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Öğe A Case of Ventricular Flutter and Fibrillation in a Calf Suffering from Diarrhea(Selçuk Üniversitesi, 1989 Ocak) Başoğlu, Abdullah; Turgut, KürşatÜç gündür ishal şikayeti olan bir buzağının çekilen elektrokardiyografisinde ventriküler flatter ve fibrilasyon teşhis edildi. Buzağıda dehidrasyonla birlikte aşırı zayıflama vardı ve klinik tablo çok ağırdı. Hematolojik muayenede; hiperkalemi (12.5 mEq/L) ve hiperkloremi (159 mEq/L) tesbit edildi. Serum Na+ (156 mEq/L) ve Ca++ (10.43 mg/dl) konsantrasyonları normal sınırlar içindeydi. Buzağı kliniğe getirildikten otuz dakika sonra öldü. Otopside, kalpte herhangi bir organik bozukluğa rastlanmadı.Öğe The Clinical-Chemical Parameters, Serum Lipoproteins and Fatty Infiltration of the Liver in Ketotic Cows(SCIENTIFIC TECHNICAL RESEARCH COUNCIL TURKEY-TUBITAK, 1998) Sevinç, Mutlu; Başoğlu, Abdullah; Öztok, İsmail; Sandıkçı, Mustafa; Birdane, FatihThe objective of this study was to provide a unique insight into the relationship between ketosis and fat cow syndrome using clinical-chemical parameters, serum lipoproteins and histopathological changes of the liver. The cholesterol and protein concentrations were significantly lower in the ketotic cows (p<0.05) than in the controls. The glucose and HDL-cholesterol levels were significantly lower in the ketotic cows (p<0.01) than controls. The total bilirubin, CPK levels (p<0.05), and direct bilirubin, albumin levels (p<0.01) were significantly higher in the than controls. The percentage of fatty in filtration of the liver parenchyma varied from 27 to 42 percent in seven ketotic caws and was 13 per cent in one ketotic cow, in light of this a relationship was established between postpartum clinical ketosis and fat cow syndrome.Öğe Effect Of Acute Ruminal Acidosis On Riboflavin and Niacin Concentrations In Sheep(Selçuk Üniversitesi, 1993) Başoğlu, Abdullah; Turgut, Kürşat; Eksen, Mursayettin; Traş, Bünyamin; Maden, Mehmet; Ok, Mahmut; Baş, A. Levent; Keçeci, TufanSix nonlactating, nonpregnant adult ewes divided into two groups of 3 animals each as a control and experimental groups were used to evaluate the effect of experimentally induced acute ruminal acidosis on plasma and rumen fluid riboflavin and niacin concentrations. Decreasements in ruminal fluid pH, the count of protozoa and increase in the count of bacteria were related to gradual decreases in plasma riboflavin and niacin concentration. Plasma riboflavin and niacin concentrations decreased respectively from 9.51 mcg/ ml and 7 01 mcg/ml to 0.42 mcg/ml and 0.09mcg / m * l at the first day of the experiment (p < 0.05) and than inclined towards normal values. Similar drastical decrease in the niacin concentration of rumen fluid was determined at the first day of the experiment.Öğe Effect of Phlorhizin-Induced Ketosis on Riboflavin and Niacin Levels in Sheep(Selçuk Üniversitesi, 1993 Ocak) Başoğlu, Abdullah; Turgut, Kürşat; Eksen, Mursayettin; Traş, Bünyamin; Maden, Mehmet; Ok, Mahmut; Baş, A. Levent; Keskin, ErcanSix non-lactating, non-pregnant adult ewes divided into two groups of 3 animal each as a control and experimental groups were used to evaluate the effect of phlorhizin-induced ketosis on plasma and rumen fluid riboflavin and niacin concentrations. The mean pH values and the counts of protozoa and bacteria of the rumen fluid in experimental group did not change significantly (p > 0.05) Alteration of plasma riboflavin concentration in experimental group was not significant (p > 0.05) . Whereas both plasma and rumen fluid niacin concentrations decreased from 5.03mcg / m * l and 9.53 mcg / m * l to 2.39mcg / m * l and 2.41 mcg/ml respectively and decraements in both plasma and rumen fluid niacin concentrations were significant (p<0.05).Öğe Effects of Long-Term Boron Administrations on High-Energy Diet-Induced Obesity in Rabbits: NMR-Based Metabonomic Evaluation(MEDWELL ONLINE, 2011) Başoğlu, Abdullah; Başpınar, Nuri; Öztürk, Aliye Sağkan; Akalın, Pınar PekerThe aim of this study is to provide insight into boron metabolism and to identify metabolic pathways which may explain the presumed increased susceptibility of livers. Boron was administrated in rabbits at three different doses and 96 h intervals for 7 months. Metabolomic profile based on NMR analysis was performed. The most pronounced findings were significant changes in alanine, methionine, pyruvate and creatine. Boron seems to be effective in the prevention of obesity and fatty liver. Metabolic end-points obtained by NMR can be easily assessed and interpreted alone or in. combination each other and with classical biochemical parameters for better understanding obesity and boron and liver metabolism.Öğe Efficacy of Sodium Borate in the Prevention of Fatty Liver in Dairy Cows(Amer Coll Veterinary Internal Medicine, 2002) Başoğlu, Abdullah; Sevinç, Mutlu; Birdane, Fatih Mehmet; Boydak, MuratThe effects of sodium borate (100 mg/kg body weight, PO, 15 days) from a month before expected calving until a month after calving were evaluated in dairy cows susceptible to fatty liver. Cows received either sodium borate (n = 13) or no treatment (n = 10). All cows had mild fatty livers and increased plasma triglycerides and very low density lipoprotein (VLDL) concentrations at the beginning of the experiment. The control group of cows developed significant fatty liver after calving, and 2 of them had severe fatty liver associated with clinical and biochemical abnormalities. There were no clinicopathological signs related to sodium borate administration. Serum triglycerides and VLDL concentrations before calving decreased significantly at calving and after calving in controls, and they were within the normal range only after calving. There were significant alterations during the experiment in some hematological and chemical variables between groups, within period, but they were within the normal range. Unlike treated cows, serum triglycerides and VLDL concentrations correlated with liver fat content after calving in untreated cows. Our results document that sodium berate decreases the degree of fatty liver in dairy cows during early lactation.Öğe Electrocardiographic Studies in Brown Swiss Cows(Selçuk Üniversitesi, 1992 Ocak) Başoğlu, Abdullah; Turgut, Kürşat; Ok, Mahmut; Kadak, RamazanYaşları dört ile sekiz arasında değişen toplam 43 adet sağlıklı İsviçre Esmer ırkı sığırda elektrokardiyografik parametreler ölçüldü, hesaplandı ve analizleri yapıldı. Elektrokardiyogramlar bipolar ekstremite, yükseltilmiş ünipolar ekstremite ve ünipolar prekordiyal darivasyonlar kullanılarak bir kanallı, taşınabilir elektrokardiyografa kaydedildi. Elektrokardiyograf her 1 mv için 20 mm. 'ye kalibre edildi ve kağıt hızı 25 mm/sn olarak ayarlandı. Elektrokardiyogramlar her sığırda 15 gün içinde iki kez, sabah yemlemesinden sonra kaydedildi. P, QRS, T dalgaları ve PQ, QT ST aralıklarının süreleriyle P, QRS, T dalgalarının amplitüdleri ölçüldü. Çalışmanın sonucunda bipolar ekstremite, arttırılmış ünipolar ekstremite ve ünipolar gögüs derivasyonu kayıtlarının, hayvandan hayvana ve aynı hayvanda farklı zamanlarda değiştiği gözlendi.Öğe Fatty Liver in Periparturient Diseases of Dairy Cows(Indian Veterinary Journal, 2002) Sevinç, Mutlu; Başoğlu, Abdullah; Ok, Mahmut[Abstract not Available]Öğe İneklerde Kalsiyum Enfüzyonlarına Bağlı Kalp Aritmilerinin Önlenmesinde Atropin ve Verapamil'in Etkileri Üzerine Araştırmlar(Selçuk Üniversitesi, 1990 Ocak) Başoğlu, Abdullah; Turgut, Kürşat; Dinç, D. Ali; Ok, Mahmut; Maden, MehmetCette étude a été effectuée sur 6 vaches sains. Dans le premier etape, la solution de calcium nommé Surcalce a été injectée à chaque animal. Cinq minutes avant la même injection, Verapamil aussi, dans le troissième etape, ont été utilisés. Avant d'administrer et 1 et 30 minutes après avoir administré la solution de calcium, on mesuré le niveau de calcium du serum. Au cours de ces applications, dans le premier etape, on a fixé sinus arret chez 4 vaches, SA et AV bloc chez une vache, paroxysmale tachicardie ventriculaiere chez une vache. En conséquence, en utilisant Atropin et Verapamil ces arythmies de coeur ont été empechées.Öğe Köpeklerde Akut Di?goksi?n Toksi?kasyonunda Kolesti?rami?n'i?n Etki?si?(Selçuk Üniversitesi, 1993) Başoğlu, Abdullah; Maden, Mehmet; Çiftçi, Kemal; Akkuş, İdris; Koçyiğit, Abdurrahim; Hatipoğlu, Fatih; Akbulut, HüseyinIn this study, the effects of cholestyramine on the clinical, laboratory and histopathologic findings in dogs with acute digoxin toxicosis was induced by intravenouse injection of digoxin at the dose of 0.1 mg/kg in two groups of dogs (control and experimental groups) and clinical pathologic, histopathologic and electrocardiographic findigs and changes in serum digoxin concentrations were evaluated. Incriments in red blood cell count (RBC), blood urea nitrogen (BUN) and serum uric acide. Potassium and digoxin concentrations and decreaments in serum sodium and chlorid concentrations were found to be significant in control group of dogs while changes in this parameters were not found to be significant in experimental group of dogs treated with cholestyramine. At the histopathologic examinataions of both groups of dogs, the pathologic lesions in coroner arteries, myocardium and kidneys in control group of dogs were more severe than that of experimental group of dogs and a dog in control group died during the experiment. The result of the study showed that acute digoxin toxicosis caused significant changes clinical pathologic and histopathologic significant changes, clinical pathologic and histopathologic findings and the treatment of acute digoxin toxicosis with cholestyramine would be benefical in dogs.Öğe Köpeklerde Di?rofi?lari?a I?mmi?ti?s'i?n Sağıtımında Levami?zol ve I?vermecti?n'i?n Etki?leri?(Selçuk Üniversitesi, 1992 Mart) Dik, Bilal; Başoğlu, Abdullah; Kaya, MuttalipThis study was conducted to evaluated the effectiveness of levamisole and ivermectin in the treatment of Dirofilaria immitis. For this purpose, 14 dogs suffering from Dirofilaria immitis were used as a material. At the clinical examination of dogs, all were found to be listless. They were divided into two groups. Levamisole (2.5 mg/kg, orally) was given to the first group for 14 days. And it was repeated after 15 days at the dose of 5 mg/kg. At the sixth week of experiment, ivermectin (0.2 mg/kg, orally) was given to treatment group for 5 days. Second group was kept as a control. At the end of Levamisole treatment, microfilariae were found in the blood of seven dogs of treatment group. Wherease microfilariae were absent in three dogs. However, at the end of ivermectin treatment, blood examination showed that there was no microfilariae in blood of all dogs of treatment group. The result of this study showed that, Ivermectin was more effective than Levamisole on the microfilariae of Dirofilaria immitisÖğe Koyunlarda Ventral Trunkal Vagotominin Ön Mideler ve Abomasum Fonksiyonları Üzerine Etkileri(Selçuk Üniversitesi, 1990 Ocak) Turgut, Kürşat; Başoğlu, Abdullah; Koç, Yılmaz; Çiftçi, Kemal; Tıpırdamaz, Saadettin; Aslan, Veysi; Gürbilek, Mehmet; Ok, Mahmut; Özkan, CevatIn this study, a total of 12 sheep was used. 6 of which were used as a control group on which only paramedian laparatomy was performed. 6 of which were used as an experimental group on wihch ventral truncal vagotomy was performed via paramedian laparatoy. All the clinical, heamotological, biochemical and electrocardiographic examinations were performed for a month during the experiment. During the study clinical symptoms of vagus indigestion which has been described by Hoflund were not observed. There was significant decreaments in the respiration rate of experimental group at the 4 ^ (th), 10 ^ (th) and 20th day of the experiment. Plasma BE values were significantly increased at the 10 ^ (th) 20 ^ (th) and 30 ^ (th) day of axperiment in the experimental group. Rumen Cl concentration was significantly increased only at the 15 ^ (th) day of the experiment in the experimental group. Plasma gastrin concentration was decreased only at the sceond day of the experiment in the experimental group. Sinus arret was recorded during the electrocardiographic examination of the two groups of sheep at the diferent time. Theresult of the study showed that functional disorders of the nervus vagus did not play a role of the pathogenesis of vagus indigestion.Öğe Lipid and Lipoprotein Levels in Dairy Cows With Fatty Liver(Scientific Technical Research Council Turkey, 2003) Sevinç, Mutlu; Başoğlu, Abdullah; Güzelbektaş, Hasan; Boydak, MuratThe purpose of this investigation was to establish whether there were any differences in the lipid and lipoprotein levels of dairy cows with fatty liver. Fifty-four dairy cows with fatty liver and 12 healthy dairy cows were used in the study. The liver fat content was determined in all cows histologically. Cows with fatty liver (n = 54) were grouped according to liver fat content as cows with mild (n = 17), moderate (n = 17) or severe(n = 20) fatty liver. Fat infiltration in the liver was not observed in the healthy group of cows. Some serum chemical parameters including albumin, triglyceride, total cholesterol, high-density lipoprotein, and low-density lipoprotein levels were measured in all the cows. Very low-density lipoprotein levels were calculated by the following formula: triglyceride/5. There was a significant decrease (p = 0.000; p = 0.005; p = 0.011, respectively) in albumin, total cholesterol and low-density lipoprotein levels in cows with moderate and severe fatty liver, while triglyceride and very low-density lipoprotein levels were significantly lower (p = 0.000) in all the fatty liver groups. High-density lipoprotein levels were significantly lower (p = 0.028) in cows with moderate fatty liver. There was a significant negative correlation between the degree of fat infiltration and other parameters except for high-density lipoproteins. In conclusion, notable changes in lipid and lipoprotein levels were determined in cows with moderate and severe fatty liver.Öğe Liver Function in Dairy Cows With Abomasal Displacement(ECOLE NATIONALE VETERINAIRE TOULOUSE, 2002) Sevinç, Mutlu; Ok, Mahmut; Başoğlu, AbdullahThe aim of this study was to establish the changes that [nay occur in liver function in dairy cows with abomasal displacement. The liver biopsies from cows with abomasal displacement had 31.5+/-6.1 % fat infiltration. Some chemical parameters (bile acid, glucose, total protein, urea, albumin, globulin, total bilirubin, direct bilirubin, indirect bilirubin, AST, ALT, GGT, CK, triglyceride, total cholesterol, HDL-cholesterol, LDL-cholesterol, VLDL-cholesterol) were measured. Serum AST (p<0.01) and GGT (p<0.001) levels were significantly increased, and HDL-cholesterol (p<0.001) significantly decreased in cows with abomasal displacement compared to healthy cows. There were significant alterations in urea, total protein, albumin, total cholesterol, total bilirubin and indirect bilirubin concentrations, but they were within normal range limits in the same animals. In conclusion, GGT and AST concentrations, and liver biopsy seem to be helpful in the assessment of liver function in cows with abomasal displacement.Öğe Microbiological Examination of the Tracheal Flushing Sample and its Clinical Importance(Selçuk Üniversitesi, 1989 Ocak) Turgut, Kürşat; Erganiş, Osman; Başoğlu, Abdullah; Çorlu, Mehmet; Ok, MahmutSelçuk Üniversitesi Veteriner Fakültesi İç Hastalıklar Kliniğine getirilen 25 buzağıdan mikrobiyolojik muayene için burun sıvabı ve trakeal yıkama örnekleri alındı. Burundan alınan örneklerin 22'sinden çeşitli mikroorganizmalar izole edilirken, trakeal yıkama örneklerinden P. pneumonia (% 40), Staph. aureus (% 20), Klebsiell ssp. (% 13.3), Corynebacterium ssp. (% 6.6), Shigella ssp. (% 6.6), Ps. maltophila (% 6.6), Aspergillus ssp. (% 6.6) saf olarak izole edildi. Etken izolasyonu yapılamayan buzağıların 7'sine önceden değişik antibiyotikler uygulanmıştı. Onbir vakada Linko-spektin (% 47), 9 vakada Gentamisin (% 39) etkili bulundu. Aspergillus ssp. izole edilen bir buzağı Thiabendazole ile tedavi edildi. Bir buzağı tedavi edilemedi. Bu buzağının otopsisinde mikrobiyolojik ve patolojik olarak Tüberküloz olduğu teşhis edildi. Diğer 3 buzağı geniş spektrumlu antibiyotiklerle tedavi edildi. Çalışmanın sonucunda, trakeal yıkama metodunun enfeksiyöz buzağı pneumonilerinin teşhis ve tedavilerinde kolaylıkla ve güvenilir bir şekilde uygulanabileceği kanısına varıldı.Öğe Neonatal I?shalli Buzağılarda Serum Immunoglobuli?nleri?n Glutaraldehid Koagulasyon Testi? ile Değerlendi?ri?lmesi?(Selçuk Üniversitesi, 2000) Şen, İsmail; Başoğlu, Abdullah; Ok, Mahmut; Güzelbektaş, Hasan; Civelek, Turan; Birdane, Fatih M.The aim of this study in neonatal calves, to carry out the relationship between diarrhea and passive colostral transfer and the safety of GA test using SRID (Single Radial Immunodiffussion) test for its determination In this study, healty 20 and diarrheic 30, totally 50 calves were used as a material Serum immunglobulin levels were me asured by GA test as semiquantitative and by SRID test as kantitative. In the some diarrheic calves IgG levels were 250-400 mg/dl and their serum incougulated in 30 minutes In the meantime IgG levels of other diarrhoeic calves were 580-800 mg/dl and their serum semisolid Gelous) at between 12-28 minutes. In the healty calves serum samples with IgG level of 2400-5800 mg/dl coagulated in 1-5 minutes and serum samples with IgG level of 1600 mg/ di coagulated in 6 to 7 minutes. As a result, it could be said that diarrhea is connected with passive colostral transfer and calves with negative and jelous GA test have failure of passive colostral transfer and calves with positive GA test have adequate passive colostral transferÖğe Neonatal ishalli buzağılarda serum immunoglobulinlerin glutaraldehit koagulasyon testi ile değerlendirilmesi(2000) Şen, İsmail; Başoğlu, Abdullah; Ok, Mahmut; Birdane, Fatih M.; Güzelbektaş, Hasan; Civelek, TuranBu çalışmada, neonatal buzağılarda ishalin pasif immun transferi ile ilgisi ve bunu belirlemede glutaraldehid (GA) koagulasyon testinin güvenirliliğinin, bir kantitatif test olan single radial immunodiffüzyon (SRID) testi kullanarak ortaya konulması amaçlanmıştır. Bu araştırmanın materyalini, 20 sağlıklı ve 30 ishalli olmak üzere toplam 50 adet neonatal buzağı oluşturdu, immunglobulin G seviyeleri, kantitatif olarak single radial immunodiffüzyon testi ile; semikantitatif olarakta glutaraldehid koagulasyon testi ile ölçüldü. Neonatal ishalli buzağılarda 30 dakikada pıhtılaşmayan serum örneklerinde IgG konsantrasyonları 250-400 mg/dl iken, 12-28. dakikada yarı pıhtılaşma (jelöz) gösteren serum örneklerinde ise IgG konsantrasyonları 580-800 mg/dl idi. Sağlıklı neonatal buzağılarda 1-5 dakikada pıhtılaşan serum örneklerinde IgG konsantrasyonları 2400-5800 mg/dl iken, 6-7 dakikada pıhtılaşan serum örneklerinde IgG konsantrasyonları 1600-1700 mg/dl idi. Sonuç olarak negatif ve jelöz glutaraldehid test sonucu veren buzağılarda yetersiz pasif kolostral transfere pozitif glutaraldehid test sonucu veren buzağılarda yeterli pasif kolostral transfer gözlenebileceği söylenebilirÖğe Peri and Postparturient Concentrations of Lipid Lipoprotein Insulin and Glucose in Normal Dairy Cows(SCIENTIFIC TECHNICAL RESEARCH COUNCIL TURKEY, 1998) Başoğlu, Abdullah; Sevinç, Mutlu; Ok, Mahmut; Gökçen, MurselIn order to provide uniqe insight into the metabolic disturbences seen after calving cholesterol, triglycerid, high density lipoprotein, low density lipoprotein, very low density lipoprotein, glucose and insulin levels in serum were studied before calving (group I), in aerly (group II) and late (group III) lactation in 24 normal cows. Serum lipoproteins were separeted into various density classes by repeated ultracentrifugation. The results indicate that there was a rise in glucose, tryglycerid and very low density lipoprotein levels before calving, and in cholesterol and high density lipoprotein levels late lactation, and the dairy cows were inclined fatty liver because of lower very low density lipoprotein and glucose levels in early and late lactation, and were inclined hyperketonemia in early lactation because of lower insulin level than in late lactation.Öğe Plasma Transfusion in Calves with Failure of Passive Colostral Transfer(SCIENTIFIC TECHNICAL RESEARCH COUNCIL TURKEY, 1998) Turgut, Kürşat; Başoğlu, Abdullah; Sevinç, Mutlu; Şen, İsmail; Yıldız, Metin; Kaleli, SüleymanPlasma administration was studied in newborn calves with failure of passive colostral transfer (FPCT). Eighteen sick Holstein calves with FPCT (Experimental group) and 6 healthy Holstein calves known to have consumed colostrum (Control group) were used as a materials, Failure of passive colostral transfer was confirmed by a negative gluteraldehyde coagulation test (GACT). Calves with FPCT were weighed on presentation and were randomly divided in to three groups (each group consisted of 6 carves) in those treatment was designed as follows: Experimental group I (EG I) carves were treated with antimicrobials, fluids, various supportive measures, and plasma transfusion was given at the dose of 30 ml/kg body weight, Experimental group ii (EG II) calves were treated with antimicrobials, fluids, various supportive measures, and plasma transfusion was given at the dose of 40 ml/kg body weight. Experimental group III (EG iii) calves were treated with antimicrobials, fluids and various supportive measures. The mean concentrations of serum total protein were significantly greater in calves of control group as compared to calves of EGI, EGII and EGIII (p<0.05). The mean concentrations of serum total protein significantly increased in calves of EGI and EGII after the treatment (p<0.05). The mean concentrations of ail serum protein fractions except beta-globulin fraction were significantly greater in calves of control group as compared to calves of EGI, EGII and EGIII (p<0.05), Calves administered plasma at the dose of 40 ml/kg body weight, I.V. (EGII) showed increased serum alpha-globulin and gamma-globulin concentrations. Serum albumin and beta-globulin fractions were not influenced by plasma administration (p>0.05). The result of the study showed that plasma transfusion at the dose of 40 ml/kg body weight could restore protective levels of Ig and could provide considerable recovery in calves with severe FPCT.Öğe Post Partum Dönem Hastalıklarının Yağlı Karaci?ğer Sendromu ile I?lgi?si?(Selçuk Üniversitesi, 1988 Ocak) Aslan, Veysi; Aştı, Reşat; Nizamlıoğlu, Mehmet; Tekeli, Tevfik; Başoğlu, Abdullah; Demirci, ÜlkerIn this study, a total of 43 heads of cow were used. Some diseases and disorders such as retained placenta, ketosis, metritis, mastitis, hypocalcemia, indigestion and abomasal displacement were diagnosed in these cows. After clinical examination, the blood and liver biopsy samples were obtained. Glucose, GOT, FFA and total lipid values of blood samples and liver fat were measured. In the cases of retention, ketosis, hypocalcemia, indigestion and abomasal displacement, the severe fatty infiltration in liver was seen and GOT and FFA values were found to be increased in the same cases. In the mastitis and metritis cases, the fatty liver was not observed. The glucose level was decreased and the total lipid value was increased in all cases.
