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Öğe 677C > T and 1298A > C Polymorphisms of Methylenetetrahydropholate Reductase Gene and Biochemical Parameters in Turkish Population with Spina Bifida Occulta(Turkish Neurosurgical Soc, 2010) Eser, Betül; Coşar, Murat; Eser, Olcay; Erdoğan, Müjgan O.; Aslan, Adem; Yıldız, Handan; Boyacı, Gazi; Büyükbaş, Sadık; Solak, MustafaAIM: This study aimed to investigate the 677C>T and 1298A>C MTHFR gene polymorphisms and their metabolic effects on the levels of folate, vitamin B12 and homocysteine in the serum of Turkish spina bifida occulta (SBO) patients and healthy individuals in disease. MATERIAL and METHODS: A case-control study was performed to detect 677C>T and 1298A>C MTHFR gene polymorphisms in 39 SBO patients and 34 healthy individuals. The folate, vitamin B12 and homocysteine concentrations in the serum of SBO and healthy individuals were evaluated and compared with MTHFR gene polymorphisms. RESULTS: 677 CC/CT/TT MTHFR genotype frequency differences between the SBO patients and controls were not significant (x(2)=3.325, P=0.068; x(2)=1.479, P=0.224; x(2)=0.275, P=0.600; respectively). 1298A>C MTHFR genotype frequency differences between the SBO patients and controls were significant (x(2)=8.477, P=0.004). The frequencies of the A and C alleles of the 1298A>C polymorphism did not differ in a statistically significant manner between the groups (x(2)=0.576, P=0.448). The biochemical parameters were not significantly different between SBO patients and healthy individuals (P>0.05). CONCLUSION: The 677C>T and 1298A>C polymorphisms of the MTHFR gene cannot be regarded as major risk factors for SBO in the Turkish patients 677TT homozygosity may affect the metabolism of homocysteine.Öğe Apoptosis and Cerebral Ischemic Reperfusion Injury Developed After Haemorrhagic Shock: Experimental Study(2006) Kalkan, Erdal; Eser, Olcay; Avunduk, Mustafa Cihat; Coşar, Murat; Fidan, Hüseyin; Kalkan, SerpilBACKGROUND: Apoptosis is a process of programmed cell death that plays a role in some normal and pathological conditions. In this study, we investigated the apoptosis during cerebral ischemic reperfusion injury in response to haemorrhagic shock in a rat model. METHODS: Thirty-six adult Sprague-Dawley rats were divided into six groups: control, haemorrhagic shock (HS), ischemic reperfusion (IR), 1st hour IR, 3rd hour IR, 6th hour IR and 24th hour IR. Rats were sacrificed by taking blood from intracardiac area after finishing the experiment. The tissues were fixed using neutral buffered 10% formaldehyde solution for histopathological examination. Tissues were stained immunohistochemically with APO 2.7 and positive expression apoptotic cells were counted using a Clemex Vision Lite 3.5 vision analysis system. RESULTS: There were 2-3 apoptotic cells in the control group (group 1) and this number increased to 8-11 in the haemorrhagic shock group (group 2) (p<0.05). Secondary or more serious injury occurs during ischemic reperfusion injury. The number of apoptotic cells increased to 11-14 at the 1st hour (group 3) and it was significant as compared to group 2 (p<0.05). The number of apoptotic cells significantly increased to 15-17 by the 3rd hour (group 4) as compared to group 3 (p<0.05). While there was no additional increase by the end of the 6th hour (group 5) as compared to group 4, the number of apoptotic cells significantly increased to 18-24 by the end of 24th hour (group 6) as compared to group 5 (p<0.05). CONCLUSION: The majority of injuries to the brain following haemorrhagic shock occur during ischemic reperfusion. We observed that apoptosis increases step by step on the 1st, 3rd and 24th hours after ischemic reperfusion injury.Öğe Kyphoplasty method for the treatment of traumatic osteoporotic vertebral compression fractures: Case report(2010) Eser, Olcay; Aslan, Adem; Coşar, Murat; Kalkan, Erdal; Albayrak, RamazanThe aim of the kyphoplasty method for the treatment of traumatic osteoporotic vertebral compression fractures in geriatric patients is to improve the patient's quality of life. In this report we present two elderly patients who were suffering of traumatic osteoporotic vertebral compression fractures and underwent successful kyphoplasties. Percutaneous kyphoplasty method for the surgical treatment of these fractures decreases the hospitalization, morbidity and mortality in these patients.Öğe Travmaya Bağlı Osteoporotik Vertebra Çökme Kırıklarının Tedavisinde Kifoplasti Uygulaması: Olgu Sunumu(2010) Eser, Olcay; Aslan, Adem; Coşar, Murat; Kalkan, Erdal; Albayrak, RamazanYaşlılarda travmaya bağlı oluşan osteoporotik vertebra çökme kırıklarının tedavisinde uygulanan kifoplasti yöntemiyle hastaların yaşam kalitesinin arttırılması amaçlanmıştır. Bu yazıda travmatik osteoporotik vertebra çökme kırığı nedeniyle başvuran ve tedavilerinde başarıyla kifoplasti ameliyatı uygulanan iki yaşlı hastanın özellikleri ve sonuçları sunuldu. Osteoporotik vertebra çökme kırıklarının cerrahi tedavisinde perkütan olarak uygulanan kifoplasti, hastaların hastanede kalış sürelerini kısaltmakta, morbidite ve mortalitesini önemli derece azaltmaktadır.Öğe Travmaya Bağlı Osteoporotik Vertebra Çökme KırıklarınınTedavisinde Kifoplasti Uygulaması: Olgu Sunumu(TURKISH ASSOC TRAUMA EMERGENCY SURGERY, 2010) Eser, Olcay; Aslan, Adem; Coşar, Murat; Kalkan, Erdal; Albayrak, RamazanThe aim of the kyphoplasty method for the treatment of traumatic osteoporotic vertebral compression fractures in geriatric patients is to improve the patient's quality of life. In this report we present two elderly patients who were suffering of traumatic osteoporotic vertebral compression fractures and underwent successful kyphoplasties. Percutaneous kyphoplasty method for the surgical treatment of these fractures decreases the hospitalization, morbidity and mortality in these patients.
