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Öğe Asymmetric dimethylarginine and arginine levels in patients with rheumatoid arthritis(WALTER DE GRUYTER GMBH, 2013) Vatansev, Husamettin; Ozturk, Bahadir; Yilmaz, Sema; Sivrikaya, Abdullah; Dagli, Mehmet; Kiyici, Aysel; Unlu, AliObjective: Rheumatoid arthritis (RA) is a chronic inflammatory disease and it is associated with premature atherosclerosis development. RA patients have multiple factors to develop premature atherosclerosis. Enhanced asymmetric dimethylarginine (ADMA) is considered as a risk factor for the development of atherosclerosis by inducing endothelial dysfunction. The aim of this study was to investigate the role of asymmetric dimethylarginine, arginine and citrulline levels in patients with RA and their relation to the disease activity parameters for possible role on the disease activity. Methods: 92 patients with RA and 34 healthy controls were included the study. Patients and control blood samples collected for ADMA, arginine and citrulline levels. ADMA, arginine and citrulline levels were measured by pre-column derivatization fluorescence HPLC method. CRP and ESR levels examined on the same day were taken from the patient records. Results: While ADMA levels significantly increased, arginine levels decreased in the patient group. There was no difference in citrulline levels between both groups. Only citrulline and arginine showed a weak positive correlation. ADMA, arginine, and citrulline levels showed no correlation with either biochemical parameters such as CRP or ESR, or disease activity or disease severity. Conclusion: Our study has shown that an increase in ADMA levels with the decrease in arginine levels suggests an increase in arginine turnover to ADMA. Increased ADMA levels can be used for an increased risk for premature development of atherosclerosis in patients with RA. Since high ADMA levels prevent the NO-dependent vasodilatation, a possible role of ADMA in development of premature atherosclerosis may be independent from inflammation.Öğe Asymmetric dimethylarginine levels in Behcet's disease(WALTER DE GRUYTER GMBH, 2014) Ozturk, Bahadir; Vatansev, Husamettin; Taner, Alpaslan; Yilmaz, Sema; Dagli, Mehmet; Unlu, AliObjective: Behcet's disease (BD) is a chronic, inflammatory, multisystem vasculitis and the etiology is not yet fully understood. Nitric Oxide (NO) is an important molecule for the vascular system which synthesised by the Nitric Oxide Synthase (NOS) enzyme. Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of NOS. Therefore, we aimed to investigate levels of the ADMA and its relation with exacerbations in BD patients. Methods: The subjects enrolled in this study were recruited from 34 patients with BD and 34 healthy controls. Serum levels of ADMA, arginine and citrulline were measured by HPLC with fluorescence detection. The ESR and CRP levels analyzed by routinely used methods. Results: In contrast to information in the literature, ADMA levels were found to be decreased in BD patients when compared to control. Inversely, Arginine and Citrulline levels were significantly increased in BD patients. Increased Arginine/ADMA ratios were found in the patient group. There was an inverse relation between ADMA and CRP levels. Arginine values were also correlated CRP and Citrulline levels. Conclusion: One of the reasons of high number of BD attacks in young age may be low levels of ADMA. Our study suggests that the reduced levels of ADMA in patients group may impose a possible preventive role to ADMA through decrease of NO-mediated inflammation and exacerbations of BD with aging.Öğe An atypical isolated CNS blast crisis in chronic myeloid leukaemia(MA HEALTHCARE LTD, 2018) Sivri, Mesut; Paksoy, Yahya; Dagli, Mehmet; Kelesoglu, Kazim Serhan; Koplay, Mustafa[Abstract not Available]Öğe Autoimmune hepatitis-primary biliary cirrhosis overlap syndrome concomitant with immune hemolytic anemia and immune thrombocytopenic purpura (Evans syndrome)(ELSEVIER MASSON, CORPORATION OFFICE, 2013) Korkmaz, Huseyin; Bugdaci, Mehmet Sait; Temel, Tuncer; Dagli, Mehmet; Karabagli, PinarAutoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC) associated with Evans syndrome; combination of autoimmune hemolytic anemia (AIHA) and immune thrombocytopenic purpura (ITP) has rarely been reported. We report the case of a 53-year-old patient who presented with weakness, myalgia, arthralgia, shortness of breath and purpura. Initial laboratory investigations revealed liver dysfunction, anemia and thrombocytopenia. Anti-nuclear (ANA) and antimitochondrial M2 (AMA M2) antibodies were positive. Diagnose of PBC-AIH overlap was made by clinical, serological and histological investigations. AIHA and ITP was identified with clinical-laboratory findings and bone marrow puncture. She was treated with IVIG followed by prednisolone and ursodeoxycholic acid. Hemoglobin-thrombocytes increased rapidly and transaminases improved at day 8. We have reported the first case in the literature with AIH-PBC overlap syndrome concurrent by ITP and AIHA which suggest the presence of shared genetic susceptibility factors in multiple autoimmune conditions including AIH, PBC, ITP and AIHA. (C) 2012 Elsevier Masson SAS. All rights reserved.Öğe Clinical significance of Beta-2 glycoprotein I antibodies in BcrAbl (-) myeloproliferative neoplasms(ALLIED ACAD, 2017) Kocak, Mehmet Zahid; Dagli, Mehmet; Unlu, AliBackground: Beta-2 glycoprotein I antibodies (B2-GPI Ab) are significant markers of thrombosis in otoimmune diseases. No literature has been found in Bcr Abl (-) MPNs to exclude the risk of hereditary thrombophilia and to investigate the association of B2-GPI Ab levels with thrombosis. This study aimed to investigate the relation between levels of B2-GPI Ab and thrombosis in BcrAbl (-) MPN without the risk of hereditary thrombophilia. Methods: Plasma samples from healthy volunteers and BcrAbl (-) MPN's patients with and without thrombosis were collected after receiving consent. B2-GPI Ab in plasma was quantified by enzyme-linked immunosorbent assay and the data were analyzed to determine whether plasma.2-GPI Ab correlates significantly with thrombosis. Result: There was a statistically significant difference between the B2-GPI Ab levels of the patients and the control group (p=0.006). However, no statistically significant difference in levels of B2-GPI between patients with and without thrombosis history was determined (p=0.144). Conclusion: This study supports that no relationship between levels of B2-GPI Ab and thrombosis complications in BcrAbl (-) MPN.Öğe THE EFFECTS OF ANEMIA AND RED CELL TRANSFUSION ON THE RISK OF MORTALITY AMONG GERIATRIC AND NON-GERIATRIC PATIENTS WITH HOSPITAL-ACQUIRED INFECTIONS IN AN INTENSIVE CARE UNIT(GUNES KITABEVI LTD STI, 2015) Kutlucan, Leyla; Kutlucan, Ali; Basturk, Abdulkadir; Kandis, Hayati; Titiz, Hafize; Senocak, Elif; Dagli, MehmetIntroduction: This study aimed to investigate the effects of anemia and red blood cell transfusion on the risk of mortality in geriatric and non-geriatric Intensive Care Unit patients with Hospital-Acquired Infection. Materials and Method: This study included 546 patients aged >= 18 years; from these, 112 patients had Hospital-Acquired Infection. Results: Among the patients aged >= 65 years with Hospital-Acquired Infection who were treated in the medical Intensive Care Unit, the risk of mortality was significantly increased in patients with anemia or history of diabetes; in patients who were intubated or in patients with neurological disorders or respiratory failure. Although the abovementioned factors increased the risk of mortality in the elderly, the same relationship was not observed in patients aged<65 years. In addition, blood transfusion did not increase the risk of mortality in patients belonging to both the age groups. Conclusion: We conclude that in geriatric Intensive Care Unit patients with Hospital-Acquired Infection, anemia increases the risk of mortality but red cell transfusion does not affect the risk of mortality.Öğe A FUZZY EXPERT SYSTEM DESIGN FOR IRON DEFICIENCY ANEMIA(IEEE, 2013) Yilmaz, Ahmet; Dagli, Mehmet; Allahverdi, NovruzIn this study, an application of fuzzy expert system was introduced. This system was designed to determine the level of iron deficiency anemia and thus, expert physicians were provided with a system to assist them to determine an exact diagnosis prior to their treatment. While realizing the system design, the laboratory records obtained from real patients were examined, the appropriate parameters were specified, the input and output parameters were fuzzified and finally the rule base was built with the expert physician. This study used the centroid defuzzification method together with the Mamdani inference mechanism which is often used in the related literature. With the help of a visual programming language, the level of the disease was displayed in a perceptible way as the result of running the system.Öğe Neutropenia Due to Acute Exposure with Aluminium Phosphide(MODESTUM LTD, 2015) Kutlucan, Ali; Dagli, Mehmet; Kutlucan, Leyla; Basturk, Abdulkadir[Abstract not Available]Öğe The ratio of platelet/lymphocyte, the ratio of neutrophil/lymphocyte and some haemogram parameters related to thrombosis in essential thrombocytosis and polycythaemia vera(SCIENTIFIC PUBLISHERS INDIA, 2017) Kocak, Mehmet Zahid; Dagli, Mehmet; Unlu, AliBackground: It is known that chronic inflammation plays a role in the mechanisms of thrombosis in PV and ET. The NLR and PLR are chronic inflammatory markers. This study aimed to investigate the relation between NLR, PLR and some hemogram parameters with thrombosis in PV and ET Methods: Patient samples were put into in Etilendiamin Tetraasetik Asit (EDTA) tubes and were analyzed on the same day in the CELL-DYN3700SL (United States) device. For evaluating the data statistically, the IBM Statistics15.0 (SPSS) statistic package software was used. Result: A total of 70 patient [26 Prior Thrombosis Event (+) and 44 Prior Thrombosis Event (-)] participated in our study. There was no statistically significant difference in NLR, PLR between patients with and without thrombosis history was determined (p=0,472, p=0,137). Conclusion: This study supports that no relationship between levels of NLR, PLR and thrombosis complications in PV and ET. To our knowledge, our study is the first in literature that evaluates the relation between NLR, PLR and thrombosis in PV and ET.Öğe Serum Prohepcidin and Hepcidin Levels in Patients with Ankylosing Spondylitis: A Prospective Study(DERMAN MEDICAL PUBL, 2016) Dagli, Mehmet; Yilmaz, Sema; Sivrikaya, Abdullah; Ozturk, BahadirAim: Anemia is a common complication in patients with inflammatory diseases such as ankylosing spondylitis. Recent data suggest that hepcidin is a major mediator of anemia with a central role in iron homeostasis and metabolism. The aim of this study was to evaluate the serum levels of hepcidin and its prohormone, prohepcidin, in patients with ankylosing spondylitis in comparison with healthy controls. Material and Method: Forty patients with ankylosing spondylitis (13 with anemia and 27 without anemia). 20 healthy adults were prospectively enrolled. Complete blood count, erythrocyte sedimentation rate, serum levels of hepcidin, prohepcidin, iron, total iron binding capacity, ferritin, transferrin, and C-reactive protein were measured. Results: Serum levels of prohepcidin and hepcidin were significantly higher in patients with ankylosing spondylitis compared to healthy controls (p<0.005). Positive correlation was determined between the serum hepcidin and prohepcidin levels in patients with ankylosing spondylitis (r=0.725, p <0.001). Discussion: To the best of our knowledge, this is the first report of serum levels of prohepcidin and hepcidin in the patients with ankylosing spondylitis. Serum levels of prohepcidin and hepcidin are closely associated with disease activity in patients with ankylosing spondylitis and might play a role in the pathogenesis of anemia of chronic disease associated with ankylosing spondylitis.Öğe Serum Prohepcidin and Hepcidin Levels in Patients withAnkylosing Spondylitis: A Prospective Study(2016) Dagli, Mehmet; Yilmaz, Sema; Sivrikaya, Abdullah; Ozturk, BahadirAmaç: Anemi, Ankilozan spondilit (AS) gibi enflamatuar hastalıklarda sık görülen bir komplikasyondur. Son veriler hepsidinin demir homeostaz ve metabolizmasında rol aldığını ve aneminin önemli bir aracısı olduğunu göstermektedir. Bu çalışmanın amacı, AS'li hastalarda ve sağlıklı kontrollerde serum hepsidin ve hepsidinin prohormonu olan prohepsidin düzeylerinin değerlendirilmesidir. Gereç ve Yöntem: Bu çalışmaya, AS'li kırk hasta (13 anemi olan ve 27 anemi olmayan) ile 20 sağlıklı katılımcı prospektif olarak alındı. Tam kan sayımı, eritrosit sedimantasyon hızı, serum hepsidin, prohepsidin, demir, total demir bağlama kapasitesi, ferritin, transferrin, ve C-reaktif protein düzeyleri ölçüldü. Bulgular: Serum prohepsidin ve hepsidin düzeyleri sağlıklı kontrol ile karşılaştırıldığında, AS'li hastalarda anlamlı olarak yüksek (p 0.005) bulundu. AS'li hastalarda, serum hepsidin ve prohepsidin düzeyleri arasında pozitif korelasyon ( 0.725 r, p 0.001) arasında saptandı. Tartışma: Bizim bilgilerimize göre bu çalışma AS'li hastalarda serum prohepsidin ve hepsidin düzeylerinin araştırıldığı ilk çalışmadır. AS'li hastalarda serum prohepsidin ve hepsidin düzeylerinin hastalığın aktivitesi ile yakından ilişkili olabileceği ve AS ile kronik hastalık anemisinin patogenezinde rol oynayabileceği düşünülmektedir.