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Öğe The association between irisin levels, element distribution and oxidative stress markers in adolescent swimmers(WALTER DE GRUYTER GMBH, 2018) Belviranli, Muaz; Okudan, Nilsel; Karakuyu, NuranThe objective of this investigation was to compare irisin concentration and its relation with oxidative stress markers, antioxidant enzymes and element levels in both male adolescent swimmers and sedentary controls. Twelve male swimmers aged between 11 and 18 years, who performed regular swimming training for at least 2 years and 12 age- and gender-matched sedentary controls participated in this study. After anthropometric measurements were performed, fasting venous blood samples were taken at rest. Irisin, malondialdehyde (MDA) as a marker of oxidative stress, superoxide dismutase (SOD) as a marker of antioxidant enzyme and elements (Zn, Cu, Se, Cr, Ni, Al, Fe) were analyzed in these samples. MDA levels were lower but Zn levels and Zn/Cu ratio were higher in the swimmers than in sedentary controls (p < 0.05). There was no statistically significant difference in the irisin levels and SOD activities between the groups (p > 0.05). The results of the current study suggested that exercise training has antioxidant effects and may reduce oxidative damage. Exercise training has also limited effects on irisin levels in the adolescents.Öğe Association between pentraxin-3 and growth differentiation factor-15 in adolescent male swimmers(WILEY-BLACKWELL, 2015) Karakuyu, Nuran; Belviranli, Muaz; Okudan, Nilsel[Abstract not Available]Öğe Circulating levels of leptin, nesfatin-1 and kisspeptin in postmenopausal obese women(TAYLOR & FRANCIS LTD, 2016) Celik, Feyza; Belviranli, Muaz; Okudan, NilselThe roles of leptin, nesfatin-1 and kisspeptin in the regulation of food intake and/or reproduction are well known; however, the interactions between these hormones remain unclear, especially in humans. The aim of this study was to determine the roles of leptin, nesfatin-1 and kisspeptin in pre- and postmenopausal obese and non-obese women. The study included 83 women who were divided into four groups based on menopausal status and body mass index. The leptin level was significantly higher in the obese women than in the non-obese women (p<0.05), but did not differ significantly between pre- and postmenopausal women (p>0.05). The nesfatin-1 and kisspeptin-1 levels did not differ significantly between any of the study groups (p>0.05). The present findings show that nesfatin-1 and kisspeptin levels are not affected by obesity or menopausal status.Öğe Coenzyme Q(10) and its Relation with Oxidant and Antioxidant System Markers in Patients with End-Stage Renal Disease(INFORMA HEALTHCARE, 2011) Gokbel, Hakki; Atalay, Huseyin; Okudan, Nilsel; Solak, Yalcin; Belviranli, Muaz; Turk, SuleymanRationale and objectives: Oxidative stress is increased in chronic kidney disease (CKD) patients and end-stage renal disease (ESRD) patients undergoing dialysis treatment. Coenzyme Q(10) (CoQ(10)) is a ubiquitous and strong antioxidant. Role of CoQ(10) is not fully evaluated in renal patients. We aimed to investigate the relationship of CoQ(10) with oxidant and antioxidant system markers in patients with renal disease. Material and methods: Forty patients with CKD (stages 3--5) who were managed conservatively without dialysis treatment, 40 hemodialysis, and 60 chronic ambulatory peritoneal dialysis (CAPD) patients were included in the study. Biochemical and whole blood analyses were done using hospital auto-analyzers from stored samples. Serum CoQ(10), malondialdehyde (MDA), superoxide dismutase (SOD), and antioxidant activity (AOA) levels were determined. Main findings: There was no difference among the groups in terms of serum CoQ(10) levels. However, other components of antioxidant system, namely, SOD and AOA were significantly higher in CAPD patients when compared to CKD patients. MDA levels were not significantly different among the groups. Principal conclusion(s): The results of this study showed no difference among CKD, CAPD, and hemodialysis patients in terms of serum CoQ(10) levels.Öğe Coenzyme Q10 does not prevent exercise-induced muscle damage and oxidative stress in sedentary men(EDIZIONI MINERVA MEDICA, 2018) Okudan, Nilsel; Belviranli, Muaz; Torlak, SavasBACKGROUND: The objective of this study was to examine the effects of coenzyme Q10 (CoQ10) supplementation on exercise-induced muscle damage and oxidative stress in sedentary young men. In this study, a total of 21 sedentary and healthy young men participated. METHODS: Participants were assigned at random to a CoQ10 or a placebo group employing a double-blind method. Those in the CoQ10 group ingested 200 mg CoQ10 per day for 4 weeks. Those in the placebo group ingested the same dosage of a placebo. After the 4-week period, the same measurements and blood sampling were taken. At this point, eccentric exercise protocols (90 degrees flexion and 180 degrees extension, velocity 60 degrees/s) were instigated for all subjects in isokinetic exercise dynamometry. After exercise, blood samples were taken immediately, 24, and 48 hours later. Blood samples were analyzed for plasma CoQ10 levels, serum creatine kinase (CK) activities, myoglobin (Mb) levels, plasma total superoxide dismutase (SOD) activities and malondialdehyde (MDA) levels. RESULTS: Plasma CoQ10 levels were higher in the CoQ10 supplemented group than in the placebo group (P<0.05). CK activities and levels of Mb increased in both groups 24 and 48 hours after exercise (P<0.05), but no significant difference between the groups was observed (P>0.05). Plasma total SOD activity and MDA levels were not significantly different in both groups 24 and 48 hours after exercise (P>0.05). CONCLUSIONS: CoQ10 supplementation does not prevent exercise induced muscle damage and oxidative stress in sedentary young men.Öğe Curcumin Modulates Muscle Damage but not Oxidative Stress and Antioxidant Defense Following Eccentric Exercise in Rats(VERLAG HANS HUBER, 2014) Boz, Ismail; Belviranli, Muaz; Okudan, NilselAim: The purpose of this study was to investigate the effects of curcumin on eccentric exercise-induced muscle damage and oxidative stress in rats. Methods: Thirty male Wistar rats were divided into four groups: Control (C; no curcumin, no exercise; n=6), Curcumin (Cur; n=8), Exercise (E; n=8) and Exercise Plus Curcumin (ECur; n=8). Curcumin was given for 20 days via oral gavage at doses of 200 mg/kg(-1) of body weight per day, dissolved in corn oil. On the 21st day eccentric exercise was provided via a treadmill run and the rats were sacrificed immediately after. Results: Eccentric exercise resulted in significant (p < 0.05) increases in all injury markers such as creatine kinase (CK) and myoglobin, but curcumin supplementation tended to decrease CK activity (p > 0.05) and significantly decreased myoglobin levels (p < 0.05). In blood and muscle samples, malondialdehyde (MDA) levels were not affected by either curcumin or exercise (p > 0.05). MDA levels in liver tissue decreased in the ECur group, compared to the control (p < 0.05). Superoxide dismutase (SOD) activities and glutathione (GSH) levels were affected by neither curcumin nor exercise (p > 0.05), in blood, muscle and liver tissues. Conclusion: The results of this study suggest that curcumin has a protective effect on eccentric exercise induced muscle damage, and that this effect might be independent of oxidative stress and antioxidant systems.Öğe Cytokeratin 18 and h-FABP levels in intestinal ischemia-reperfusion injury: role of coenzyme Q10(TUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEY, 2013) Belviranli, Muaz; Okudan, Nilsel; Gokbel, Hakki; Kiyici, Aysel; Oz, Mehmet; Kumak, AyseAim: The objective of this study was to investigate whether coenzyme Q10 (CoQ10) supplementation affects M30 and heart-type fatty acid binding protein (h-FABP) levels in intestinal ischemia reperfusion injury-induced rats. Materials and methods: Thirty-two male Wistar rats were randomly divided into 4 groups. 1) Sham: Animals exposed to laparotomy without clamping the superior mesenteric artery (SMA); 2) ischemia-reperfusion (IR): rats exposed to laparotomy with occlusion of the SMA for 45 mm, followed by 120 min of reperfusion period; 3) CoQ10 plus sham: 10 mg kg body weight(-1) CoQ10 was administrated via intraperitoneal injection for 20 days, and thereafter animals were exposed to laparotomy without clamping the SMA; 4) CoQ10 plus IR: 10 mg kg body weight(-1) CoQ10 was administrated via intraperitoneal injection for 20 days and thereafter animals were exposed to laparotomy with occlusion of the SMA for 45 mm, followed by 120 min of reperfusion period. Blood samples were taken by cardiac puncture for the analysis of serum h-FABP and M30 levels. Results: There was no difference among the groups for serum h-FABP and M30 antigen levels. Conclusion: Neither intestinal ischemia-reperfusion injury nor CoQ10 supplementation affect serum h-FABP and M30 levels in rats.Öğe The Effect of Supplementation of Grape Seed Proanthocyanidin Extract on Vascular Dysfunction in Experimental Diabetes(MARY ANN LIEBERT, INC, 2011) Okudan, Nilsel; Bariskaner, Hulagu; Gokbel, Hakki; Sahin, Ayse Saide; Belviranli, Muaz; Baysal, HaticeIncreased oxidative stress and impaired endothelium-dependent relaxation could underlie many of the vascular complications associated with diabetes. We aimed to investigate the effect of supplementation with grape seed proanthocyanidin extract (GSPE), a natural antioxidant, on vascular responses and oxidative stress in streptozotocin-induced diabetic rats. Male Sprague-Dawley rats were divided into three groups: control rats, untreated diabetic rats, and GSPE (100 mg/kg, for 6 weeks)-supplemented diabetic rats. Thoracic aorta rings of the rats were mounted in organ baths, and relaxant responses to acetylcholine (ACh), A23187, and sodium nitroprusside (SNP) were assayed in tissues precontracted with 60mM KCl. Plasma samples used for the measurement of malondialdehyde (MDA) level and superoxide dismutase (SOD) activity. The endothelium-dependent relaxations in response to ACh and A23187 were impaired, but endothelium-independent relaxation in response to SNP did not change in diabetic rats. Supplementation with GSPE significantly improved the relaxant responses to ACh and A23187. The MDA level was significantly elevated and the plasma SOD activity was decreased in diabetic rats, but supplementation with GSPE attenuated the elevated MDA levels and increased plasma SOD activity. Thus supplementation of GSPE may attenuate oxidative stress through the inhibition of lipid peroxidation and may restore endothelial function and reduce the risk of vascular disease in diabetes.Öğe Effects of Acute High Intensity Interval Exercise on Irisin and Myostatin Responses in Elite Kickboxers(LIPPINCOTT WILLIAMS & WILKINS, 2016) Belviranli, Muaz; Kabak, Banu; Okudan, Nilsel[Abstract not Available]Öğe Effects of Coenzyme Q10 Supplementation on Doxorubicin Treatment-induced Cognitive Dysfunction in Rats(WILEY-BLACKWELL, 2016) Okudan, Nilsel; Belviranli, Muaz; Sezer, Tugba[Abstract not Available]Öğe Effects of Coenzyme Q10 Supplementation on Exercise Performance and Markers of Oxidative Stress in Hemodialysis Patients: A Double-Blind Placebo-Controlled Crossover Trial(LIPPINCOTT WILLIAMS & WILKINS, 2016) Gokbel, Hakki; Turk, Suleyman; Okudan, Nilsel; Atalay, Huseyin; Belviranli, Muaz; Gaipov, Abduzhappar; Solak, YalcinCoenzyme Q10 (CoQ10) supplementation has been shown to decrease oxidative stress in a number of clinical settings. However, there are mixed results regarding the role of CoQ10 supplementation on exercise performance. Chronic kidney disease is recognized as an inflammatory state, and hemodialysis patients have low level of exercise performance. We aimed to evaluate the effect of CoQ10 supplementation on oxidative stress markers and exercise performance measures. This was a prospective, double-blind, placebo-controlled, crossover study in which all patients received placebo and oral CoQ10 200 mg/d. Participants underwent 6-minute walking test and cycle ergometer. Blood samples were drawn to determine malondialdehyde, oxidized low-density lipoprotein, superoxide dismutase, and glutathione peroxidase. Walking distance in 6-minute walking test and estimated maximal oxygen consumption (VO2max) were recorded. Twenty-eight patients were randomized, but 23 patients completed the study protocol. Serum CoQ10 level significantly increased with supplementation compared with basal values (P < 0.05). Neither walking distance nor estimated VO2max was different between the placebo and CoQ10 groups (P > 0.05). Serum malondialdehyde levels significantly increased in both groups compared with baseline values just after the exercise (P < 0.05). There was no difference in markers of oxidative stress and antioxidant system between placebo and CoQ10 supplementation with exercise (P > 0.05). The results of this study showed no significant effect of CoQ10 supplementation on exercise performance measures and oxidative system markers compared with placebo in maintenance hemodialysis patients.Öğe The Effects of Coenzyme Q10 Supplementation on Performance During Repeated Bouts of Supramaximal Exercise in Sedentary Men(Lippincott Williams & Wilkins, 2010) Gökbel, Hakkı; Gül, İbrahim; Belviranli, Muaz; Okudan, NilselGokbel, H, Gul, I, Belviranli, M, and Okudan, N. The effects of coenzyme Q10 supplementation on performance during repeated bouts of supramaximal exercise in sedentary men. J Strength Cond Res 24(1): 97-102, 2010-The objective of this study was to determine the effects of oral coenzyme Q10 (CoQ10) supplementation on performance during repeated bouts of supramaximal exercise. This randomized, double-blind, crossover study was composed of two 8-week periods of supplementation with either 100 mg.d(-1) CoQ10 or placebo. Fifteen healthy and sedentary men participated in the study. Five Wingate tests (WTs) with 75 g.kg(-1) body weight load with 2-minute intervals between tests were performed 3 times at baseline, after CoQ10, or placebo supplementation during the study period. Peak power (PP), mean power (MP), and fatigue index were calculated. During the 5 WTs, PP and MP tended to decrease and fatigue index tended to increase in all groups (p < 0.05). Peak power decreased with CoQ10 and placebo supplementation during the WT1, WT2, and WT2 (p, 0.05). Mean power increased only with CoQ10 supplementation during the WT5. Fatigue indexes decreased with CoQ10 supplementation, but these decreases did not differ from that seen with placebo supplementation. According to these results, CoQ10 may show performance-enhancing effects during the repeated bouts of supramaximal exercises and CoQ10 might be used as ergogenic aid.Öğe Effects Of Exercise Training And Coenzyme Q10 On Acute Exercise-induced Oxidative Stress In Muscles(LIPPINCOTT WILLIAMS & WILKINS, 2013) Okudan, Nilsel; Balci, Serdar; Belviranli, Muaz; Revan, Serkan; Gokbel, Hakki; Pepe, Hamdi[Abstract not Available]Öğe Effects of Exercise Training and Coenzyme Q10 Supplementation on Oxidative Stress and Antioxidant Defense Markers in Heart Tissue of Aged Rats(WILEY-BLACKWELL, 2015) Okudan, Nilsel; Belviranli, Muaz; Ozdemir, Ayse; Oz, Mehmet[Abstract not Available]Öğe Effects Of Exercise Training And Coenzyme Q10 Supplementation On Pentraxin-3 And Paraoxonase Activities In Aged Rats(LIPPINCOTT WILLIAMS & WILKINS, 2013) Belviranli, Muaz; Okudan, Nilsel; Kumak, Ayse; Nurullahuglu-Atalik, Kismet Esra; Oz, Mehmet[Abstract not Available]Öğe Effects of exercise training on hepatic oxidative stress and antioxidant status in aged rats(TAYLOR & FRANCIS LTD, 2016) Okudan, Nilsel; Belviranli, MuazThis study investigated the effects of exercise training on oxidative stress, and antioxidant defense markers in the liver tissues of young and aged rats. Two age groups of 4-(young) and 20-months-(aged) old male Wistar rats were performed exercise training program consisted of swimming exercise for 8 weeks. The biomarkers of pro/antioxidant status malondialdehyde (MDA), protein carbonyl (PC), 8-hydroxy-2-deoxyguanosine (8-OHdG), total glutathione (GSH) and superoxide dismutase (SOD) were assessed by commercially available kits. PC levels were higher in the untrained aged rats compared to the young groups and exercise training decreased PC levels (p<0.05). 8-OHdG levels were higher in the aged groups (p<0.05). MDA and GSH levels and SOD activity did not differ significantly between the groups (p>0.05). The present findings indicate that exercise training prevents aging-induced hepatic oxidative damage especially in the proteins.Öğe The effects of Ginkgo biloba extract on cognitive functions in aged female rats: The role of oxidative stress and brain-derived neurotrophic factor(ELSEVIER SCIENCE BV, 2015) Belviranli, Muaz; Okudan, NilselThe aim of this study was to investigate the effects of Ginkgo biloba extract (GBE) on cognitive functions as well as oxidative stress and brain-derived neurotrophic factor (BDNF) levels in aged female rats. Rats were divided into 4 groups according to age (young vs. aged) and treatment (GBE vs. vehicle). GBE or vehicle was given for 30 d, and a series of behavioral tests were performed. Following behavioral testing, blood samples and brain tissues were obtained for analysis of BDNF, malondialdehyde (MDA), 8-hydroxy-2'-deoxyguanosine (8-OHdG), and glutathione levels, and superoxide dismutase activity. Locomotor activity and anxiety levels were lower in the aged rats. Based on Morris water maze probe trial findings, GBE supplementation increased the number of platform crossings in the aged rats. MDA and 8-OHdG levels were lower in the brain tissue, and BDNF levels were higher in plasma in the rates treated with GBE. Based on these findings, we concluded that GBE supplementation improved cognitive functions by decreasing oxidative damage and increasing the BDNF level in aged female rats. (C) 2014 Elsevier B.V. All rights reserved.Öğe Effects of grape seed extract on oxidative stress and antioxidant defense markers in streptozotocin-induced diabetic rats(TUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEY, 2015) Belviranli, Muaz; Gokbel, Hakki; Okudan, Nilsel; Buyukbas, SadikBackground/aim: To evaluate the effects of grape seed extract (GSE) supplementation on oxidative stress and antioxidant markers in streptozotocin (STZ)-induced diabetic rats. Materials and methods: Thirty-six male rats were divided into the following four groups: control, GSE-supplemented control, diabetic, and GSE-supplemented diabetic. Beginning on day 7 after STZ injection, the rats were administered GSE (100 mg kg(-1) day(-1)) in drinking water for 6 weeks. At the end of week 6, rats were sacrificed by cardiac puncture. Plasma nitric oxide (NO) levels and xanthine oxidase (XO), adenosine deaminase (ADA), and glutathione peroxidase (GPx) activities were analyzed. Results: Both XO and ADA activities increased and NO levels decreased in diabetic rats (P < 0.05). GSE supplementation normalized all of these changes. Antioxidant enzyme activities decreased in diabetic rats compared to the controls (P < 0.05). GSE supplementation increased antioxidant enzyme activities in both diabetic and healthy rats (P < 0.05). Conclusion: These findings suggest that 6 weeks of oral GSE supplementation may prevent oxidative stress and improve antioxidant status in diabetic rats.Öğe Effects of grape seed extract supplementation on exercise-induced oxidative stress in rats(CAMBRIDGE UNIV PRESS, 2012) Belviranli, Muaz; Gokbel, Hakki; Okudan, Nilsel; Basarali, KemalThe aim of the present study was to investigate the effects of grape seed extract (GSE) supplementation on exercise performance and oxidative stress in acutely and chronically exercised rats. A total of sixty-four male rats were used in the study. Rats were divided into six groups: control, chronic exercise control, acute exercise control (AEC), GSE-supplemented control, GSE-supplemented chronic exercise and GSE-supplemented acute exercise groups. Chronic exercise consisted of treadmill running at 25 m/min, 45 min/d, 5 d a week for 6 weeks. Rats in the acute exercise groups were run on the treadmill at 30 m/min until exhaustion. GSE were given at 100 mg/kg of body weight with drinking water for 6 weeks. Plasma was separated from blood samples for the analysis of oxidative stress markers. There was no significant difference in time of exhaustion between the acute exercise groups. Plasma malondialdehyde (MDA) levels were higher in the acute exercise groups and lower in the chronic exercise groups. GSE supplementation decreased MDA levels. Xanthine oxidase and adenosine deaminase activities were higher in the AEC group compared to all the other groups. NO levels were increased with both chronic exercise and GSE supplementation. Superoxide dismutase and glutathione peroxidase activities were lower in the acute exercised groups and higher in the chronic exercised groups. GSE supplementation caused an increase in antioxidant enzyme activities. In conclusion, GSE supplementation prevents exercise-induced oxidative stress by preventing lipid peroxidation and increasing antioxidant enzyme activities.Öğe Effects of Grape Seed Polyphenols on Oxidative Damage in Liver Tissue of Acutely and Chronically Exercised Rats(WILEY, 2013) Belviranli, Muaz; Gokbel, Hakki; Okudan, Nilsel; Buyukbas, SadikThe objective of the present study was to investigate the effects of grape seed extract (GSE) supplementation on oxidative stress and antioxidant defense markers in liver tissue of acutely and chronically exercised rats. Rats were randomly assigned to six groups: Control (C), Control Chronic Exercise (CE), Control Acute Exercise (AE), GSE-supplemented Control (GC), GSE-supplemented Chronic Exercise(GCE) and GSE-supplemented Acute Exercise (GAE). Rats in the chronic exercise groups were subjected to a six-week treadmill running and in the acute exercise groups performed an exhaustive running. Rats in the GSE supplemented groups received GSE (100 mg.kg1.day1) in drinking water for 6 weeks. Liver tissues of the rats were taken for the analysis of malondialdehyde (MDA), nitric oxide (NO) levels and total antioxidant activity (AOA) and xanthine oxidase (XO) activities. MDA levels decreased with GSE supplementation in control groups but increased in acute and chronic exercise groups compared to their non-supplemented control. NO levels increased with GSE supplementation. XO activities were higher in AE group compared to the CE group. AOA decreased with GSE supplementation. In conclusion, while acute exercise triggers oxidative stress, chronic exercise has protective role against oxidative stress. GSE has a limited antioxidant effect on exercise-induced oxidative stress in liver tissue. Copyright (c) 2012 John Wiley & Sons, Ltd.
