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    The Effects of Free Radicals on Antioxidant Defence Systems and Organism in Hemodialysis Patients
    (CHEM SOC PAKISTAN, 2011) Yontem, Mustafa; Bilge, Murat; Kaleli, Suleyman; Kurban, Sevil; Celik, Gulperi
    Chronic Renal Failure (CRF) is accompanied by a variety of complications which may develop due to an increase in oxidant stress and/or a decrease in antioxidant activities. Hemodialysis (HD) is still the most prevalent method used for the end stage renal failure throughout the world. In this study, it was aimed to research thoroughly whether an increase in lipid peroxidation occurs in hemodialysis patients with advanced CRF and to evaluate antioxidant enzyme activities. Plasma MDA which is the indicator of lipid peroxidation and plasma SOD, CAT, GSH-Px levels as well as total antioxidant status (TAS) values which are the indicators of antioxidant defense systems have been determined in CRF patients who have undergone hemodialysis treatment and in the control group. Compared to those found in the control group, MDA and SOD levels in CRF patient group have statistically increased (p<0,001), while GSH-Px and CAT values have been found to decrease (p<0,001). TAS values have been determined to increase in the control group before the hemodialysis and to decrease after the hemodialysis, which is statistically insignificant. With regard to the correlation calculation we've made, a statistically positive correlation have been found between urea and creatinine both pre- and after hemodialysis, while no statistically significance have been recorded among other parameters.
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    The Relationship Between Glutathione Peroxidase and Bioimpedance Parameters in Nondiabetic Hemodialysis Patients
    (WILEY-BLACKWELL, 2012) Çelik, Gülperi; Yöntem, Mustafa; Cilo, Mustafa; Bilge, Murat; Mehmetoğlu, İdris; Ünaldı, Mustafa
    There is growing evidence from experimental and clinical studies that oxidative stress is involved in the pathogenesis of malnutrition. This cross-sectional study aimed to investigate the relationship between glutathione peroxidase (GPx) levels as a marker of antioxidant status and the nutritional status assessed by bioimpedance analysis (BIA). Ninety-seven nondiabetic stable outpatient uremic adults undergoing chronic hemodialysis (HD) were recruited for this study. Impedance measurements were performed using a multifrequency bioelectrical impedance analyzer after dialysis. GPx levels correlated with intracellular water (ICW) (r?=?0.341, P?=?0.011), ICW/total body weight (r?=?0.320, P?=?0.017), lean body mass (r?=?0.300, P?=?0.026) and total body cell mass (r?=?0.339, P?=?0.011). When patients were divided into two groups according to mean GPx levels (83.9 U/gr hemoglobin), the patients with higher GPx (GPx?>?83.9?U/gr hemoglobin) had higher albumin (P?=?0.038), lean body mass (P?=?0.026), ICW (P?=?0.011), and total body cell mass (P?=?0.011) compared with those with lower GPx (GPx?=?83.9 U/gr hemoglobin). Furthermore, in the patients with higher GPx, body fat; extracellular water/total body water; illness marker and body fat mass index were lower than other group. In conclusion, our results reveal correlation indicating a relationship between antioxidant status (as measured by GPx) and nutritional status as assessed by BIA in nondiabetic HD patients.