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Öğe Does preoperative administration of allopurinol protect the lungs from ischemia-reperfusion injury occuring during cardiopulmonary bypass?(COMENIUS UNIV, 2013) Gormus, Z., I; Celik, J. B.; Ergene, N.; Gormus, N.; Baltaci, A. K.Background: It is investigated whether preoperative allopurinol administration protects lung injury induced by cardiopulmonary bypass (CPB). Methods: Sixty patients with coronary artery disease who need elective coronary artery bypass grafting operations by using CPB were taken into this study. They were divided into two groups; control and allopurinol. Allopurinol (300 mg/day) was administered to the latter group during the preoperative period of 5 days. Standard CPB procedures were used in all cases. Blood was sampled for TNF-alpha, IL-6, IL-8, IL-10 before anesthesia (T0), after anesthesia and before skin incision (T1), before CPB (T2), after aortic declamping (T3), at the end of CPB (T4), 6 hours after operation (T5), 12 hours after operation (T6), and 24 hours after operation (T7). Pulmonary function test (PFT) was performed before and following the 6th day of operation. Results: TNF-alpha, IL-6, IL-8 increased in both groups at T3, T4, T5 and T6 compared to control (p<0.05). TNF-alpha, IL-6, and IL-8 levels were lower in group A at T3, T4, T5 and T6 (p<0.05). Creatinin phosphokinase (CK) levels were lower in group A at T6 (p<0.05). CK-MB levels were lower in group A than in group C (p<0.05). Pulmonary function test (PFT) did not yield any differences between the groups. Conclusions: Preoperative allopurinol administration decreases the inflammation and myocardial injury according to biochemical markers of ischemia reperfusion injury. However, this biochemical success does not rebound to PFT (Tab. 5, Ref. 15). Full Text in PDF www.elis.sk.Öğe DOPAMINERGIC CHALLENGE WITH BROMOCRIPTINE IN PATIENTS WITH SEVERE TRAUMATIC BRAIN INJURY(ELSEVIER, 2015) Celik, J. B.; Duman, A.; Arun, O.; Onal, I. O.[Abstract not Available]Öğe The Effects of Intrathecal Morphine on Patient-controlled Analgesia, Morphine Consumption, Postoperative Pain and Satisfaction Scores in Patients Undergoing Gynaecological Oncological Surgery(SAGE PUBLICATIONS LTD, 2012) Kara, I.; Apiligullari, S.; Oc, B.; Celik, J. B.; Duman, A.; Celik, C.; Dogan, N. U.OBJECTIVE: Gynaecological oncological surgery (GOS) includes a wide variety of surgical procedures and postoperative pain is a major concern. This study compared the impact of intrathecal morphine (ITM) plus patient-controlled analgesia (PCA) with PCA alone on morphine consumption, pain relief and patient satisfaction after GOS. METHODS: Sixty women undergoing GOS under general anaesthesia were randomized to receive either 0.3 mg ITM or placebo. On arrival at the postanaesthesia care unit each patient received a morphine PCA pump. The three primary outcome measures were pain, patient satisfaction scores evaluated using a 100-mm visual analogue scale and cumulative PCA morphine consumption. RESULTS: No significant differences were observed in the demographic data. Cumulative PCA morphine consumption was significantly lower in the ITM group compared with the control group. Fatigue scores were lower in the ITM group compared with the control group but did not reach statistical significance. Pain, sedation and patient satisfaction scores, and the rate of side-effects were similar for the two groups. CONCLUSIONS: Administering ITM in GOS could improve postoperative analgesia and reduce morphine consumption without serious side-effects.Öğe Intraarticular Local Anesthetics: Primum Non Nocere(Springer, 2012) Erkocak, O. F.; Aydin, B. K.; Celik, J. B.[Abstract not Available]Öğe A novel therapeutic approach in tetanus: Botulinum toxin(ELSEVIER SCI LTD, 2014) Demir, N. Aktug; Ozturk, S.; Sumer, S.; Ural, O.; Celik, J. B.; Ozcimen, S.[Abstract not Available]Öğe Protective role of zinc pretreatment in hepatotoxicity induced by halothane(CAMBRIDGE UNIV PRESS, 2008) Unsal, C.; Celik, J. B.; Toy, H.; Esen, H.; Otelcioglu, S.Background and objective: This study was designed to determine the protective effects of zinc on halothane-induced hepatotoxicity. Methods: Forty-five male Sprague-Dawley rats were divided into three groups. The hatothane group received normal drinking water and diet; the zinc-halothane group received 227 mgL(-1) zinc sulphate in the drinking water and diet for 2 weeks; and the control group received normal diet and water. At the end of 2 weeks, rats were housed in an anaesthesia box and 1 MAC (minimum alveolar concentration) halothane was administered at 6 L min(-1) in room air for 2 h. This was repeated 48 h later. After the rats were scrificed, we measured alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, glutamyl transpeptidase, glutathione-S-transferase, serum electrolytes and bilirubin in samples. The degree of liver toxicity was assessed by light microscopic examination. Results: We demonstrated a reduction of alanine aminotransferase, aspartate amino transferase, glutathione-S-transferase levels and a reduction in liver damage in the zinc-halothane group. Conclusion: The study concludes that zinc has the potential to alleviate the toxic effects of halothane in rat liver.Öğe THE REVERSAL EFFECT OF ONDANSETRON ON LOCAL ANESTHESIA IN THE THERMAL PAIN MODEL OF RATS(ELSEVIER, 2015) Apiliogullari, S.; Ileri, Z.; Onal, O.; Taylan, S. B.; Saltali, A. O.; Bariskaner, H.; Celik, J. B.[Abstract not Available]Öğe The role of immunonutrition in gynecologic oncologic surgery(7847050 CANADA INC, 2009) Celik, J. B.; Gezginc, K.; Ozcelik, K.; Celik, C.Background: This study assesses the effect of immunonutrition on biochemical and hematological parameters, incidence of infection, postoperative complications, mortality rate and length of hospital stay. Material and Methods: A total of 50 patients operated on for gynecological malignancies were randomly assigned to two groups, each receiving two days preoperative and seven days postoperative enteral nutrition after intestinal movements started. The patients in group 1 were given 1000 kcal/d immun-enhancing enteral nutrition (IEN). The patients in group 2 received 1000 kcal/d standard enteral nutrition. The nutritional (albumin, prealbumin). immunologic (CRP, white blood cell (WBC) count, lymphocyte population) parameters, length of hospital stay (LOS) and clinical outcomes were examined. Results: The two groups did not differ in terms of demogaphic data, nutritional status, surgical status. mortality rate (p > 0.05). WBC count, lymphocyte population. CRP levels were significantly higher in group 1 compared with group 2 in the postoperative period (p < 0.05). Pulmonary and urinary tract infection rates were similar in both groups (p > 0.05) but Wound infection, and LOS rate were significantly lower in group 1 than group 2 (p < 0.05). Conclusion: Perioperative immunonutrition proved to be safe and useful in increasing the immunologic response. It may decrease postoperative complications and LOS in patients undergoing surgery for gynecological malignancy.
