Coenzyme Q(10) and its Relation with Oxidant and Antioxidant System Markers in Patients with End-Stage Renal Disease
Küçük Resim Yok
Tarih
2011
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
INFORMA HEALTHCARE
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Rationale and objectives: Oxidative stress is increased in chronic kidney disease (CKD) patients and end-stage renal disease (ESRD) patients undergoing dialysis treatment. Coenzyme Q(10) (CoQ(10)) is a ubiquitous and strong antioxidant. Role of CoQ(10) is not fully evaluated in renal patients. We aimed to investigate the relationship of CoQ(10) with oxidant and antioxidant system markers in patients with renal disease. Material and methods: Forty patients with CKD (stages 3--5) who were managed conservatively without dialysis treatment, 40 hemodialysis, and 60 chronic ambulatory peritoneal dialysis (CAPD) patients were included in the study. Biochemical and whole blood analyses were done using hospital auto-analyzers from stored samples. Serum CoQ(10), malondialdehyde (MDA), superoxide dismutase (SOD), and antioxidant activity (AOA) levels were determined. Main findings: There was no difference among the groups in terms of serum CoQ(10) levels. However, other components of antioxidant system, namely, SOD and AOA were significantly higher in CAPD patients when compared to CKD patients. MDA levels were not significantly different among the groups. Principal conclusion(s): The results of this study showed no difference among CKD, CAPD, and hemodialysis patients in terms of serum CoQ(10) levels.
Açıklama
Anahtar Kelimeler
Antioxidant system, chronic kidney disease, coenzyme Q(10), hemodialysis, malondialdehyde, oxidative stress, peritoneal dialysis
Kaynak
RENAL FAILURE
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
33
Sayı
7
