The comparison of preemptive analgesic effects of curcumin and diclofenac
Küçük Resim Yok
Tarih
2014
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
COMENIUS UNIV
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: Preemptive analgesia is an antinociceptive treatment that prevents central sensitization. Antinociceptive effects of diclofenac are well-known. The aim of this study was to investigate preemptive analgesic effects of curcumin and diclofenac, before acute and inflammatory induced pain in rat model. Material and methods: Fourty eight old female (n = 6 in each group) Wistar Albino rats were included in the study. Paw movements in response to paw flinching in response to formalin injection or thermal stimulation were compared after curcumin (400 mg kg(-1), p.o.) and diclofenac (10 mg kg(-1), i.p.) administration. Saline was used as a control. The solvent ethanol was administered in another group of rats. Preemptive analgesic effect was significant in both tests when curcumin and diclofenac was administrated before the pain stimuli. Results: Oral administration of curcumin and intraperitoneal injection of diclofenac increase the response time in hot plate test and decrease the number of flinches in formalin test (p < 0.001 vs p < 0.05). Conclusion: These results suggest that curcunnin had preemptive analgesic effects on acute thermal, and inflammatory induced pain in rats as diclofenac (Fig. 2, Ref. 35). Text in PDF www.elis.sk.
Açıklama
Anahtar Kelimeler
curcumin, diclofenac, preemptive analgesic effect, rat
Kaynak
BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
115
Sayı
12
