Yazar "Ateşşahin, Ahmet" seçeneğine göre listele
Listeleniyor 1 - 14 / 14
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Amigdalin ile Zehirlenen Koyunların Kobalt Klorür ve Sodyum Tiyosülfat ile Tedavisi(Selçuk Üniversitesi, 1996) Pirinçci, İbrahim; Tanyıldızı, Sadettin; Ateşşahin, Ahmet; Kara, Haki; Özaydın, SongülThe presant experiment was carried out to compare the effects of cobaltous chloride and sodium thiosulfate used in the treatment of sheep poisoned with amygdalin. In the study, changes occuring levels of eyanide in the rumen liquor and levels of cyanide, thiocyanate, hemoglobin and methemoglobin in the blood, were determined. In the study, sixteen ewes, aged approximately two years old, were used. The animal on which the experiment was made was fasted from 5 p.m. a day ago to the complement of experiment the next day, Thus, eyanide contaminations due to feed and water were prevented. Amygdalin was given through the rumen probe in the doses of 1,5 mg/kg. Samples of rumen and blood were collected at 1,2,4,8,24,72. hours after amygdalin was given. Samples of the rumen were analysed in terms of the levels cyanide. Samples of the blood were analysed in terms of the levels cyanide, thiocyanate, hemoglobin and methemoglobin. lt was observed that co b alt chloride given in the dos es of 5,1 O and 15 mg/ kg at thirty minules decreased the level of eyanide from 0,21 O ug/ml to 0.079, 0.039 and 0.068 ug/ml at first hour, respectively. On the other hand, it was defined that sodium thiosulfate given in doses of 50, 400 and 600 mg/kg at thirty minutes decreased the level kof eyanide from 0.21 O ug/ml to 0.139, 0.165 and 0.179 u gl ml at first hour, respectively. lt was established that cobaltous chloride + sodium thiosulfate given in the dose of 10+600 mg/kg at thirty minules decreased the level of eyanide from 0.21 O u gl ml to 0.103 ug/ml at first hour. Cobaltous chloride u sed in the treatment of the eyanide poisoning was found to be more elfactive than sodium thiosulfate.Öğe Amigdalin ile Zehirlenen Koyunların Sodyum Nitrit ve Kobalt Klorür ile Tedavisi(Selçuk Üniversitesi, 1996) Pirinçci, İbrahim; Servi, Kadir; Tanyıldızı, Sadettin; Ateşşahin, Ahmet; Güler, OsmanThe preseni experiment was carried out to compara the etfects of cobaltous chloride and sodium thiosulfate used in the treatment of sheep poisoned with amygdalin. In the study, changes occuring levels of eyanide in the rumen liquor and levels of cyanide, thiocyanate, hemoglobin and methemoglobin in the blood, were determined. In the study, sixteen ewes. aged approximately two years old, were used. The animal on which the experiment was made was fasted from 5 p.m. a day ago to the complement of experiment the next day. Thus, eyanide contaminations due to feed and water were prevented. Amygdalin was given through the rumen probe in the doses of 1,5 mg/kg. Samples of rumen and blood were collected at 1,2,4,8,24, 48 and 72. hours after amygdalin was given. Samples of the rumen were analysed in terms of the levels cyanide. Samples of the blood were analysed in terms of the levels cyanide, thiocyanate, hemoglobin and methemoglobin. lt was observed that sodium nitrite given in the doses of 5,15 and 25 mg/kg at thirty minules decreased the level of eyanide from 0,21 O u gl ml to 0.082, 0.108 and 0.115 u gl ml at first hour, respectively. On the other h and, it was defined that cobatous chloride given in doses of 5, 1 O and 15 mg/kg at thirty minules decreased the level of eyanide from 0.21 O ug/ml to 0.031, 0.037 and 0.056 ug/ml at first hour, respectively. lt was established that cobaltous chloride + sodium nitrit given in the dose of 15+25 mg/kg at thirty minules decreased the level of eyanide from 0.21 O ug/ml to 0.075 ug/ml at first ho ur. Cobaltous chloride used in the treatment of the eyanide poisoning was determined to be more elfactive than sodium nitrit.Öğe Deneysel Olarak Amigdalin ile Zehirlenen Koyunlarda Serum Kalsiyum, Sodyum, Potasyum, Magnezyum ve Bakır Düzeylerinin Belirlenmesi(Selçuk Üniversitesi, 1996) Pirinçci, İbrahim; Tanyıldızı, Saadettin; Karahan, İzzet; Özaydın, Songül; Kara, Haki; Ateşşahin, AhmetThe present experiment was carried out to investigate the changes occuring calcium, sodium, potassium, magnesıum and copper levels ln the blood of the sheep experimantally poisoned with amygdalin. In the study twenty ewes. aged approximately two years old were used. The animal an which the experiment was made was fasted trom 5 p.m. a day ago to the complement of experiment the next day. Thus. eyanide contamlnatıon due to feed and water were prevented Amygdalin was gıven through the rumen probe ın doses of 0.25. 0.5. 1.0. 1.5 mg/kg. Samples of the blood were collected at 1 ,2,4,8,24.48,72. hours alter amygdaline was given. Samples of the blood were analysed in terms of the levels calcium, sodlum, potasstum, magnesium and copper. In conclusion, the levels of sodlum, potassium and calcium were observed to increase experimentally in the eyanide poisoning. On the other hand, the levels of magnesıum and copper were determined to deereasa experimentally in the eyanide poisoning.Öğe Deneysel Olarak Selenyum Zehi?rlenmesi? Oluşturulan Koyunlarda Kan ve Doku Selenyum Düzeyleri?ni?n Beli?rlenmesi?(Selçuk Üniversitesi, 2001 Ocak) Ateşşahin, AhmetThis study was carried out to determine the changes in the selenium levels in blood and tissues in sheep experimentally poisoned with selenium. In the study, 25 Morkaraman sheep at the weight of 50-55 kg were used. Selenium was given orally at the doses of 1, 2, 3 and 4 mg/kg and intramuscularly at the doses of 0.1, 0.2, 0.4 and 0.6 mg/kg. Blood samples were taken from v.jugularis following the oral and intramuscularly application of selenium at 1. 3, 6, 9, 12, 18, 24, 48, 72, 120, 168, 240, 360, 480, 600th hours; and at 10, 20, 30th min, 1, 3, 6, 9, 12, 24, 48, 72. 120, 168, 240th hours, respectively. Selenium was intramuscularly given at the dose of 0.6 mg/kg and then tissue samples were obtained at 1/2, 1, 3, 9 and 24th hours by decapitation of sheep. The blood selenium levels started to increase at 1st hour and observed to reach to the maximum levels at 18th hours in all doses of selenium given orally. Then, the selenium levels were determined to gradually decrease to the near levels of control groups at 360th hours at doses 1 and 2 mg/kg, and 600th hours at doses 3 and 4 mg/kg. The selenium levels of blood samples started to increase in all doses at 10th min following the administration of selenium intramuscularly and reached to the maximum levels at 20th min at the doses of 0.1 and 0.2 mg/kg; and 30th min at doses of 0.4 and 0.6 mg/kg. Then, the blood selenium levels gradually decreased to the near levels of control groups at 120th hours at doses 0.1 and 0.2 mg/kg, 168th hours at doses 0.4 and 0.6 mg/kg. Selenium levels in liver, kidney, spleen, heart, lung. muscle and bile started to increase at 30th min and were observed to reach the maximum levels at 1st hours in spleen, heart and lung; at 3rd hours in liver, kidney and muscle: at 9th hours in bile, following the application of selenium intramuscularly at the doses of 0.6mg/kg. Then, the selenium levels determined to gradually decrease and they were at the higher levels than control groups at 24th hours. No changes were observed in the selenium levels in hair, skin and toenail within the 24 hours.Öğe Deneysel Olarak Üretilen Ton Tipi Aynalı Sazan (Cyprinus Carpio L. ) Konservelerinin Nitrat ve Nitrit Düzeyleri(Selçuk Üniversitesi, 1996) Servi, Kadir; Arslan, Ali; Ateşşahin, Ahmet; Kaya, Aysel; Çelik, CemalThis study was performed to determine varia1ions in nitrate and nitrita levels during storage period in ton type of Mirror carp fish can. Can were produced experimentally and used tour different sauce formula. Sample levels of nitrite and nitrata which stored in refrigerator ( +4°C) were O. 15 ± O. ı 4 - ı. 04 ±O. ı 6 ppm, ı 3. 4 ± O. 2ı - ı 9. 36 ± O. 87 ppm in sauce; also some values were O. ı 8 .1: O. 11 1. 06 ±O. ı4, 10. 96 ±O. 57 15. 38 ±O. 41 ppm In can meat. respectively. lt was observed that there were signiflcant differences in nitrate levels between every group of can sample for both sauce and can meat. also between tour groups of can for both sauce and can meat at 6th. 12lh and 24th months of storage (p< O. 05). The result of statistical analysis of nitrita level significant dillerence between every group of can sample for both sauce and can meat wereı observed. Also. there were signHicant differences, at 12lh month for sa uc e and at 6th, ı 2th month for can meat between can groups (p< O. 05). In conclusion, it was observed that ton type of Mirror carp cans prepared by using dHferent sauces formula and stored in refrigerator condition meets the quality standarts required for consumer health for each sauce formula.Öğe Effect of Lycopene on Caspase-3 Enzyme Activation in Liver of Methanol-Intoxicated Rats: Comparison with Fomepizole(MARY ANN LIEBERT INC, 2010) Kurçer, Mehmet Ali; Kurçer, Zehra; Köksal, Mete; Baba, Füsun; Ocak, Ali Rıza; Aksoy, Nurten; Ateşşahin, Ahmet; Sahna, EnginLycopene is one of the major carotenoids and is found almost exclusively in tomatoes and tomato products. This study was performed to evaluate the effect of lycopene on methanol-induced liver injury and to compare the results with those after fomepizole, which is used in treatment of methanol intoxication. Experiments were carried out with 30 female Wistar rats weighting 180-200 g. Rats were injected with a intraperitoneally dose of 3 g/kg methanol as a 50% solution in isotonic saline once for intoxication. Rats were pretreated with fomepizole (50 mg/kg) and/or lycopene (10 mg/kg) before methanol. After 24 hours all the drug-treated and intoxicated rats were sacrificed under anesthesia. Malondialdehyde (MDA) levels were determined in order to assess lipid peroxidation, and caspase-3 activity was determined by immunostaining of liver tissues to evaluate apoptosis. Methanol administration significantly increased the MDA level and caspase-3 activity in liver. Pretreatment with lycopene and/or fomepizole decreased the MDA levels significantly. Similarly, lycopene and fomepizole decreased methanol-induced caspase-3 activity. The findings of the present study demonstrate that methanol intoxication causes hepatic toxicity in rats and that this is likely a result of reactive oxygen species and apoptosis induction. Lycopene has protective effects against methanol-induced hepatic injury similar to fomepizole. It was demonstrated for the first time that both lycopene and fomepizole prevent methanol-induced hepatic injury by reducing the increase of lipid oxidation and caspase-3 activation.Öğe Effects of 3-Aminobenzamide on Unilateral Testicular Ischemia-Reperfusion Injury: What is the Role of PARP Inhibition?(CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS, 2010) Hekimoğlu, Aşkın; Kurçer, Zehra; Aral, Faruk; Baba, Füsun; Ateşşahin, Ahmet; Sakin, FatihOn a examine´ les effets the´rapeutiques de l’inhibition de la poly(ade´nosine diphosphate-ribose) polyme´rase par le 3-aminobenzamide (3-AB) dans une le´sion d’ische´mie-reperfusion (I/R) des testicules en utilisant une analyse de sperme. On a effectue´ des examens histopathologiques et biochimiques pour mesurer les activite´s de la superoxyde dismutase (SOD), de la catalase (CAT), de la glutathion peroxydase (GSH-Px), et les taux de glutathion (GSH) re´duit. On a divise´ des rats maˆles en 3 groupes : ayant subi une ope´ration factice (sham) (n = 12), I/R (n = 12) et I/R avec 3AB (I/R–3- AB) (n = 12). On a occlus l’arte`re testiculaire gauche pendant 1 h, puis on l’a soumis a` une reperfusion pendant 24 h (pour les examens biochimiques et histopathologiques) et 30 jours (pour l’analyse de sperme). L’administration de 3-AB par voie intrape´ritone´ale 10 min avant et 1 h apre`s la reperfusion a augmente´ la diminution induite par l’I/R de la motilite´ du sperme dans les 2 testicules, et elle a diminue´ l’augmentation anormale des taux de sperme dans le testicule ipsilate´ral. Toutefois, le traitement par 3-AB n’a pu pre´venir la diminution induite par l’I/R du taux de sperme dans les 2 testicules. Les activite´s de SOD et de CAT sont demeure´es stables chez tous les groupes. L’I/R a augmente´ l’activite´ de la GSH-Px et les taux de GSH. Le traitement par 3-AB a renverse´ l’augmentation induite par l’I/R de l’activite´ de la GSH-Px comme chez les sham, mais il n’a pas modifie´ les taux de GSH. Le traitement par 3-AB a augmente´ de manie`re significative la diminution induite par l’I/R du score histopathologique. En conclusion, un traitement par 3-AB offre des avantages biochimiques et histopathologiques potentiels au-dela` de la qualite´ du sperme et pourrait diminuer l’alte´ration de la torsion testiculaire.Öğe Farklı Dozlarda İndometasi?n Uygulanan Ratlarda Bazı Bi?yoki?myasal Değerleri?n Beli?rlenmesi?(Selçuk Üniversitesi, 2000) Karahan, İzzet; Pirinçci, İbrahim; Elitok, Bülent; Ateşşahin, AhmetThis study was carried out to investigate the changes occurring in the levels of serum aspartate tran- saminase (AST), alanine transaminase (ALT), gamma glutamyl transpeptidase (GGT), alkaline phosphatase (ALP). lactic dehydrogenase (LDH), creatin phosphokinase (CPK), sorbitol dehydrogenase (SDH), total bilirubin (TB), direct bilirubin (DB), total protein (TP), albumin (ALB), triglyceride (TG), glucose (GL) and osmolality (OSM) in rats given with three different doses of indomethacin. As materials, eighty-four rats were used. Indomethacin was given int- ramuscularly at the doses of 2.5, 5.0 and 7.5 mg/kg. The blood samples were collected at 0.5, 1, 2, 4, 8, 12 and 24th hours. These samples were analysed for the biochemical parameters. In conclusion, it was determined that in- domethacin increased the levels of AST, ALT, GGT, ALP LDH, CPK, SDH, TB, DB, GL and OSM in serum of rats ex- perimentally given the different doses of indomethacin. In contrast, indomethacin was established to decrease the levels of TP, ALB and TG in serum of rats.Öğe Koyunlarda Selenyum Zehi?rlenmesi?ni?n Tedavi?si? Üzeri?ne Deneysel Çalışmalar(Selçuk Üniversitesi, 2000) Pirinçci, İbrahim; Ateşşahin, Ahmet; Karahan, İzzetThis study was carried out to compare the sole and combine effects of cysteine, methionine, cobalt chlonde, sodium thiosulphate and sodium nitrite used in the treatment of sheep poisoned with selenium. In the investigation, the changes occurred in the levels of selenium in the blood samples were determined. In the experiments, 66 sheep, at the age of approximately two years were used. The animals on which the experiments were made were fasted from 5.00 pm a day ago to the complement of experimental the next day. Thus, selenium contamination due to feed and water as prevented. Selenium was intramuscularly given at the dose of 0.6mg/kg Cysteine, methionine, cobalt chloride, sodium thiosulphate and sodium nitrite were given 30th min before the intravenous selenium administration. Cysteine, methionine, cobalt cloride, sodium thiosulphate and sodium nitrite decreased the levels of selenium in the blood from 2.63 ppm to 1.82, 1.76, 2.14, 1.70 and 2.03 ppm in 30th min, respectively. On the other hand, cysteine+methionine, cysteine+cobalt chloride, methionine+cobalt chloride, cysteine+methionine+cobalt chloride and sodium thiosulphate-sodium nitrite decreased the levels of selenium in the blood from 2.63 ppm to 1.21 121, 1.68 1.24 and 1.79 ppm in 30thmin, respectively. In conclusion, cysteine+methionine +cobalt cloride and other combinations used in the treatment of selenium poisoning were found to be more effective than cysteine, methionine. cobalt cloride, sodium, thiosulphate and nitrite.Öğe Koyunlarda Si?yanojenik Gli?kozi?tlerle Zehi?rlenmeler Üzeri?ne Deneysel Çalışmalar(Selçuk Üniversitesi, 1997 Ocak) Pirinçci, İbrahim; Tanyıldızı, Sadettin; Özaydın, Songül; Kara, Haki; Ateşşahin, AhmetThe present experiment was made to determinate the changes in the cyanide levels of rumen liquor and the cyanide, thiocyanate, hemoglobin ve methemoglobin levels in blood of the sheep experimentally poisoned with amygdalin. Amygdalin was given in the doses of 0.25, 0.5, 1 and 1.5 mg/kg through rumen probe. An increase was observed in the cyanide levels of rumen and the cyanide and thiocyanate levels of blood after 30, minutes. Blood cya. nide levels arrived maximum at first hour in the all doses of amygdalin (0.25, 0.5, 1 and 1.5 mg/kg). Blood thiocyanate levels reached maximum at first hour in the amount of 0.25 and 0.5 mg/kg and at second hour in the amount of 1 and 1.5 mg/kg after dosing. The cyanide and thiocyanate levels gradually reduced and then decreased the near levels of control groups at 72. hours. The hemoglobin and methemoglobin levels in blood didn't show importantly changes.Öğe Selenyum Veri?len Farelerde Kan ve Dokulardaki? Selenyum Düzeyleri?ni?n Beli?rlenmesi?(Selçuk Üniversitesi, 2000) Pirinçci, İbrahim; Karahan, İzzet; Demirbaş, İrfan; Ateşşahin, AhmetIn this study, the selenium levels in the blood and tissue samples of mice experimentally poisoned with selenium were investigated. In the investigation, 210 mice were used. The blood and tissue samples were taken at 5, 10, 15, 30th min, 1, 2, 4, 8, 24, 48 and 72th hours following the intraperitoneal administration of selenium at the doses of 1 and 2 mg/kg. Similarly, the blood and tissue samples were taken at 30, 60 and 90th days following the oral ad- ministration of selenium at doses of 0.5, 3 and 10 ppm. The selenium levels in the samples were spect- rophotometrically measured at 420 nm. In conclusion, the selenium levels were determined to increase depending on time and dose in mice treated with selenium orally. Whereas, when it was intraperitoneally given, the selenium levers were defined to reach to the maximum levels in blood at 10 and 30th min; in liver at 30th min and 2 nd hours; in kid- ney at 1st hour, in spleen at 15 and 30th min; in heart at 10 and 15th min; in muscle at 24 and 8th hours according to doses, respectively. Afterwards, the selenium levels were established to decrease, gradually.Öğe Selenyumun Koyunlarda Bazı Bi?yoki?myasal Parametreler Üzeri?ne Etki?leri?ni?n Araştırılması(Selçuk Üniversitesi, 2001 Nisan) Pirinçci, İbrahim; Ateşşahin, Ahmet; Elitok, BülentBu çalışma, deneysel olarak selenyum zehirlenmesi oluşturulan koyunlarda serum aspartat transaminaz (AST), alanin transaminaz (ALT), g-glutamil transpeptidaz (GGT), alkalin fosfataz (ALP), laktik dehidrojenaz (LDH), kreatin fosfokinaz (CPK), total bilirubin (TB), direk bilirubin (DB), total protein (TP), trigliserid, albümin ve glikoz düzeylerinde meydana gelen değişiklikleri belirlemek amacıyla yapıldı. Araştırmada ağırlıklan 50-55 kg arasında 18 adet koyun kullanıldı. Selenyum kas içi yolla 0.2 ve 0.6 mg/kg dozlarında verildi. Kan ömekleri 0.5, 1, 3, 6, 12, 24, 48, 72, 120 ve 240. saatlerde alındı ve bu ömekler AST, ALT, GGT, ALP, LDH, CPK, TB, DB TP, trigliserid, albümin ve glikoz yönünden incelendi. Sonuç olarak, deneysel yolla oluşturulan selenyum zehirlenmesinde selenyumun koyunların serum AST, ALT, LDH, CPK, TB, DB ve TP düzeylerini artırdığı, buna karşılık glikoz düzeylerini ise azalttığı belirlendi.Öğe Sodyum Nitroprussit Veri?len Farelerde Dokulardaki? Si?yanür ve Ti?yosi?yanat Düzeyleri?ni?n Beli?rlenmesi?(Selçuk Üniversitesi, 1997 Ocak) Pirinçci, İbrahim; Tanyıldızı, Sadettin; Ateşşahin, Ahmet; Kara, Haki; Özaydın, SongülIn this study, cyanide and thiocyanate levels at liver. spleen, kidney and muscle tissue samples obtained from mice which were given different doses sodium nitroprusside (SNP) were investigated. The cyanide and thiocyanate levels in the samples were colorimetrically determined the oxidation of cyanide and thiocyanate by bromine water and coupling of pyridine benzidine reagents. Absorbances were measured at 532 nm. The cyanide and thi ocyanate levels in tissue samples increased after 12 h. and arrived the maximum levels at the different times according to doses. Then the cyanide and thiocyanate levels in samples decreased the same levels with control groups at 192 h.Öğe Sodyum Nitroprussit Veri?len Farelerde Kan ve I?drardaki? Si?yanür ve Ti?yosiyanat Düzeyleri?ni?n Beli?rlenmesi?(Selçuk Üniversitesi, 1995 Nisan) Pirinçci, İbrahim; Tanyıldızı, Sadettin; Ateşşahin, Ahmet; Özaydın, SongülIn this study, cyanide and thiocyanate levels in blood and ürine samples optained from mice which were injected different doses sodium nitroprusside, were determined. The cyanide and thiocyanate levels in the blood and ürine samples were colorimetrically established oxidation of cyanide and thiocyanate by bromine water and coupling of pyridine-benzidine solution. The cyanide levels in blood and ürine respectively, arrived the maximum levels at 40 min. and 8 h. The thiocyanate levels in ürine of this animals arrived the maximum levels at 48 h. The thiocyanate levels decreased at the small portion after 96 h. and were the same levels for several days. The thiocyanate levels in blood arrived the maximum levels at 80 min and were the same levels for several days.
