2014) Atalık, Kısmet Esra Nurullahoğlu; Okudan, Nilsel; Belviranlı, Muaz; Öz, MehmetObjective: Preemptive analgesia is an antinociceptive treatment that prevents central sensitization. Antinociceptive effects of diclofenac are well-known. The aim of this study was to investigate preemptive analgesic effects of curcumin and diclofenac, before acute and inflammatory induced pain in rat model. Material and methods: Fourty eight old female (n = 6 in each group) Wistar Albino rats were included in the study. Paw movements in response to paw flinching in response to formalin injection or thermal stimulation were compared after curcumin (400 mg kg(-1), p.o.) and diclofenac (10 mg kg(-1), i.p.) administration. Saline was used as a control. The solvent ethanol was administered in another group of rats. Preemptive analgesic effect was significant in both tests when curcumin and diclofenac was administrated before the pain stimuli. Results: Oral administration of curcumin and intraperitoneal injection of diclofenac increase the response time in hot plate test and decrease the number of flinches in formalin test (p < 0.001 vs p < 0.05). Conclusion: These results suggest that curcunnin had preemptive analgesic effects on acute thermal, and inflammatory induced pain in rats as diclofenac (Fig. 2, Ref. 35). Text in PDF www.elis.sk.Öğe Comparison of the efficacy of prednisolone, montelukast, and omalizumab in an experimental allergic rhinitis model(TUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEY, 2014) Bozkurt, Mete Kaan; Tülek, Baykal; Bozkurt, Banu; Akyürek, Nalan; Öz, Mehmet; Kıyıcı, AyselAim: To compare the efficacy of prednisolone, montelukast, and omalizumab in reducing allergic symptoms and inflammation at tissue level in an experimental allergic rhinitis model. Materials and methods: Forty Sprague Dawley rats were randomized into 5 groups as naive (NS/NC), sensitized/challenged (S/C) by subcutaneous ovalbumin antigen injection, and montelukast-, prednisolone-, and omalizumab- treated groups. A nasal allergen challenge was performed every day from day 20 to day 26. The number of sneezes and nasal/eye rubbing movements, IL-4 and CysLT levels in serum, nasal and bronchoalveolar lavage fluids determined by ELISA, and histopathological findings of nasal mucosa, sinus, and lung tissues were compared. Results: All of the treatments significantly controlled the allergic symptoms of sneezing and nasal/eye rubbing (P < 0.05). IL-4 and CysLT levels on days 20 and 26 were significantly higher in the S/C group compared to the NS/NC group (P < 0.05). Montelukast significantly decreased serum and nasal IL-4 and CysLT levels (P < 0.05), prednisolone decreased nasal lavage IL-4 and CysLT levels (P < 0.05), and omalizumab lowered nasal lavage CysLT levels (P < 0.05). Conclusion: Prednisolone, montelukast, and omalizumab were found to be effective in controlling the allergic symptoms of allergic rhinitis and upper/lower airway inflammation in an experimental allergic rhinitis model.Öğe Curcumin improves spatial memory and decreases oxidative damage in aged female rats(SPRINGER, 2013) Belviranlı, Muaz; Okudan, Nilsel; Atalık, Kısmet Esra Nurullahoğlu; Öz, MehmetAging induced cognitive impairment has been well documented for many years and several antioxidant strategies have been developed against this impairment. Curcumin is the active component of curcuma longa and has shown antioxidant, antiinflamatory and neuroprotective properties. We hypothesized that curcumin would have an influence on cognitive functions in aged female rats. The purpose of the present study was to investigate the effects of curcumin supplementation on cognitive impairment evaluated by Morris water maze (MWM) as well as the oxidative stress induced by aging in female rats. Rats were randomly divided into either control or curcumin-supplemented groups. Curcumin or vehicle (corn oil) were given once daily for a period of 12 days, beginning 7 days prior to and 5 days during the behavioral tests. Behavioral assessment was performed in MWM. At the end of the behavioral test, blood samples and brain tissues were taken for the analysis of malondialdeyde (MDA), protein carbonyl and glutathione levels. During the training session, curcumin supplementation decreased latency to reach to the platform and the total distance traveled. During the probe trial, curcumin supplementation increased the number of platform crossings. In addition to the behavioral testing, biochemical results showed that MDA levels decreased in brain tissue by curcumin supplementation. It may be concluded that, curcumin supplementation improves cognitive functions by decreasing the lipid peroxidation in brain tissue of aged female rats.Öğe Cytokeratin 18 and h-FABP levels in intestinal ischemiareperfusion injury: Role of coenzyme Q10(2013) Belviranlı, Muaz; Okudan, Nilsel; Gökbel, Hakkı; Kıyıcı, Aysel; Öz, Mehmet; Kumak, AyşeAim: The objective of this study was to investigate whether coenzyme Q10 (CoQ10) supplementation affects M30 and heart-type fatty acid binding protein (h-FABP) levels in intestinal ischemiareperfusion injury-induced rats. Materials and methods: Thirty-two male Wistar rats were randomly divided into 4 groups. 1) Sham: Animals exposed to laparotomy without clamping the superior mesenteric artery (SMA); 2) ischemiareperfusion (IR): rats exposed to laparotomy with occlusion of the SMA for 45 min, followed by 120 min of reperfusion period; 3) CoQ10 plus sham: 10 mg kg body weight 1 CoQ10 was administrated via intraperitoneal injection for 20 days, and thereafter animals were exposed to laparotomy without clamping the SMA; 4) CoQ10 plus IR: 10 mg kg body weight 1 CoQ10 was administrated via intraperitoneal injection for 20 days and thereafter animals were exposed to laparotomy with occlusion of the SMA for 45 min, followed by 120 min of reperfusion period. Blood samples were taken by cardiac puncture for the analysis of serum h-FABP and M30 levels. Results: There was no difference among the groups for serum h-FABP and M30 antigen levels. Conclusion: Neither intestinal ischemiareperfusion injury nor CoQ10 supplementation affect serum h-FABP and M30 levels in rats.Öğe The effect of cyanoacrylate in esophagocutaneous leakages occurring after esophageal anastomosis(ELSEVIER IRELAND LTD, 2009) Yurtçu, Müslim; Arbağ, Hamdi; Çağlayan, Osman; Abasıyanık, Adnan; Öz, MehmetObjective: Esophageal leakage (EL) continues to be a challenging pediatric surgical problem. The aim of this study was to investigate the effect of cyanoacrylate (Cy) in EL followed esophageal repair (ER). Methods: Twelve rabbits were divided into control (C) and leakage (L) groups. A I cm-length transverse esophageal incision at the level of the cervical region was made. In both groups, feeding was started orally 24 h after the surgery for leakage creation. On postoperative day 7, primary repair was carried out in the C group and Cy instillation was performed in the L group. Esophagographic analysis was carried out on postoperative day 9 and the animals were fed orally on the same day on the condition that there was no esophageal leakage. The rabbits were sacrificed to measure diameters of the OR line, bursting pressure (BP), and hydroxyproline (HP) levels in the repaired cervical esophageal segment (RCES) 2 months later. Results: The values of BP and HP in the C group were significantly higher than those in the L group. The diameters of the OR line in the L group were significantly greater compared to those in the C group. Conclusions: Cy glue instillation seems to be the ideal treatment for esophageal anastomosis leakages as shown by increased diameters of the OR line and decreased HP levels. (C) 2009 Elsevier Ireland Ltd. All rights reserved.Öğe Effect of different doses of Quercetin supplementation on element levels of brain tissue in diabetic rats(WILEY-BLACKWELL, 2014) Demir, Enver Ahmet; Yazgan, Betül; Öz, Mehmet; Alp, Muhammed İkbal; Gergerlioğlu, Hasan Serdar; Moğulkoç, Rasim; Baltacı, Abdulkerim Kasım[Abstract not Available]Öğe Effects of Cisplatin and Curcumin on the Hypothalamic-Pituitary-Adrenal Axis(WILEY-BLACKWELL, 2015) Öz, Mehmet; Demir, Enver Ahmet; Gergerlioğlu, Hasan Serdar; Atalık, Kısmet Esra Nurullahoğlu; Yerlikaya, Fatma Hümeyra[Abstract not Available]Öğe Effects of exercise and caffeic acid phenethyl ester after chronic exercise rat model(JOURNAL SPORTS SCIENCE & MEDICINE, 2011) Alp, Ayşe; Büyükbaş, Sadık; Alp, Harun; Gergerlioğlu, H. Serdar; Öz, Mehmet; Başarali, M. Kemal; Kıyıcı, AyselIn order to understand whether exercise and caffeic acid phenethyl ester (CAPE) has an effect on obesity and weight control, we investigated the effects of CAPE, and exercise on lipid parameters (triglyceride, total cholesterol, HDL-C, LDLC), and adipokine substances such as leptin and resistin in rats. 40 male rat were randomly assigned into 4 groups. It was determined that CAPE does not have any significant effect on these parameters but that lipid parameters and leptin values in exercise groups decreased considerably, while no significant change occurred in resistin levels. In order to understand whether diet has an effect on exercise, body weights of all animal groups in pre and post-exercise were compared. A significant weight gain was observed (p = 0.005) in all groups. This study concluded that exercise has a considerable effect on leptin and lipid parameters; however, exercise alone was not sufficient for weight control and could be effective in weight control only when accompanied by a restricted diet.Öğe Effects of the Environmental Enrichment on Learning and Memory in High-Fat Diet-Fed Rats(WILEY-BLACKWELL, 2015) Öz, Mehmet; Demir, Enver Ahmet; Gergerlioğlu, Hasan Serdar; Atalık, Kısmet Esra Nurullahoğlu; Yerlikaya, Fatma Hümeyra[Abstract not Available]Öğe Environmental enrichment reverses cognitive impairments provoked by Western diet in rats: Role of corticosteroid receptors(PERGAMON-ELSEVIER SCIENCE LTD, 2016) Gergerlioğlu, Hasan Serdar; Öz, Mehmet; Demir, Enver Ahmet; Atalık, Kısmet Esra Nurullahoğlu; Yerlikaya, Fatma HümeyraAims: Previous studies demonstrated that the Western diet (WD), which is rich in saturated fat (HFD) and refined sugar (HSU), is related to the impairments of hippocampus-dependent learning and memory and forebrain synaptic plasticity in rodents. The environmental enrichment (EE) has been shown to enhance learning and memory in theHFD-induced cognitive deficits, but the exact mechanismis still not clearly understood. Therefore, the present study aimed to clarify the effects of the EE on spatial memory in WD-fed rats, and to analyze the potential role of corticosteroid receptors in the EE conditioning. Main methods: MaleWistar albino rats were housed in either an enriched or standard environment and fed with the HFD (35% of energy as fat), HSU (100% of carbohydrate as sucrose) or standard rat chowfor 4 weeks. Weused the Morris' water maze test (MWM) to assess the learning and memory performance, and measured plasma levels of corticosterone (CORT) and adrenocorticotropic hormone (ACTH), as well as glucocorticoid (GR) and mineralocorticoid receptor (MR) levels in the hippocampus. Key findings: The results showed that HFD-fed rats displayed poorer learning and memory performance evaluated with MWM than controls. The EE reversed the cognitive deficits caused by the HFD. In addition, the EE resulted in an increase of GR and MR levels without affecting plasma CORT and ACTH concentrations. Significance: Based on these findings, it could be suggested that the EE plays an important role in amelioration of the HFD-induced cognitive impairments, but this intervention is independent of the hypothalamic-pituitaryadrenal axis and hippocampal corticosteroid receptor levels. (C) 2016 Elsevier Inc. All rights reserved.Öğe Haemostatic Role and Histopathological Effects of a New Haemostatic Agent in A Rat Bladder Haemorrhage Model: An Experimental Trial(WILEY-BLACKWELL, 2010) Kılıç, Özcan; Gönen, Murat; Acar, Kadir; Yurdakul, Talat; Avunduk, Mustafa Cihat; Esen, Hacı Hasan; Öz, MehmetOBJECTIVE To investigate the haemostatic efficacy and histopathological effects of a new haemostatic agent, Ankaferd BloodStopper (R) (ABS; Ankaferd Drug Cosmetic Co., Istanbul, Turkey) in a rat bladder haemorrhage model. ABS is a unique combination of five plant extracts that has been used in Turkish traditional medicine as a haemostatic agent for external traumatic bleeds. MATERIALS AND METHODS In all, 20 male Sprague-Dawley rats were divided into two equal groups. In both groups, the mucosa was damaged on the posterior wall (PW) of the bladder. The liquid form of ABS was applied to the bleeding area of one group (group 1) and 0.9% NaCl to the bleeding area of the other group (group 2, controls). The solutions were applied drop by drop with a 2 mL injector until the bleeding stopped and the bleeding times recorded. For histopathological examination, two tissue samples were taken from all rats in each group; one from the damaged mucosa in the PW and one from undamaged mucosa in the lateral wall (LW). Two sections were prepared from all samples. One section was stained with haematoxylin and eosin (H&E), and the rest was used for immunohistochemical staining for fibronectin. RESULTS The mean bleeding times were 65 s and 147 s for groups 1 and 2, respectively (P < 0.001). In the pathological specimens stained with H&E, fibrosis and other studied pathological features were similar in the LW samples in groups 1 and 2. Similarly, there were no differences between the PW samples of groups 1 and 2. In the pathological specimens stained for fibronectin, the number of attenuated cells was similar in the LWs of group 1 and 2 (P = 0.21) as well as in the PWs of each group (P = 0.066). CONCLUSIONS ABS decreased bleeding time and did not increase fibrotic reactions in rat bladder tissue.Öğe Hipotalamik-hipofizer-adrenal Aks Üzerine Sisplatin ve Kurkuminin Etkileri(Selçuk Üniversitesi, 2017 Mart) Öz, Mehmet; Demir, Enver Ahmet; Gergerlioğlu, Hasan Serdar; Atalık, Kısmet Esra Nurullahoğlu; Yerlikaya, Fatma HümeyraAmaç: Son yıllarda zerdeçaldaki aktif polifenol olan kurkumininsisplatin içeren kemoterapi rejimlerinde sinerjistik bir role sahip olduğunu gösteren bilgiler artmaktadır. Kurkuminin güvenli bir adjuvan olduğunu göstermek için söz konusu ajanların sistemik etkileşimlerinin araştırılması gerektiğinden bu polifenolünsisplatin uygulanan sıçanlarda hipotalamik-hipofizer-adrenal (HPA) aksa etkilerinin incelemesi amaçlandı. Gereç ve Yöntem: Toplamda 34 erkek Wistar sıçan kontrol (n=7), sisplatin (n=10), kurkumin(n=7) ve sisplatin + kurkumin (n=10) olmak üzere dört gruba ayrıldı. Sisplatin ve kurkumin gruplarındaki sıçanlara 5 hafta süresince (sırasıyla) 5 mg/kg/hafta, i.p. sisplatin ve 300 mg/ kg/gün, p.o. kurkumin uygulandı. Sisplatin + kurkumin grubu aynı dozlarda hem sisplatin hem kurkumin aldı. Kontrol grubuna yalnızca taşıyıcı (fizyolojik salin ve mısır yağı) verildi. Hayvanlar adrenokortikotropik hormon (ACTH) ve kortikosteron (CORT) ölçümleri için kan elde etmek maksadıyla eksanguine edildi. Beyin çıkarıldı ve hipokampal dokuda mineralokortikoid (MR) ve glukokortikoid (GR) reseptörleri belirlendi. Analizler ELISA yöntemiyle gerçekleştirildi. Bulgular: Sisplatin ve kurkumin tedavilerinin araştırılan parametreleri bozmadığını bulduk (p>0.05). Ayrıca, kurkumin ve sisplatinin birlikte uygulanmasının kontrollere kıyasla ACTH ve CORT’un plazma konsantrasyonları ile hipokampal MR ve GR seviyelerini değiştirmediğini gözlendi (p>0.05). Sonuç: Sonuçlarımıza göre tek başına veya kombine halde sisplatin ve kurkumin tedavisi HPA aksını etkilememektedir.Öğe Impact of enriched environment on production of tau, amyloid precursor protein and, amyloid-beta peptide in high-fat and high-sucrose-fed rats(CAMBRIDGE UNIV PRESS, 2017) Selvi, Yavuz; Gergerlioğlu, Hasan Serdar; Akbaba, Nursel; Öz, Mehmet; Kandeğer, Ali; Demir, Enver Ahmet; Yerlikaya, Fatma HümeyraObjective: The Western-type diet is associated with an elevated risk of Alzheimer's disease and other milder forms of cognitive impairment. The aim of the present study was to investigate the effects of the environmental enrichment on amyloid and tau pathology in high-fat and high-sucrose-fed rats. Methods: In total, 40 adult male rats were categorised into two main groups according to their housing conditions: enriched environment (EE, n = 16) and standard housing condition (n = 24). The groups were further divided into five subgroups that received standard diet, high-fat diet, and high-sucrose diet. We performed the analysis of amyloid beta-peptide (A beta) (1-40), A beta(1-42), amyloid precursor protein (APP), and tau levels in the hippocampus of rats that were maintained under standard housing conditions or exposed to an EE. Results: The EE decreased the A beta(1-40), A beta(1-42), APP, and tau levels in high-fat and high-sucrose-fed rats. Conclusion: This observation shows that EE may rescue diet-induced amyloid and tau pathology.Öğe Is the Rabbit Knee a Suitable Model for the Human Interphalangeal and Metacarphophalangeal Joints of the Hand?(TURKISH ASSOC ORTHOPAEDICS TRAUMATOLOGY, 2010) Karalezli, Nazım; Durduran, S. Savaş; Ogün, C. Tunç; Uysal, İsmihan İlknur; Ünver Doğan, Nadire; Öz, MehmetObjectives: The purpose of this study was to assess the suitability of the rabbit knee as a small joint model for the human interphalangeal and metacarphophalangeal joints of the hand. Methods: The proximal joint surface areas of 47 middle phalanges, the proximal and distal joint surface areas of 90 proximal phalanges, and the distal joint surface areas of 42 metacarpals of various human cadavers were calculated and compared with the distal femoral and proximal tibial joint surface areas of 20 knee of 10 New Zealand white rabbits by a photogrammetric method. Results: The mean joint surface area of the rabbit proximal tibia was larger than the proximal joint surface area of the middle phalanx, the distal joint surface area of the proximal phalanx, the proximal joint surface area of the proximal phalanx, and the distal joint surface area of the metacarpal. The mean joint surface area of the rabbit distal femur was larger than that of the middle phalanx, but similar to the proximal joint surface area of the proximal phalanx, and that of the distal metacarpal and distal proximal phalanx. Conclusion: The rabbit knee is not suitable model for the human interphalangeal and metacarphophalangeal joints of the hand. There is still a lack of an appropriate animal model for the small joints of the hand.Öğe An oblique anastomosis has more linear length than a transverse anastomosis of a tubular structure in oesophageal anastomosis(SPRINGER, 2009) Yurtçu, Müslim; Abasıyanık, Adnan; Arbağ, Hamdi; Öz, MehmetOesophageal stricture continues to be a challenging paediatric surgical problem. This study aimed to compare the results of oblique and transverse anastomosis to prevent anastomotic stricture that occurred following oesophageal repairs. Twelve New Zealand rabbits were divided equally into two groups: oblique (O) and transverse (T). A 1-cm-long tract of the cervical oesophagus was resected through a cervical incision in both groups. Anastomosis was performed in both groups. Oesophagographic analysis was carried out on postoperative day 7 and the animals were fed orally on the same day on the condition that there was no oesophageal leakage. The rabbits were killed to measure diameters of the oesophageal lumen and bursting pressure (BP) in the anastomosis region 8 weeks later. The diameters of the oesophageal anastomosis lines (3.9 +/- A 0.10 mm) in the O group were significantly greater than those (1.9 +/- A 0.09 mm) in the T group (P < 0.05). The values of BP (189 +/- A 10 mmHg) in the O group were also significantly higher than those (116 +/- A 4 mmHg) in the T group (P < 0.05). Our results suggested that oblique anastomosis is a better surgical procedure for preventing oesophageal stricture, as shown by the increased diameters of oesophageal anastomosis lines and BP.Öğe Role of curcumin in mesenteric ischemia - reperfusion injury in rats(COMENIUS UNIV, 2012) Atalık, Kısmet Esra Nurullahoğlu; Okudan, Nilsel; Belviranlı, Muaz; Gökbel, Hakkı; Öz, Mehmet; Esen, H.Background: Curcumin is an antioxidant molecule that has been shown to attenuate ischemia/reperfusion (I/R) injury in several organ systems. In the present study, we aimed to evaluate the possible effects of curcumin on contractile response to agonists and histopathological alterations in rat esophagus subjected to mesenteric I/R. Materials and methods: Adult male Wistar albino rats were randomly allocated to 4 groups, namely group I: sham-operated animals (n=10); group II: animals subdued to I/R injury only (n=10) and laparotomy; 45 minutes of superior mesenteric artery ligation were followed by 2 hours of reperfusion, group III: curcumin/sham (n=10); 20 days before I/R, curcumin (200 mg/kg/) was administered by gastric gavage, and group IV: curcumin-I/R (n=10). Mesenteric ischemia/reperfusion model was generated by clamping the superior mesenteric artery for 45 min followed by reperfusion for 2 h. Oral administration of curcumin by gavage at a dose of 200 mg/kg/day lasted 20 days just before inducing the mesenteric ischemia. At the end of reperfusion period, all animals were sacrificed and esophagus samples were collected to assess the contractile response to agonists and histopathological alterations. Results: Ischemia/reperfusion significantly decreased the contractile responses to carbachol and KCl and this decrease was attenuated by curcumin. Pretreatment with curcumin caused a remarkable decrease in histopathological parameters such as edema, congestion and inflammatory cells. Conclusions: The results of the present study demonstrate for the first time that curcumin can attenuate the esophageal injury associated with I/R (Tab. 4, Fig. 3, Ref. 32). Full Text in PDF www.elis.sk.Öğe Sıçanlarda spirulina desteğinin egzersize bağlı oksidatif hasara ve dayanıklılık kapasitesine etkileri(Selçuk Üniversitesi Sağlık Bilimleri Enstitüsü, 2013) Öz, Mehmet; Gökbel, HakkıBu çalışma, spirulinanın akut ve kronik yüzme egzersizine bağlı oksidatif stres ve antioksidan savunmaya ve akut tüketici egzersizi devam ettirebilme kapasitesine etkilerini değerlendirmek amacıyla yapıldı. Çalışmada 48 adet Wistar soyunda ve 352±27 g ağırlığında erişkin erkek sıçan kullanıldı. Tüm sıçanlar rastgele seçimle her grupta 8 sıçan olacak şekilde 6 gruba bölündü. Kontrol (KON) grubu çeşme suyu aldı. Spirulina (SP) grubu 6 hafta süresince her gün oral yolla 750 mg/kg spirulina aldı. Kronik Egzersiz (KE) grubuna haftada 5 gün, günde bir saat olmak üzere 6 hafta boyunca yüzme egzersizi yaptırıldı. Kronik Egzersiz + Spirulina (KES) grubuna kronik egzersiz yaptırıldı ve spirulina verildi. Tükenme Egzersizi (T) grubu tükeninceye kadar yüzdürüldü. Tükenme Egzersizi + Spirulina (TS) grubu 6 haftalık spirulina takviyesi sonrası tükeninceye kadar yüzdürüldü. Çalışma sonunda T ve TS grupları egzersizden hemen sonra, diğer gruplar son egzersiz oturumundan 24 saat sonra sakrifiye edildi. Plazma, karaciğer ve iskelet kası dokusu toplandı. Plazmada kreatin kinaz (CK), kreatin kinaz MB, laktat dehidrogenaz ve ürik asit, tüm örneklerden malondialdehit (MDA), miyeloperoksidaz, ksantin oksidaz (XO), süperoksit dismutaz (SOD), katalaz, glutatyon peroksidaz ve antioksidan aktivite tayinleri yapıldı. Spirulina takviyesi sonrası sıçanların vücut ağırlığında gözlenen değişiklikler anlamlı değildi. Tükenme süreleri açısından T ve TS grupları arasında fark bulunamadı. Spirulina takviyesi tükenme egzersizine bağlı plazma CK aktivitesinde meydana gelen artışta düzelmeye yol açtı. Kronik egzersiz plazma SOD aktivitesinde artma meydana getirirken karaciğer dokusu XO, MDA ve kas dokusu MDA seviyesinde azalmaya yol açtı. Tükenme egzersizi karaciğer CAT aktivitesinde azalmaya yol açarken plazma CAT aktivitesinin arttığı gözlendi. Spirulina takviyesinin plazma biyokimyasal belirteçlerinde iyileşmeye yol açtığı, ancak gerek plazmada gerekse karaciğer ve iskelet kası dokularındaki oksidatif strese ve antioksidan duruma etkisinin çelişkili olduğu gözlendi. Elde edilen bulguların ışığında, spirulinanın egzersize bağlı oksidatif strese etkinliğinin daha detaylı ve yeni biyobelirteçler kullanılarak tespit edilmesi gerektiği sonucuna ulaşıldı.Öğe Tavşan Diz Eklemi İnsan Elinin Metakarpofalengeal ve Interfalengeal Eklemleri için Uygun Bir Model Midir?(2010) Karalezli, Nazım; Durduran, Savaş S.; Ogün, Tunç C.; Uysal, İsmihan İlknur; Ünver Doğan, Nadire; Öz, MehmetAmac: Bu çalışmada, insan elindeki interfalengeal ve metakarpofalengeal eklemler için küçük eklem modeli olarak tavşan diz ekleminin uygunluğunun incelenmesi amaçlandı. Calışma planı: Farklı insan kadavradan 42 metakarpalin distal eklem yüzey alanı, 90 proksimal falanksın distal ve proksimal eklem yüzey alanı ve 47 orta falanksın proksimal eklem yüzey alanı ile 10 Yeni Zelanda beyaz tavşanının 20 dizinin proksimal tibia ve distal femur eklem yüzey alanları fotogrametrik yöntemle hesaplandı ve karşılaştırıldı. Sonuclar: Tavşan dizi proksimal tibia eklem yüzey alanı ortalaması, orta falanksın proksimal eklem yüzey alanından, proksimal falanksın distal eklem yüzey alanından, proksimal falanksın proksimal eklem yüzey alanından ve metakarpalın distal eklem yüzey alanından daha büyüktü. Tavşan femur distal eklem yüzey alanı ortalaması orta falanksınkinden daha büyük iken, proksimal falanksı n proksimal, metakarpalın distal ve proksimal falanksın distal eklem yüzey alanına benzerdi. Cıkarımlar: Sonuç olarak, tavşan diz eklemi ile insan elinin MP ve iP eklemleri arasında uyum bulunamamıştır. insan elindeki küçük eklemler için uygun bir hayvan modeli ihtiyacı devam etmektedir.
