Coenzyme Q(10) and its Relation with Oxidant and Antioxidant System Markers in Patients with End-Stage Renal Disease

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dc.contributor.authorGokbel, Hakki
dc.contributor.authorAtalay, Huseyin
dc.contributor.authorOkudan, Nilsel
dc.contributor.authorSolak, Yalcin
dc.contributor.authorBelviranli, Muaz
dc.contributor.authorTurk, Suleyman
dc.date.accessioned2020-03-26T18:13:57Z
dc.date.available2020-03-26T18:13:57Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractRationale and objectives: Oxidative stress is increased in chronic kidney disease (CKD) patients and end-stage renal disease (ESRD) patients undergoing dialysis treatment. Coenzyme Q(10) (CoQ(10)) is a ubiquitous and strong antioxidant. Role of CoQ(10) is not fully evaluated in renal patients. We aimed to investigate the relationship of CoQ(10) with oxidant and antioxidant system markers in patients with renal disease. Material and methods: Forty patients with CKD (stages 3--5) who were managed conservatively without dialysis treatment, 40 hemodialysis, and 60 chronic ambulatory peritoneal dialysis (CAPD) patients were included in the study. Biochemical and whole blood analyses were done using hospital auto-analyzers from stored samples. Serum CoQ(10), malondialdehyde (MDA), superoxide dismutase (SOD), and antioxidant activity (AOA) levels were determined. Main findings: There was no difference among the groups in terms of serum CoQ(10) levels. However, other components of antioxidant system, namely, SOD and AOA were significantly higher in CAPD patients when compared to CKD patients. MDA levels were not significantly different among the groups. Principal conclusion(s): The results of this study showed no difference among CKD, CAPD, and hemodialysis patients in terms of serum CoQ(10) levels.en_US
dc.identifier.doi10.3109/0886022X.2011.589941en_US
dc.identifier.endpage681en_US
dc.identifier.issn0886-022Xen_US
dc.identifier.issue7en_US
dc.identifier.pmid21787158en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage677en_US
dc.identifier.urihttps://dx.doi.org/10.3109/0886022X.2011.589941
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26238
dc.identifier.volume33en_US
dc.identifier.wosWOS:000293096800006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherINFORMA HEALTHCAREen_US
dc.relation.ispartofRENAL FAILUREen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAntioxidant systemen_US
dc.subjectchronic kidney diseaseen_US
dc.subjectcoenzyme Q(10)en_US
dc.subjecthemodialysisen_US
dc.subjectmalondialdehydeen_US
dc.subjectoxidative stressen_US
dc.subjectperitoneal dialysisen_US
dc.titleCoenzyme Q(10) and its Relation with Oxidant and Antioxidant System Markers in Patients with End-Stage Renal Diseaseen_US
dc.typeArticleen_US

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